Prof. Esther Segal

Emeritus in Clinical Microbiology and Immunology
School of Continuing Medical Education
מיקרוביולוגיה ואימונולוגיה קלינית אמריטוס
Prof. Esther Segal
Phone: 03-6409870
Fax: 03-6409160
Office: Sackler School of Medicine, 813


Academic Appointments 

1993-present  Full Professor, Department of Microbiology & Immunology, Sackler School of Medicine, Tel Aviv University, Israel. 
1997-1999; 2003-2005 Head, Department of Human Microbiology, Sackler School of Medicine,Tel Aviv University, Israel 




1958 M.Sc., Microbiology Tel Aviv University
1969 Ph.D. in Yeast Genetics University of Bern, Switzerland
1975-76 Specialization in Medical Mycology CDC, Atlanta, Georgia, U.S.A. 
1978 Histopathology Armed Forces Institute of Pathology, Washington D.C., U.S.A.
1985 Molecular Biology University of Illinois, Urbana, Illinois, U.S.A, 



The research in my laboratory focuses on three main areas related to fungal infections in humans and animals: 

    1. Fungal virulence factors and pathogenesis of fungal infections. 
    2. Therapy of fungal infections. 
    3. Prevention of infection by intervention with the pathogenic process 


Selected Publications

Sandovsky-Losica, H., Shwartzman, R., Lahat, Y. and Segal, E.Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B. Journal of Antimicrobial Chemotherapy, 2008.


Schindler, B. and Segal, E. Candida albicans metabolite affects the cytoskeleton and phagocytic activity of murine macrophages. Medical Mycology, 46: 251-258, 2008.


Kyselgof, G., Sandovsky-Losica, H., Berdicevsky, I. and Segal E.Caspofungin affects adhesion of Candida to a human cell line. Journal of Medical Mycology, 17: 1-71, 2007.


Zilberman, M., Navon, A., Sandovsky-Losica, H and Segal, E.Biomedical coatings based on chitin soluble extract for inhibition of fungal adhesion to polymeric surfaces. Journal of Biomedical Materials. 81:392-398, 2007.


Sandovsky-Losica, H., Chauhan, N., Calderone, R. and Segal, E.Gene transcription studies of Candida albicans following infection of HEp2 epithelial cells. Medical Mycology, 44:329-334, 2006.


Sandovsky-Losica, H. and Segal, E. Infection of HEp2 epithelial cells with Candida albicans: adherence and post-adherence events. FEMS Immunology and Medical Microbiology, 46: 470-475, 2006.


Sionov, E., Mendlovic, S. and Segal, E. Efficacy of amphotericin B or amphotericin B intralipid in combination with caspofungin against experimental aspergillosis. Journal of Infection, 53:131-139, 2006.


Segal, E. and Elad, D. Fungal vaccines and immunotherapy. Journal of Medical Mycology, 16: 134-151, 2006.


Segal, E. and Elad, D. Candida and Candida infection. In: Topley and Wilson’s Microbiology and Microbial Infections.Edward Arnold Publishers. 10th Ed.Vol. Medical Mycology, pp.579-623, 2005. 


Sionov, E., Mendlovic, S. and Segal, E. Experimental systemic murine aspergillosis: treatment with polyene and caspofungin combination and G-CSF. Jounal of Antimicrobial Chemotherapy, 594-597, 2005.


Shadkhan, Y., Keisari, Y. and Segal, E. Cytokines in mice treated with Amphotericin B-intralipid. Medical Mycology, 42: 123-128, 2004. 


Sionov, E. and Segal, E. Polyene and cytokine treatment of experimental aspergillosis, FEMS Immunology and Medical Microbiology, 39: 221-227, 2003. 


Segal, E. and C. Baum. Pathogenic Yeasts and Yeast Infections. CRC Press, 1994

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