Infectious Diseases

Virus plaque of Pseudorabies virus (PRV)
Pseudorabies virus (PRV), a DNA swine alpha herpesvirus, is one of the most widely applied viruses for polysynaptic circuit analysis in the rodent nervous system.

The Department of Microbiology & Immunology is focused on understanding the mechanisms of disease and applying this knowledge to develop novel therapies. Immunologists and researchers in the department collaborate with experts in infectious diseases, resulting in a high number of publications and patents.

 

A closer look at our life-saving research:

 

"Genetic Bases of Host Response to Infections and Chronic Diseases"

The lab of Prof. Fuad Iraqi, Ph.D. actively identifies and characterizes genes involves in the host response to a variety of bacterial and fungal infections, as well as chronic diseases.

 

"Investigating Viral Genetic Diversity"

The research of Dr. Oren Kobiler, M.D., Ph.D.is focused on understanding how viruses, such as herpesvirus, generate and maintain genetic diversity

 

"Human Mold Infections"

Prof. Nir Osherov, Ph.D.investigates the high mortality associated with the mold Aspergillus fumigatus. The goal of his lab is to develop novel modes of treatment including new antifungal compounds, targeted antibodies and nano medicines.

 

"Host-Virus Interactions in Bacterial Systems"

Prof. Udi Qimron, Ph.D. studies basic aspects of bacteriophage growth with emphasis on the recently identified bacterial defense system, the CRISPR. Our ultimate objective is to identify novel strategies that will assist in overcoming drug-resistant pathogens.

 

"Viral Host Interactions of Positive Strand RNA Viruses"

Dr. Ella Sklan, Ph.D. uses the Hepatitis C virus and Dengue to indentify and characterize the interactions of viruses with their host cells.

 

"Human Antibody Responses in Health and Disease"

Dr. Natalia T. Freund, Ph.D. uses molecular immunology and genetics, combined with innovative single cell methods, to isolate high-affinity disease-specific antibodies from memory B cells of infected patients.

 

"Bacterial Protein Secretion Systems and Toxins"

Dr. Dor Salomon, Ph.D.  and his lab are identifying novel virulent and antibacterial toxins and determining their mechanism of action and their targets. 

 

 

"Investigating the Pathogenics of Candidiasis, Epidemiology of Dermatophytosis and Experimental Antifunal Drugs"

Prof. Esther Segal, Ph.D. focuses on studying phenotypic and genotypic characteristics of clinical Candida albicans strains from systemic and mucosal candidiasis in vitro and in vivo in experimental animal models, mice, and Galleria mellonela. 

 
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