Prof. Ehud[Udi] Qimron

Full Professor, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine

 

2016 - date - Full Professor

2012 - 2016 - Associate Professor

2009 - 2012 - Senior Lecturer

2004 - 2009 - Postdoctorate - Harvard Medical School

2000 - 2004 - Ph.D. (direct track) - Ben Gurion University

1998 - 2000 - B.Sc. (summa cum laude) - Ben Gurion University

Our lab studies the adaptive immune system of bacteria: the CRISPR-Cas. This fascinating system specifically adapts to defend prokaryotes against newly encountered phages by launching a specific RNA-guided attack against their nucleic acids. We also study novel phage interactions with their bacterial hosts, and particularly interactions with defense systems such as CRISPR-Cas. These basic studies are translated to projects aiming at reversing antibiotic resistance and consequently countering the threat from antibiotic-resistant pathogens.

Yosef I, Goren MG, Globus R, Molshanski-Mor S, and Qimron U.

Extending the host range of bacteriophage particles for DNA transduction.

Molecular Cell, 66(5):721-728, 2017.

Cover page – Molecular Cell June 1^st 2017.

 

Goren MG, Doron S, Globus R, Amitai G, Sorek R, and Qimron U.

Repeat size determination by two molecular rulers in the type I-E CRISPR array

Cell Reports, 16(11):2811-8, 2016

 

Yosef I, Edgar R, Levy A, Amitai G, Sorek R, Munitz A, and Qimron U.

Natural selection underlies apparent stress-induced mutagenesis in a bacteriophage infection model

Nature Microbiology (letter), 1(6):16047, 2016.

 

Yosef I, Manor M, Kiro R, and Qimron U.

Temperate and lytic bacteriophages programmed to sensitize and kill antibiotic-resistant bacteria.

Proc Natl Acad Sci USA, 112(23):7267-7272, 2015.

 

Levy A^*, Goren MG^*, Yosef I, Auster O, Manor M, Amitai G, Edgar R, Qimron U^{†, #,} Sorek R^†,# *contributed equally; ^†joint supervision of work; ^#corresponding author

Spacer acquisition biases explain preference for foreign DNA in CRISPR adaptation

Nature (article), 520(7548):505-510, 2015.

 

Molshanski-Mor S, Yosef I, Kiro R, Edgar R, Manor M, Gershovits M, Laserson M, Pupko T, and Qimron U.

Revealing Bacterial Targets of Growth Inhibitors Encoded by Bacteriophage T7

Proc Natl Acad Sci USA, 111(52):18715–18720, 2014.

 

Kiro R, Molshanski-Mor S, Yosef I, Milam SL, Erickson HP, and Qimron U.

Gene product 0.4 increases bacteriophage T7 competitiveness by inhibiting host cell division

Proc Natl Acad Sci USA, 110(48):19549-54, 2013

 

Yosef I, Shitrit D, Goren MG, Burstein D, Pupko T, and Qimron U

DNA motifs determining the efficiency of adaptation into the Escherichia coli CRISPR array.

Proc Natl Acad Sci USA, 110(35):14396-401, 2013

 

Yosef I, Goren MG, and Qimron U

Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli.

Nucleic Acids Research, 40(12):5569-76, 2012

 

Yosef I, Goren MG, Kiro R, Edgar R, and Qimron U

HtpG is essential for activity of the Escherichia coli CRISPR/Cas system.

Proc Natl Acad Sci USA, 108(50):20136-41, 2011

 

Selected Reviews/Editorials:

Globus R and Qimron U

Crystal-clear memories of a bacterium.

Science, 357(6356), 6-7, 2017.

 

Sternberg S, Richter H, Charpentier E, and Qimron U.

Adaptation in CRISPR-Cas systems

Molecular Cell, 61(6):797-808, 2016. 

 

Goren MG, Yosef I, and Qimron U.

Programming bacteriophages by swapping their specificity determinants

Trends in Microbiology, 23:744-746, 2016. 

 

Yosef I and Qimron U.

Microbiology News and Views: How bacteria get spacers from invaders.

Nature, 519(7542):166-167, 2015.

 

 

Last updated December 2017.