New research published by Prof. Gil Ast

updated: 24.02.2022

Gene architecture directs splicing outcome in separate nuclear spatial regions


Tammer L, Hameiri O, Keydar I, Roy VR, Ashkenazy-Titelman A, Custódio N, Sason I, Shayevitch R, Rodríguez-Vaello V, Rino J, Lev Maor G, Leader Y, Khair D, Aiden EL, Elkon R, Irimia M, Sharan R, Shav-Tal Y, Carmo-Fonseca M, Ast G.


Published in Molecular Cell


  • Differences in subnuclear regions determines alternative splicing
  • Exon-intron GC content differs in these subnuclear regions
  • Most compelling, this research creates a link between 3D genome organization and splicing


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