Prof. Ella Sklan

Clinical Microbiology and Immunology
Medicine Dean & Assoc. Deans

מיקרוביולוגיה ואימונולוגיה קלינית סגל אקדמי בכיר

Email: sklan@tauex.tau.ac.il

Phone: 03-6408197

Another phone: 03-6409486

Fax: 03-6409160

My CRIS profile

Lab website

Google Scholar

Office: School of Medicine, 807

CV

2004-2008 Post-Doctoral Fellow, division of gastroenterology and hepatology, Stanford school of medicine, Stanford, CA

1999-2004 Ph.D., Department of Biological Chemistry, The Life Sciences Institute, The Hebrew University of Jerusalem.

1998-1999 Masters in Business Administration (MBA), School of Management, Ben-Gurion University, Beer-Sheva.

1996-1997 Masters of Medical Sciences (M. Med. Sci) Cum Laude. Health Sciences, Ben-Gurion University, Beer-Sheva.

1993-1996 Bachelor of Science (B. Sc) in Biology, Ben-Gurion University, Beer-Sheva.

Academic Positions

Associate professor, Department of Clinical Immunology and Microbiology, Sackler Faculty of Medicine, Tel-Aviv University.

Research

Research Interests

Our long-term goal is the identification and characterization of the interactions of viruses with their host cells. Our current model systems include Sandfly viruses, Zika and Dengue viruses, and Hepatitis viruses.

Current projects in the lab include:

CRISPR screens for the identification and characterization of new interactions between viruses and host cells.
Using live cell imaging techniques to study viral-host interactions.
Identification of the mechanism of action of antiviral interferon-stimulated genes.

Publications

Publications (last 3 years)

Circulating lncRNAs as biomarkers for severe dengue using a machine learning approach.Katz R, Nam NM, de Lima Campos T, Indenbaum V, Terenteva S, Hang DTT, Hoi LT, Danielli A, Lustig Y, Schwartz E, Tong HV, Sklan EH. J Infect. 2025 Apr;90(4):106471. doi: 10.1016/j.jinf.2025.106471.
Numb-associated kinases regulate sandfly-borne Toscana virus entry. Moalem Y, Katz R, Subramaniam AG, Malis Y, Yaffe Y, Borenstein-Auerbach N, Tadmor K, Raved R, Maoz BM, Yoo JS, Lustig Y, Luxenburg C, Perlson E, Einav S, Sklan EH. Emerg Microbes Infect. 2024 Dec;13(1):2382237. doi: 10.1080/22221751.2024.2382237.
Rab1b facilitates lipid droplet growth by ER-to-lipid droplet targeting of DGAT2. Malis Y, Armoza-Eilat S, Nevo-Yassaf I, Dukhovny A, Sklan EH, Hirschberg K. Sci Adv. 2024 May 31;10(22):eade7753. doi: 10.1126/sciadv.ade7753.
Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity. Diep NT, Giang NT, Diu NTT, Nam NM, Khanh LV, Quang HV, Hang NT, Mao CV, Son HV, Hieu NL, Linh PT, Sklan EH, Toan NL, Tong HV. Sci Rep. 2023 Oct 13;13(1):17377. doi: 10.1038/s41598-023-44512-w.
The Role of NS1 Protein in the Diagnosis of Flavivirus Infections. Fisher R, Lustig Y, Sklan EH, Schwartz E. Viruses. 2023 Feb 19;15(2):572. doi: 10.3390/v15020572.
Elevated Serum Amyloid A Levels Contribute to Increased Platelet Adhesion in COVID-19 Patients. Siman-Tov R, Shalabi R, Shlomai A, Goldberg E, Essa W, Shusterman E, Ablin JN, Caspi M, Rosin-Arbesfeld R, Sklan EH. Int J Mol Sci. 2022 Nov 17;23(22):14243. doi: 10.3390/ijms232214243.
Sandfly Fever Viruses Attenuate the Type I Interferon Response by Targeting the Phosphorylation of JAK-STAT Components. Moalem Y, Malis Y, Voloshin K, Dukhovny A, Hirschberg K, Sklan EH. Front Immunol. 2022 Jun 1;13:865797. doi: 10.3389/fimmu.2022.865797.
Methods for fighting emerging pathogens. Alcantara LCJ, Amenga-Etego L, Andersson R, Bhaumik M, Choi YK, Decaluwe H, Geoghegan J, Haagmans BL, López S, Mukhtar MM, Nelwan E, Rahal EA, Sato K, Sklan EH, Fang YSC. Nat Methods. 2022 Apr;19(4):395-397. doi: 10.1038/s41592-022-01441-2.
A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells. Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH. FASEB J. 2022 Mar;36(3):e22191. doi: 10.1096/fj.202101507RR.