Prof. Nir Osherov

מיקרוביולוגיה ואימ.קליני סגל אקדמי בכיר
Prof. Nir Osherov
Phone: 03-6409599
Another phone: 03-6409946
Fax: 03-6409160
Office: Sackler School of Medicine

Positions

Associate Professor, Sackler Faculty of Medicine

Chair, Department of Human Microbiology and Immunology

Chair, M.Sc. Committee, Sackler School of Medicine

Director, Ella Kodesz Institute of Host Defense against Infectious Diseases

 

Biography

Education

1984-1988 B.Sc, Biology Hebrew  University
1988-1994 Ph.D., Biochemistry Hebrew University
1994-1996 Post-Doctoral studies. Dictyostelium development University of California- San Diego
1996-2001 Post-doctoral studies. Aspergillus biology Baylor College of Medicine and MD Anderson Cancer Center

 

Research

Human Mold Infections

Aspergillus fumigatus is the most common mold pathogen of human beings, causing invasive diseases in immunocompromised (cancer after chemotherapy, bone marrow transplant etc) patients. Poor diagnostic tools and the ineffectiveness of antifungal drugs against established Aspergillus infections combine to result in high mortality following A. fumigatus infection. Left untreated, mortality rates from invasive pulmonary aspergillosis (IPA) exceed 90% and even following aggressive antifungal treatment fatality rates of 50-70% are common.

 

The goals of my lab are:

  • To understand what enables this mold to be such an effective and dangerous pathogen of immunocompromised patients
  • To develop novel modes of treatment including new antifungal compounds, targeted antibodies and nano medicines.

 

Publications & Grants

Publications

Vaknin Y, Shadkchan Y, Levdansky E, Morozov M, Romano J, Osherov N. The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence. Fungal Genet Biol. 2014;63:55-64.

 

Osherov N. Interaction of the pathogenic mold Aspergillus fumigatus with lung epithelial cells. Front Microbiol. 2012, 26:346.

 

Hagag S, Kubitschek-Barreira P, Neves GW, Amar D, Nierman W, Shalit I, Shamir R, Lopes-Bezerra L, Osherov N. Transcriptional and proteomic analysis of the Aspergillus fumigatus ΔprtT protease-deficient mutant. PLoS One. 2012, 7:e33604.

 

Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y. Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents. J Med Chem. 2012, 9:1296-302.

 

Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y. Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrinand amphotericin B. Antimicrob Agents Chemother. 2012, 56:1-9.

 

Sharon H, Amar D, Levdansky E, Mircus G, Shadkchan Y, Shamir R, Osherov N. PrtT-regulated proteins secreted by Aspergillus fumigatus activate MAPK signaling in exposed A549 lung cells leading to necrotic cell death. PLoS One. 2011, 6:e17509.

 

Levdansky E, Kashi O, Sharon H, Shadkchan Y, Osherov N. The Aspergillus fumigatus cspA gene encoding a repeat-rich cell wall protein is important fornormal conidial cell wall architecture and interaction with host cells. Eukaryot Cell. 2010, 1403-15

 

Appel E, Vallon-Eberhard A, Rabinkov A, Brenner O, Shin I, Sasson K, Shadkchan Y, Osherov N, Jung S, Mirelman D. Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin. Antimicrob Agents Chemother. 2010, 54:898-906.

 

 

Reviews
Osherov N. The top three areas of basic research on Aspergillus fumigatus in 2011. Ann N Y Acad Sci.  2012, 1273:74-7.

 

Tavanti A, Naglik JR, Osherov N. Host-Fungal Interactions: Pathogenicity versus Immunity. Int J Microbiol. 2012, 562480.

 

 

Grants

2012- 2016                  Binational Science Foundation

2014-2016                   Israel-Italy Cooperation Grant

2014-2017                   Infect-ERA Net Joint European Grant

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
UI/UX Basch_Interactive