Prof. Fuad Iraqi

מיקרוביולוגיה ואימ.קליני סגל אקדמי בכיר
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Prof. Fuad Iraqi
Phone: 03-6409321
Fax: 03-6409160
Office: Sackler School of Medicine, 746

Positions

Full Professor, Sackler Faculty of Medicine

Chair, Department of Human Microbiology and Immunology

 

Research

Genetic Bases of Host Response to Infections and Chronic Diseases

 

The research in my laboratory is focused on understanding the genetic bases of host response to infections and chronic diseases, which are important for human health. My team uses mouse model for speeding up the process of identifying such genes, which may involved of making some people resistant to a diseases while others are not. After finding the genes in mouse, it will be possible to identify the homologous genes in human. The product of our research can be used in developing new prevention and treatment tools for these diseases.

 

The main ongoing research projects at his lab are:

  • Identifying and characterizing genes involved in host response to bacterial infection by Klebsiella Peumonia.
  • Identifying and characterizing genes involved in host response to fungal infection by Aspergillus Fumigatus (Aspergillosis)
  • Identifying and characterizing genes involved in host response to bacterial that causes dental infection (periodontitis)
  • Identifying and characterizing genes involved in development of type-2 diabetes (T2D) in humans as a result of obesity and high fat-diet.
  • Identifying and characterizing genes involved in host immune response to infectious and chronic diseases.
  • Identifying and characterizing genes involved in development of colon cancer.

 

Publications

 

  1. Rigbi M, Eldor A, Galun R, Ginsburg, I, Iraqi F, Orevi M, Teitelbaum A (1985) Leech saliva and salivary glands extraction: A battery of factors to counteract haemostasis and leukocyte activity, Israel. J. Clin. Biochem. Lab. Sci. 4:63. (Biochemistry and Molecular Biology 95/261, IF 3.099)
  2. Rigbi M, Levy H, Iraqi F, Teitelbaum M, Orevi M, Aljoutsijarvi A and Galum R (1987) The saliva of the medicinal leech Hirudo Medicinalis I. Biochemistry characterization of the high molecular weight fraction. Comp. Biochem. Physiolol. 87:567-573. (Biochemistry and Molecular Biology 221/261, IF 0.934)
  3. Rigbi M, Levy H, Eldor R, Iraqi F, Teitelbaum M, Orevi M, Horovitz A and Galun R (1987) The Saliva of the Medicinal Leech Hirudo Medicinalis II. Inhibition of platlet aggregation and Leukocyte activity and examination of reputted anesthetic. Comp. Biochem. Physiolol. 88:95-98. (Zoology 25/114, IF 1.456)
  4. Kashi Y, Iraqi F, Tikochinski Y, Ruzinzki B, Nave A, Beckmann J, Freidman A, Soller M and Gruenbaum Y (1990). (TG)n uncovers a sex- specific hybridization pattern in cattle. Genomics 7:31-36. (Genetics and Heredity 26/120, IF 4.289)
  5. Iraqi F, Soller M and Beckmann JS (1990). Endogenous viruses in commercial layer lines. Revista Brasileiro de Reproduçao Animal 2:75-79. (Veterinary Science 70/129, IF 1.233)
  6. Kashi Y, Tikochenski Genslav E, Iraqi F, Nave A, Beckmann JS, Gruanbaum Y and Soller M (1990). Large restriction fragments containing Poly-TG are highly polymorphic in variety of vertebrates. Nucl. Acids Res. 5:1129-1132. (Biochemistry and Molecular Biology 24/261, IF 7.552)
  7. Iraqi F, Soller M and Beckmann JS (1991) Distribution of endogenous virus in some commercial layer populations. Poultry Science 70:665-679. (Veterinary Science 70/129, IF 1.233)
  8. Iraqi F, Khative H, Darvasi A, Frumkin M, Soller M, Faisond A and Gruenbaum Y (1992). Chox-Cad locus may influence quantitative traits in chickens. J. Exper. Zool. 263:303-308. (Evolutionary Biology 16/33, IF 2.387)
  9. Iraqi F, Gong Z, Crime L and Hew CL (1993) The isolation and characterisation of Somatolactin genes from two cold marine Teleosts. Molec. Marine Biol. Biotech. 2:96-103. (Biotechnology and Applied Microbiology 73/135, IF 1.543)
  10. Iraqi F, Darvasi A, Zeitlin G, Beckmann JS  and Soller M (1994). Non-linear effect of chicken endogenous viruses on body weight may be responsible for maintaining these elements in stable genetic polymorphism. Poultry Science 73:1625-1632. (Veterinary Science 70/129, IF 1.233)
  11. Iraqi F and Smith EJ (1994) Determination of avian endogenous provirus-cellular junction sequences using inverse polymerase chain reaction. Animal Biotech 5:69-80. (Biotechnology & Applied Microbiology 102/135, IF 0.906)
  12. Iraqi F and Smith EJ (1994) Determination of the zygosity of ev21-k in late feathering male white leghorns using the polymerase chain reaction. Poultry Science 70:939-946. (Veterinary Science 70/129, IF 1.233)
  13. Iraqi F and Smith EJ (1995) Orginization of the sex-linked late feathering haplotype in chickens. Animal Genet. 26:141-146. (Genetics and Heredity 65/120, IF 2.437)
  14. Iraqi F, Robinson D and Smith EJ (1995) A restriction enzyme map of the sex-linked late feathering locus of chicken. Poultry Science 74:1515-1519. (Veterinary Science 70/129, IF 1.233)
  15. Nave A, Iraqi F and Soller M (1997) A PCR-based test for the presence of endogenous virus gene evA in chicken. Poultry Science 28:46-48. (Veterinary Science 70/129, IF 1.233)
  16. Teale A, Iraqi F,  Darvasi A, Hanotte O, Gathuo H, Sileghem M, Womack J, Soller M and Kemp S (1996) Genetics of resistance to trypanosomiaisis in mice and livestock. Animal Genet. 27:5-8. (Genetics and Heredity 65/120, IF 2.437)
  17. Kemp SJ, Iraqi F, Darvasi A, Soller M and Teale AJ (1997) Localisation of genes controlling resistance to trypanosomiasis in mice. Nature Genet. 16:194-197. (Genetics and Heredity 1/120, IF 25.797)
  18. Iraqi F and Teale AJ (1997) Cloning and sequencing of TNFA genes of three inbred mouse strains. Immunogenet. 45: 459-461. (Genetics and Heredity 55/120, IF 2.976)
  19. Iraqi F and Teale AJ (1998) Polymorphisms in TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice. Immunogenet. 48:302-304. (IF 2.976; Genetics and Heredity 55/120)
  20. Iraqi F and Teale AJ (1998) Polymorphisms in the TNFa gene of different inbred mouse strains. Immunogenet. 49: 242-245. (Genetics and Heredity 55/120, IF 2.976)
  21. Iraqi F, Kemp S and Teale AJ (1998) Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines. ISAG, Auckland, New Zealand. August 9-15, 1998. Animal Genet. 29(suppl):45. (Genetics and Heredity 65/120, IF 2.437)
  22. Koundande D, Iraqi F, Van Arendonk J and Teale AJ (1998) Marker assisted introgression of multiple unlinked QTL: Experimental design and consequences. ISAG, Auckland, New Zealand. August 9-15, 1998. Animal Genet. 2:72. (Genetics and Heredity 65/120, IF 2.437)
  23. Nilsson P, Kanga S, Rottengatter K, Suedbeck U, Iraqi F, Mwakaya J, Mwangi D, Womack J, Goldammer T, Schwerin M, Bradley D, Sugimoto K, Gelhaus A, Teale AJ, Kemp S, Hanotte O (1999) Radiation hybrid maps of candidate trypanotolerance chromosomal regions in cattle. Arch. Animal Breeding 42:123-125. (Animal Sciences 70/130, IF 0.634)
  24. Teale AJ, Agaba M, Clapcott S, Gelhaus A, Haley C, Hanotte O, Horstmann R, Iraqi F, Kemp S, Nilsson P, Schwerin M, Sekikawa K, Soller M, Sugimoto K, Womack J (1999) Resistance to trypanosomosis: of markers, genes and mechanism. Arch. Animal Breeding 42:36-41. (Animal Sciences 70/130, IF 0.634)
  25. Iraqi F, Marteen S and Teale AJ (1999) TNF-a expression in trypanosomiais resistant and susceptible mouse strains during infection with Trypanosoma congolense. Arch. Animal Breeding 42:119-122. (Animal Sciences 70/130, IF 0.634)
  26. Koundande D, Iraqi F, Thomson P, Teale AJ, Van Arendonk J (2000) Strategies to optimize marker-assisted introgression of multiple unlinked QTL. Mamm. Genome 11:145-150. (Genetics & Heredity 58/120, IF 2.747)
  27. Behnke J, Lowe A, Menge D, Iraqi F and Wakelin D (2000) Mapping the genes for resistance to Gastrointestinal Nematodes. Acta Parasitologica 45:1-13. (Microbiology 70/86, IF 0.987)
  28. Iraqi F, Clapcot S, Kuman P, Heley C, Kemp S and Teale AJ (2000) Fine mapping of trypanosomiasis resistance QTLs in mice using advanced intercross lines. Mamm. Genome 11:645-648. (Genetics & Heredity 58/120, IF 2.747)
  29. Iraqi F (2000) Fine mapping of quantitative trait loci using advanced intercross lines of mice and positional cloning of the corresponding genes. Experimental Lung Res. 26, 641-649. (Oncology 58/123, IF 2.503)
  30. Wambugu J, Knaguha E, Hanotte O, Davis S, Taylor J, Skaw L, Brunner R, Schwerin M, Teale A and Iraqi F (2001) Identification of a polymorphic dinucleotide repeat on a bovine TNF-a-containing BAC clone. Animal Genet. 32:105-106. (Genetics and Heredity 65/120, IF 2.437)
  31. Gershenfeld H, Lou Y, Anyango M, Mohibullah N, Osoti A, King R, Iraqi F (2001) The genetic architecture of exploratory and fear like behavior in mice: a comparison of two complementary strategies for fine mapping QTLs. Am. J. Human Genet.  69:545. (Genetics and Heredity 22/261, IF 7.762)
  32. Iraqi F, Sekikawa K, Rowlands J and Teale A (2001) Susceptibility of TNF-a genetically deficient mice to Trypanosoma congolense infection. Parasite Immunol. 23, 445-451. (Parasitology 8/25, IF 2.523)
  33. Falcon CA, Omamo SW, d’Ieteren G and Iraqi F (2002) An ex ante economic and policy analysis of rearch on genetic resistance to livestock disease: Trypanosomosis in Africa. Agricul. Economics 25:153-163. (Agriculture 50/230, IF 0.684)
  34. Kitani, H, Black JS, Nakamura Y, Naessens J, Gibson J, Murphy N, Yokomizo Y and Iraqi F (2002) Recombinant tumor necrosis factor a does not inhibit the growth of African trypanosomes in axenic cultures. Infection & Immunity 70:2210-2214. (Infectious Diseases 8/43, IF 3.933)
  35. Behnke J, Iraqi FA, Menge D, Baker L, Gibson J and Wakelin D (2003) Chasing the genes that control resistance to GI nematodes. J. Helminthology 77:99-109. (Parasitology 21/22, IF 0.581)
  36. Iraqi F, Behnke J, Menge D, Lowe A, Teale AJ, Gibson PJ, Baker L and Wakelin D (2003) Chromosomal regions controlling resistance to gastro-intestinal nematode. Mamm. Genome 14:184-191. (Genetics & Heredity 58/120, IF 2.747)
  37. Nakamura Y, Naessens J, Takata M, Taniguchi T, Sekikawa K, Gibson J and Iraqi F (2003) Susceptibility of heat shock protein 70.1-deficient C57BL/6J, wild-type C57BL/6J and A/J mice to Trypanosoma congolense infection. Parasitology Res. 90:171-174. (Immunology 90/115, IF 1.445)
  38. Menge D, Behnke MJ, Lowe A, Gibson PJ, Iraqi F, Baker LR and Wakelin D (2003) Mapping of chromosomal regions influencing immunological responses to Gastro-intestinal Nematode infections in Mice. Parasite Immunol. 25:341-349. (Parasitology 8/25, IF 2.523)
  39. Wang M, Lemon WJ, Liu G, Wang Y, Iraqi FA, Malkinson AM and You M (2003) Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Cancer Res. J. 63:3317-3324. (Oncology 15/123, IF 5.715)
  40. Bernert H, Sekikawa K, Radcliffe R, Iraqi F, You M and Malkinson AM (2003) Tnfa and Il-10 deficiencies have contrasting effecets on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsuficiency. Molec. Carcinogenesis 38:117-123. (Oncology 16/123, IF 5.417)
  41. Abiola, O., Angel, J., Avner, A, et al., (2003) The nature and identification of quantitative trait loci: a community’s view. Nature Reviews Genetics 4:911-916. (Genetics and Heredity 2/120, IF 19.211)
  42. Hernandez-Valladares M, Naessens J, Gibson JP, Musoke AJ, Rihet P, ole-MoiYoi OK and Iraqi FA (2004) Confirmation and dissection of QTL controlling resistance to malaria in mice. Mamm. Genome 15:390-398. (Genetics & Heredity 58/120, IF 2.747)
  43. Hernandez-Valladares M, Rihet P, ole-MoiYoi OK and Iraqi FA (2004) Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative approach of human chromosome 5q31-q33. Immunogenet. 56:115-117. (Genetics and Heredity 55/120, IF 2.976)
  44. Kitani H, Yagi Y, Naessens J, Sekikawa K and Iraqi F (2004) The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-alpha gene. Acta Tropica. 92:35-42. (Parasitology 6/22, IF 1.8)
  45. Naessens J, Kitani H, Momotani E, Sekikawa K, Nthale JM, Iraqi FA (2004) Susceptibility of TNF-a-deficient mice to Trypanosoma congolense is not due to a defective antibody response. Acta Tropica. 92:193-204. (Parasitology 6/22, IF 1.8)                    
  46. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD,….. Iraqi FA et al., (2004) The Collaborative Cross: a community resource for genetic analysis of complex traits. Nature Genet. 36:1199-1137. (Genetics and Heredity 1/120, IF 25.797)
  47. Hernandez-Valladares M, Naessens J, Nagda S, Musoke AJ, Rihet P, ole-MoiYoi OK and Iraqi FA (2004) Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi. Exper. Parasitol. 108:134-141. (Parasitology 11/22, IF 1.751)
  48. Naessens J, Kitani H, Nakamura Y, Yagi Y, Sekikawa K and Iraqi FA (2005) TNF-a mediates the development of anaemia in murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanodoma congolense infection. Clin. Exper. Immunol. 139:405-410. (Immunology 46/115, IF 2.805)
  49. Koudandé OD, Arendonk JAM, and Iraqi FA (2005). Trypanotolerance QTL introgression in mice: experimental results. Mamm. Genome 16:112-119. (Genetics & Heredity 58/120, IF 2.747)
  50. Flori L, Delahaye NF, Iraqi FA, Hernandez-Valladares M, Fumoux F and Rihet P (2005) TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. Genes Immmunity 6:472-480. (Genetics and Heredity 34/120, IF 3.779)
  51. Zhang S, Lou Y, Amstein T, Anyango M, Mohibullah N, Osoti A, King R, Iraqi FA and Gershenfeld H (2005) Fine mapping of a major locus on chromosome for exploratory and fear-like behavior in mice. Mamm. Genome 16:306-18. (Genetics & Heredity 58/120, IF 2.747)
  52. Foote, S., Iraqi, F.A. and Kemp, S. (2005) Controlling Malaria and African Trypanosomiasis: the role of the Mouse. Briefings Functional Genomics and Proteomics 4:214-224. (Biochemistry and Molecular Biology 70/261, IF 2.247)
  53. Hernandez-Valladares M, Naessens J, Iraqi FA. (2005) Genetic resistance to malaria in mouse models. Trends in Parasitology 21:352-355. (Trends in Parasitology 1/22, IF 4.526)
  54. Delahaye NF, Coltel N, Puthier D, Flori L, Houlgatte R., Iraqi FA., Nguyen C, Grau GE and Rihet P. (2006) Gene expression profiling discriminates cerebral malaria-susceptible mice and cerebral malaria-resistant mice. J. Infectious Dis. 193:312-321. (Infectious Diseases 6/43, IF 4.953)
  55.  Behnke JM, Mugambi JM, Cliffford S, Iraqi FA, Baker LR, Gibson JP and Wakelin D. (2006) Genetic variation in the resistance to repeated infections with Heligmosomoides polygyrus bakeri, of inbred mouse strains selected for the Mouse Genome Project. Parasite Immunol. 28:85-94. (Parasitology 8/25, IF 2.523)
  56. Behnke JM(, Iraqi FA, Mugambi JM, Clifford S, Nagda S, Wakelin D, Baker LR and Gibson JP. (2006) High resolution mapping of chromosomal regions controlling resistance to gastro-intestinal nematode infections in an advanced intercross line of mice. Mamm. Genome 17:1-14. (Genetics & Heredity 58/120, IF 2.747)
  57. Sonstegard T, Iraqi FA, Mugambi J, Van Tassell C, Garcia F, Hanotte O, Nagda S, Gibson J and Baker L (2006) Identification of quantitative trait loci affecting parasite indicator traits in a double backcross population of sheep. J. Animal Sci. 84:379. (Veterinary Sciences 7/129, IF 2.123)
  58. Hernandez-Valladares M, Naessens, J, Musoke, AJ, Sekikawa, K, Rihet, P, ole-MoiYoi, OK and Iraqi, FA. (2006) Pathology of TNF-deficient mice infected with Plasmodium chabaudi adami 408XZ. Experimental Parasitol. 114:271-278. (Parasitology 11/22, IF 1.751)
  59. Rukonga GM, Muregi FW, Tolo FM, Omar SA, Mwitari P, Muthaura CN, Omlin F, Lwande W, Hassanali A, Githure J, Iraqi FA, Mungari GM, Kraus W and Kofi-Tsekpo WM (2007) The antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera. Fitoterapia 78:455-459. (Pharmacology & Pharmacy 160/192, IF 1.106)
  60. Nganga J, Imbuga M and Iraqi FA (2007) Comparative genome analysis of trypanotolerance QTL. African J. Biotech. 6:967-970. (Biotechnology & Applied Microbiology 112/135, IF 1.212)
  61. Yoshihara K, Agaba M, Iraqi FA and Naessens J (2007) Cytokine mRNA profiles in bovine macrophages stimulated with Trypanosoma congolense. J. Veterinary Med. 69:421-423. (Veterinary Sciences 11/129, IF 1.649)
  62. Delahaye NF, Coltel N, Puthier D, Barbier M, Iraqi FA, Grau GE, Nguyen C and Rihet P (2007) Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible and resistant mice. Biomed Central Genomics 8:452-459. (Biotechnology & Applied Microbiology 17/135, IF 4.189)
  63. Kamau JM, Mwai OM, Kinyanjui PW and Iraqi FA (2007) Fine mapping of trypanosomosis resistance loci in murine by haplotype approach. Kenyan Veterinarian 31:64 –67. (Entomology 29/73, IF 0.95)
  64. Hernandez-Valladares, M., Naessens, J., Iraqi FA (2007) Gene knockout mice in malaria research: useful or doubtful? Trends in Parasitology 23:522-526. (Parasitology 1/22, IF 4.909: Times Cited 1)
  65. Kamau JM, Mwai OM, Kinyanjui PW and Iraqi FA (2007) Trypanotolerance effect as a result of genomic imprinting in F2 murine population. Kenyan Veterinarian 31:68–71. (Entomology 29/73, IF 0.95)
  66. Koudande DO, Thomson PC, Bovenhuis H, Iraqi FA, Gibson J and van Arendonk J (2008) Biphasic survival analysis of Trypanotolerance QTL in mice. Heredity 6:407-414. (Genetics & Heredity 38/138, IF 4.065)
  67. Iraqi FA, Churchill G and Mott R (2008) The Collaborative Cross, developing a resource for mammalian systems genetics: A status report of the Wellcome Trust Cohort. Mamm. Genome 19:379-381. (Genetics & Heredity 78/138, IF 2.35).
  68. Nganga J, Imbuga M and Iraqi FA (2009) Comparative genome analysis of trypanotolerance QTL. Veterinary Immunol. Immunopathol. 128:216 (Veterinary 12/129, IF 1.957)
  69. Nganga J and Iraqi FA (2009) Expression variation of TLR as candidate genes underlying trypanotolerance QTL in mice Veterinary Immunol. Immunopathol 128:216-217 (Veterinary 12/129, IF 1.957, IF 1.957)
  70. Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi FA, Kemp SJ, Rathkolb B, Wolf E, Hrabé de Angelis M, Roshandel D and Naessens J (2009) Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLOS One 4:e5170. (Biology 2/115, IF 4.41)
  71. Kitani H, Naessens J, Kubo M, Nakamura Y, Iraqi FA, Gibson J and Yamakawa  M (2009) Synthetic nonamer peptides derived from insect defensin mediate the killing of African trypanosomes in axenic culture. J. Parasitol. Res. 105:217-25. (Parasitology 13/23, IF 1.522)
  72. Rathkolb B, Brass A, Paul Dark, Gailus-Durner V, Gibson J, Fuchs H, Martin Hrabé de Angelis M, Iraqi FA, Kemp SJ, Naessens J, Pope M, Wolf E, Noyes HA and Agaba M (2009) Clinical chemistry of mice congenic for QTL for response to Trypanosoma congolense infection suggests that survival is not regulated by resistance to the parasite. Infection & Immunity 77:3948-3957. (Infectious Diseases 8/43, IF 3.993)
  73. Behnke JM, Menge D, Nagda S, Noyes HA, Iraqi FA, Kemp SJ, Mugambi JM, Baker LR, Wakelin D and Gibson JP (2010) Quantitative trait loci for resistance to worm infections and associated immunological and pathological traits in mice: Comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 intercross lines of mice. Parasitol. 137:311-32. (Parasitology 8/23, IF 2.081)
  74. Nganga JK, Soller M, Iraqi FA. (2010) Towards high resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 by using F12 advanced intercross lines with major locus Tir1 effect depleted. BMC-Genomics 11(394):1-10. (Biotechnology & Applied microbiology 29/165, IF 4.041: Times Cited 2).
  75. Goodhead I, Amwayi P, Brass A, Hall N, Archibald A,
  76. Hughes M, Iraqi FA, Kemp S, Noyes H (2010) A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Neglected Tropical Diseases. 4(11) E880: 1-13. (Tropical Medicine 1/22, IF 4.489: Times Cited 11).
  77. Schughart K, Arends D, Andreux P, Balling R, Beyer A, Bezerianos A, Brockmann GA, Crusio WE, Campbell-Tofte J, Denny P, Falcon-Perez JM, Forejt J, Franken P, Hovatta I, Iraqi FACO, Jansen RC, Kaczmarek L, Kas MJ, Kashofer K, Kolisis F, Kõks S, Lammert F, Möller S, Montagutelli X, Morahan G, Mott R, Pfoertner S, Prins P, Przewlocki R, Ranki A, Santos J, Rihet P, Schalkwyk L, Smit AB, Swert M,  Zatloukal EZ. (2010) SYSGENET – a meeting report from a new European network for systems genetics. Mamm. Genome 21:331-336 (Biotechnology & Applied Microbiology 50/165, IF 2.883: Times Cited )
  78. Kovacs A, Ben-Jacob N, Tayem H, Halperin E, Iraqi FA, Gophna U (2011) Genotype is a stronger determinant than sex of the mammalian gut microbiota. Microbial Ecology 61(2):423-8. (Marine & Freshwater Biology 9/103, IF 3.118: Times Cited 54).
  79. Aylor DL,  William V, Wendy FMW, Buus RJ, Ricardo A. Verdugo RA, Ralph S. Baric RS, Ferris M, Frelinger FA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JP, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A,Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, l Pomp D, Threadgill D, de Villena FPM, Churchill GA (2011) Genetic Analysis of Complex Traits in the Emerging Collaborative Cross. Genome Research 21(8): 1213-1222. (Biotechnology & Applied Microbiology 10/298, IF 11.779: Cited 135). Q1
  80. Durrant C, Tayem H, Yalcin B, Cleak J, Goodstadt L, Pardo-Manuel de Villena F, Mott R, Iraqi FA (2011). Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection. Genome Research 21(8): 1239-1248. (Biotechnology & Applied Microbiology 10/298, IF 11.779: Times Cited 40). Q1
  81. *These authors contributed equally to this work.
  82. Silva MVB, Sonstegard TS, Hanotte O, Mugambi J, Garcia JF, Nagda S, Gibson J,  Iraqi FA, McClintock S, Kemp S, Boettcher P, Malek M, Van Tassell CP, Baker LR (2012) Identification of quantitative trait loci affecting resistance to gastro-intestinal parasites in a double backcross population of Red Maasai and Dorper sheep. Animal Genetics 43: 63-71. (Agriculture, Dairy & Animal Science 7/58, IF 1.779: Times Cited 18). Q1
  83. Iraqi FA, Mahajne M, Salaymeh A, Sandovsky H, Tayem H, Vered K, Balmer L, Hall M, Manship G, Morahan G, Pettit K, Scholten J, Tweedie K, Weerasekera L, Cleak J, Durrant C, Goodstadt L, Mott R, Yalcin B, Aylor DL, Baric R, Bell TA, Bendt KM, Brooks JD, Buus RJ, Crowley JJ, Calaway JD, Calaway ME, Cholka A, Darr DB, Didion JP, Dorman A, Everett E, Ferris MT, Mathes WF, Fu CP, Gooch TJ, Goodson SG, Gralinski LE, Hansen SDC, Heise MC, Hoel J, Lee S, Lenarcic AB, Liu EY, McMillan L, Magnuson TR, Manly KF, Miller DR, O’Brien DA, Odet F,  Pan W, Pardo-Manuel de Villena F, Perou C, Pomp D, Quackenbush CR, Robinson NN, Sharpless N, Shaw GD, Spence JS, Sullivan PF, Sun W, Tarantino LM, Valdar W, Wang J,Wang W, Welsh CE, Whitmore A, Wiltshire T, Wright FC, Xie Y, Yu ZnC, Zhabotynsky V, Zhang Z, Zou F, Powell C, Steigerwalt J, Threadgill DW, Chesler EJ, Churchill GA, Gatti DM, Svenson KL, Yang H, Shusterman A, Nashef A, Weiss EI, Houri-Haddad Y, Soller M, Schughart K, French JE, Collins FS, Crawford N, Hunter K, Kelada SNP, Peck BCE, Reilly K, Tavarez U, Bottomly D, Hitzeman R, McWeeney SK, Frelinger J, Phillippi J, Spritz RA, Benson AK, Kim J, Legge R, Low SJ, Ma F, Martinez I, Walter J, Williams RW, Aicher L, Katze M, Rosenzweig E and Broman KW (2012) The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population. Genetics 190 (2): 389-402. (Genetics and Heredity 29/165, IF 4.644: Times Cited 91). (Cover Page). Q1
  84. Welsh, CE, Miller RD, Manly KF, Wang J, McMillan L, Morahan G, Richard Mott, Iraqi FACO, Threadgill DW, Pardo-Manuel de Villena F (2012) Status and access to the Collaborative Cross population. Mammalian Genome 23:706-712. (Biotechnology & Applied Microbiology 50/165, IF 2.883: Times Cited 33).
  85. Schughart K, Libert C; SYSGENET (Iraqi FACO) consortium, Kas MJ. (2013) Controlling complexity: the clinical relevance of mouse complex genetics. Eur J Hum Genet. Nov; 21(11):1191-6. doi: 10.1038/ejhg.2013.79. ((Genetics & Heredity 30/165, IF 4.580: Times Cited). Q1
  86. Anna Delprato, Ana M Aransay, SYSGENET (Iraqi FA consortium Heike Kollmus, Klaus Schughart, Juan M Falcon-Perez (2013) Meeting report of the European mouse complex genetics network SYSGENET. Mammalian Genome 24(5-6):190-7. (Biotechnology & Applied Microbiology 50/165, IF 2.883: Times Cited 0)
  87. Shusterman A, Durrant C, Mott R, Schaefer A, Weiss EI, Iraqi FA and Houri-Haddad Y (2013) Host susceptibility to periodontitis: Mapping murine genomic regions. Journal of Dental Research 92: 438-443 (Dentistry, Oral Surgery & Medicine 2/89, IF 4.602: Times Cited 5). Q1 Iraqi FA and Houri-Haddad Y have equal contributions. Mutual PhD student (Shusterman) supervision.
  88. Shusterman A, Salymah Y, Nashef A, Soller M, Wilensky A, Mott R, Weiss EI, Houri-Haddad Y and. Iraqi FA (2013) Genotype is an important determinant factor of host susceptibility to periodontitis in the Collaborative Cross and inbred mouse populations. BMC Genetics 14: 68-79. (Genetics and Heredity 100/165, IF 2.152: Times Cited 8).  Iraqi FA and Houri-Haddad Y have equal contributions. Mutual PhD student (Shusterman) supervision.
  89. Iraqi AF, Athamni H, Dorman A, Salymah Y, Tomlinson I, Nashif A, Shusterman A, Weiss E, Houri-Haddad Y, Mott R and Soller M (2014) Heritability and coefficient of genetic variation analyses of phenotypic traits provided strong basis for high-resolution QTL mapping in the Collaborative Cross mouse reference population. Mammalian Genome. 25(3): 109-119. (Biotechnology & Applied Microbiology 83/163, IF 2.078: Times Cited 10).
  90. Soller M and Fuad Iraqi FA (2014) The Collaborative Cross – a next generation mouse genetic resource population for high resolution genomic analysis of complex traits. Livestock Sciences Journal 166: 19–25. (Livestock Production and Sciences 17/58, IF 1.293: Times Cited 0).
  91. Chalfin L, Dayan M, Levy DR, Austad AN, Miller RA, Iraqi FA, Dulac C and Kimchi T (2014) Mapping ecologically relevant social behaviours by gene knockout in wild mice. Nature Communications 5:4569 (Aug 5). doi: 10.1038/ncomms5569.PMID: 25090970. (Multidisciplinary Science 3/63, IF 11.329: Times Cited 5). Q1
  92. De Simone M, Spagnuolo L, Ivan Lorè N, Rossi G, De Fino I, Cigana C, Iraqi FA and Bragonzi A (2014) Host genetic background influences the response to the opportunistic Pseudomonas aeruginosa infection altering cell-mediated immunity and bacterial replication. PLOS One 9(9), e106873, 1-10 (Multidisciplinary Science 11/63, IF 3.057: Times Cited 4). Q1
  93. Vered K, Durrant C, Mott R and Iraqi FA (2014) Susceptibility to Klebsiella pneumonaie Infection in Collaborative Cross Mice is a Complex Trait Controlled by At Least Three Loci Acting at Different Time Points. BMC Genomics 15:865 DOI: 10.1186/1471-2164-15-865 (Biotechnology & Applied microbiology 32/161, IF 3.867: Times Cited 6). Q1 *These authors contributed equally to this work.
  94. Schaefer A, Bochenek G, Jochen As, Ellinghaus D, Dommisch H, Guzeldemir E, Graetz C, Harks I, Jockel-Schneide Y, Staufenbiel I, Eberhard J, Meyle J, Eickholz P, Linden G, Cine N, Nohutcu R, Yilmaz E, Weiss E, Houri-Haddad Y, Iraqi FA, Folwaczny M, Noack B, Strauch K, Gieger C, Waldenberger M, Peters A, Wijmenga C, Lieb W, Franke A, Rosenstiel P, Doerfer C,  Bruckmann C, CARDIoGENICS, König I, Bruno G. Loos GB, Schreiber S (2014) Genetic Evidence for PLASMINOGEN as a Shared Genetic Risk Factor of Coronary Artery Disease and Periodontitis. Circulation: Cardiovascular Genetics DOI: 10.1161/CIRCGENETICS.114.000554. (Cardiac & Cardiovascular Systems 34/124, IF 3.079: Times Cited 5).
  95. Maria Hernandez-Valladares, Pascal Rihet and Fuad A. IraqiPI (2014) Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes. Physiological Genomics 46: 1-16. (Physiology 29/81, IF 2.812: Times Cited 0)
  96. Terrence Meehan, Andrew Blake, Joanne Bottomley, Ana Castro, Sabine Fessele, Martin Fray, Janet Kenyon, Gautier Koscielny, Ann-Marie Mallon, Marzia Massimi, Raffaele Matteoni, Mike Relac, Ralph Steinkamp, Phil Wilkinson, Martin Hrabe de Angelis, Steve Brown, Glauco Tocchini-Valentini, Yann Herault, Ramiro Ramirez-Solis, George Kollias, Brun Ulfhake, Jocelyne Demengeot, Cecile Fremond, Fatima Bosch, Lluis Montoliu, Raija Soininen Paul Flicek, Klaus Schughart, Cord Brakebusch, Rülicke Sedlacek, Thomas Radislav, Colin McKerlie, Bernard Malissen, Fuad A. Iraqi, Jos Jonkers, Russig Holger, Danny Huylebroeck, Helen Parkinson, Michael Raess, Michael Hagn (2015) INFRAFRONTIER- Providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Research 43: 1171-1175. (Biochemistry & Molecular Biology 18/289, IF 9.202: Times Cited 4) Q1
  97. Dorman A, Daria Baer, Tomlinson I, Mott R and Iraqi FA (2015) Intestinal polyp development in Collaborative Cross mice carrying the ApcMin/+ mutation. American International Journal of Contemporary Scientific Research 396: 1(4), ISSN 2349-4425. (Multidisciplinary Science Primary Research 10/55, IF 3.3245).
  98. Lore’ NI, Iraqi FA and Bragonzi A (2015) Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice. BMC Genetics 16 (106) DOI 10.1186/s12863-015-0260-6. (Genetics and Heredity 100/165, IF 2.152: Times Cited 1). Iraqi FA and Bragonzi A have equal contributions and mutual supervision to Lore N.
  99. Roei Levy, Richard F Mott, Fuad A Iraqi, Yankel Gabet (2015) Collaborative cross Mice in a Genetic Association Study Reveal New Candidate Genes for Bone Microarchitecture. BMC Genomics 16:1013: 1-14 (Biotechnology & Applied microbiology 32/161, IF 3.867: Times Cited 1). Q1
  100. Mirjana Rajilić-Stojanović, Daisy M. Jonkers, Jeroen Raes, Kurt Hanevik, Anne Salonen, Jonna Jalanka, Willem M. de Vos, Chaysavanh Manichanh, Natasa Golic, Paul Enck, Elena Philippou, Fuad A. Iraqi, Gerard Clarke, Robin C. Spiller, and John Penders. (2015) Intestinal microbiota and diet in IBS: causes, consequences or epiphenomena. American Journal of Gastroenterology doi: 10.1038/ajg.2014.427. (Gastroenterology & Hepatology 6/78, IF 10.383: Times Cited 20) Q1
  101. Muhamad Abu-Hussein, Nezar Watted, Mohammad Yehia, Peter Proff and Fuad A. Iraqi (2015) Clinical Genetic Basis of Tooth Agenesis. Journal of Dental and Medical Sciences 14(12): 1-10.
  102. Abu Toamih-Atamni HJ, Mott R, Soller M and Iraqi FA (2016a) High-fat induced development of increased fasting glucose levels and impaired response to intraperitoneal glucose challenge in collaborative cross mouse reference population. BMC Genetics 17:10. DOI 10.1186/s12863-015-0321. (Genetics and Heredity 100/165, IF 2.152: Times Cited 0).
  103. Dorman A, Daria Baerr, Tomlinson I, Mott R and Iraqi FA (2016) Genetic Analysis of Intestinal polyp development in Collaborative Cross mice carrying the ApcMin/+ mutation.  BMC Genetics 17:46 DOI 10.1186/s12863-016-0349-6 (Genetics and Heredity 100/165, IF 2.152: Times Cited 0).
  104. Maura De Simone, Lorenza Spagnuolo, Nicola Ivan Lorè, Cristina Cigana, Ida De Fino, Karl W. Broman, Fuad A. Iraqi, Alessandra Bragonzi (2016) Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. BMC Genomics 17(1), December 2016. DOI: 10.1186/s12864-016-2676-4 (Biotechnology & Applied microbiology 32/161, IF 3.867: Times Cited 0). Q1 Iraqi FA and Bragonzi A have equal contributions and mutual supervision to Maura Simone  
  105. Hanifa Abu Toamih-Atamni, Maya Botzman, Richard Mott, Irit Gat-Vicks and Fuad A. Iraqi (2016b) Mapping liver fat female-dependent quantitative trait loci in collaborative cross mice. Mammalian Genome Journal 27(11), 565-573. (Biotechnology & Applied Microbiology 83/161, IF 2.078: Times Cited 0).
  106. Hanifa Abu Toamih Atamni, Mahmoud Egbaria, Yaser Salaymeh, Aysar Nashif and Fuad A. Iraqi (2016c) The Collaborative Cross mouse genetic reference population designed for dissecting complex traits. Chinese Journal of Comparative Medicine Medicine. Vol 26 (8): 1-19.
  107. Aharon Nachshon, Hanifa J. Abu-Toamih Atamni, Yael Steuerman, Roa’a Sheikh-Hamed, Alexandra Dorman, Richard Mott, Juliane C. Dohm, Hans Lehrach, Mark Sultan, Ron Shamir, Sascha Sauer, Heinz Himmelbauer, Fuad A. Iraqi, Irit Gat-Viks (2016) Dissecting the effect of genetic variation on the hepatic expression of drug disposition genes across the collaborative cross. Frontiers in Genetics. 05 October, volume 7: 1-12: 10.3389/fgene. 2016.00172. (Genetics and Heredity, IF 3.92) Q1 Fuad A. Iraqi and Irit Gat-Vicks have equal contributions.
  108. Abu Toamih-Atamni HJ, Yaron Zinar, Richard Mott, Lior Wolf, and Iraqi FA (2017a) Glucose tolerance female-specific QTL mapped in collaborative cross mice. Mammalian Genome Journal. 28:20–30. DOI. 10.1007/s00335-016-9667-2. (Biotechnology & Applied Microbiology 83/161, IF 2.078).
  109. Dorman A, Daria Baer, Tomlinson I, Mott R and Iraqi F (2016) Erratum to: Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc Min/+ mutation. BMC Genetics 17:46. DOI 10.1186/s12863-016-0456-4.
  110. A. Shusterman, M. Munz, G. Richter, S. Jepsen, W. Lieb, B. Krone, P. Hoffman, M. Laudes, J. Wellmann, K. Berger, T. Kocher, S. Offenbacher, K. Divaris, A. Franke, S. Schreiber, H. Dommisch, E. Weiss, A.S. Schaefer, Y. Houri-Haddad, and F.A. Iraqi. (2017) The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis. Journal of dental Research. First Published May 3, 2017. DOI: 10.1177/0022034517706311. (Dentistry, Oral Surgery & Medicine 1/89, IF 4.602). Q1
  111. Aysar Nashef, Hanifa Abu-Toamih Atamni, Yuval Buchnik, Hatice Hasturk, Alpdogan Kantarci, Danielle Stephens, Ervin I. Wiess, Yael Houri-Haddad and Fuad A. Iraqi (2017) Collaborative Cross mouse population for studying the alveolar bone changes and impaired glucose tolerance comorbidity after high fat diet consumption. Journal of Periodontology. Sep;88(9):e150-e158. doi: 10.1902/jop.2017.170075. Epub 2017 May 19. (Dentistry, Oral Surgery & Medicine 17/89, IF 2.084).
  112. Hanifa Abu Toamih-Atamni, Maya Botzman, Richard Mott, Irit Gat-Vicks and Fuad A. Iraqi (2017b) Mapping Quantitative Trait Loci underlyining liver weigh using collaborative cross mouse genetic reference population. Journal of Advances in Biology 10(2): 1-12.
  113. Aysar Nashef, Yaser Salaymeh, Rawan Quabaja, Matthias Munz, Maya Botzman, Wolfgang Lieb, Bastian Krone, Per Hoffman, Matthias Laudes, Jürgen Wellmann, Klaus Berger, Thomas Kocher, Steven Offenbacher, Kimon Divaris, Andre Franke, Henrik Dommisch, Richard Mott,  Irit Gat-Viks, Erwin Weiss, Arne Schaefer, Fuad A. Iraqi  and Yael Houri-Haddad (2018) Integration of Murine and Human studies for Mapping periodontitis susceptibility. Journal of Dental Research 97(5): 537-546. 1:22034517744189. doi: 10.1177/0022034517744189
  114. Neri Kafkafi, Joseph Agassi, Elissa J. Chesler, John C. Crabbe, Wim E. Crusio, David Eilam, Robert Gerlai, Ilan Golani, Alex Gomez-Marin, Ruth Heller, Fuad Iraqi, Iman Jaljule, Natasha A. Karp, Hugh Morgan, George Nicholson, Donald W. Pfaff, Helene Richter, Philip B. Stark, Oliver Stiedl, Victoria Stodden, Lisa Tarantino, Valter Tucci, William Valdar, Robert W. Williams, Hanno Würbel, Yoav Benjamini (2018) Reproducibility and replicability of mouse phenotyping in preclinical studies. Neuroscience and Biobehavioral Reviews. Volume 87, April, Pages 218-232.
  115. Hanifa Abu Toamih-Atamni, Aysar Nashef and Fuad A. Iraqi (2018) The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases. Mammalian Genome 29:471–487.
  116. Abu-Toamih Atamni HJ, BotzmanM, Mott R, Gat-Viks I, Iraqi FA. (2018) Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice. Animal Model for Experimental Medicine Journal. 1: 212–220. https://doi.org/10.1002/ame2.12036
  117. Remco T. Molenhuis, Hilgo Bruining, Myrna J.V. Brandt, Petra E. van Soldt, Hanifa J. Abu-Toamih Atamni, J. Peter H. Burbach, Fuad A. Iraqi, Richard F. Mott & Martien J.H. Kas (2018) Modeling the quantitative nature of neurodevelopmental disorders using Collaborative Cross mice. Molecular Autism 9:63-1-11. https://doi.org/10.1186/s13229-018-0252-2.
  118. Amit Frishberg, Naama Peshes-Yaloz, Ofir Cohn, Diana Rosentul, Yael Steuerman, Liran Valadarsky, Gal Yankovitz, Michal Mandelboim, Fuad A. Iraqi, Ido Amit, Lior Mayo, Eran Bacharach and Irit Gat-Viks (2019) Cell composition analysis of bulk genomics using single cell data. Nature Methods Vol 16 (April), 327-332.
  119. Hanifa J. Abu‐Toamih Atamni and Fuad A. Iraqi (2019) Efficient protocols and methods for high‐throughput utilization of the Collaborative Cross mouse model for dissecting the genetic basis of complex traits. Animal Models for Experimental Medicine (AMEM). Published in July: DOI: 10.1002/ame2.12074.
  120. Nicola I Lorè, Barbara Sipione, Gengming He, Lisa J Strug, Hanifa J Atamni, Alexandra Dorman, Richard Mott, Fuad A. Iraqi, and Alessandra Bragonzi (2019) Collaborative Cross mice yield genetic modifiers for Pseudomonas aeruginosa infection in human lung disease. Mbio Journal (Submitted)
  121. Roei Levy, Keren Cohen, Clemence Levet, Matthew Freeman, Richard Mott, Fuad A. Iraqi, Yankel Gabet (2019) Genome-wide association study in Collaborative Cross mice reveals a role for Rhbdf2 in skeletal homeostasis. Scientific Reports (Resubmitted)
  122. Abu-Toamih Atamni HJ., Kontogianni G., Binenbaum I., Mott R., Himmelbauer H., Lehrach H., Chatziioannou A., Iraqi FA. (2019) Hepatic gene expression variations in response to diet-induced impaired glucose tolerance using the Collaborative Cross mouse population. Mammalian Genome. (submitted)   
  123. Aysar Nashef, Munz Matthias, Ervin Weiss, Bruno G. Loos, Søren Jepsen, Nathalie van der Velde, André G. Uitterlinden, Jürgen Wellmann, Klaus Berger, Per Hoffmann, Matthias Laudes, Wolfgang Lieb, Andre Franke, Henrik Dommisch, Arne Schäfer, Yael Houri-Haddad and Fuad A. Iraqi (2019) Translation of a mouse model of periodontitis to humans using RNA-sequencing and genetic association studies gives novel insights into the disease aetiology. Scientific Reports. (Submitted)
  124. Ilona Binenbaum, Hanifa Abu-Toamih Atamni, Giorgos Fotakis, Georgia Kontogianni, Theodoros Koutsandreas, Eleftherios Pilalis, Richard Mott, Heinz Himmelbauer, Fuad A. Iraqi and Aristotelis Chatziioannou (2019). Container-aided Integrative QTL and RNA-seq Analysis of Collaborative Cross Mice Supports Distinct Sex-Oriented Molecular Modes of Response in Obesity. BMC Genomics (Submitted).
  125. Morris Soller, Hanifa J. Abu-Toamih Atamni, Ilona Binenbaum, Aristotelis Chatziioannou, and Fuad A. Iraqi (2019). Designing a QTL mapping study for implementation in the realized Collaborative Cross genetic reference population Current Protocols in Mouse Biology (CPMB) Journal. (Accepted). 

 

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