Dr. Yankel Gabet

אנטומיה ואנתרופולוגיה סגל אקדמי בכיר
Dr. Yankel Gabet
Phone: 03-6407684
Another phone: 03-6407628
Fax: 03-6407628
Office: Sackler School of Medicine, 639

Positions

Senior Lecturer, Department of Anatomy & Anthropology, Sackler Faculty of Medicine, Tel Aviv University

 

Research

Genetics: Our laboratory focuses on the genetic and hormonal regulation of bone remodeling, microarchitecture and strength. These traits have a high degree of heritability, and one aspect of our research is to characterize new genetic determinants of bone remodeling as well as elucidate the mechanism of action of selected genes. Our GWAS confirmed the role of AVP (vasopressin) and OXT (precursor of oxytocin) in bone and identified for the first time Rhbdf2 as a significant determinant of bone structure.

 

Sex hormones: We investigate the actions of sex hormones with an emphasis on the skeletal dimorphism between males and females, and their interaction with other genes and transcription factors.

 

Erythropoietin: Epo is the main hormone that regulates blood cells production. We are investigating the role of Epo in bone remodeling in general and on the bone cells in particular.

 

Inflammation-induced osteolysis: Today, most dental implants undergo surface roughening to enhance osseointegration. However, ultrasonic scaling performed routinely for oral hygiene releases particles from titanium implants. We found that these particles stimulate the secretion of inflammatory cytokines and induce osteoclastogenesis in vitro and in vivo.

 

Cannabinoids: Cannabis-derived and endogenous cannabinoids are important regulators of bone cells. We investigate the beneficial actions of cannabinoids in bone fracture healing, osteoporosis, Osteogenesis Imperfecta, and inflammation-induced bone destruction.

 

Publications & Grants

Grants

  • 2012-2017  Israel Science Foundation (ISF) Grant
  • 2015-2016  American Society for Bone and Mineral Research GAP Award
  • 2015-2017  American Society for Bone and Mineral Research GAP Award
  • 2015-2016  Y.D. Investments Ltd
  • 2015-2017  Kalytera Therapeutics Ltd
  • 2016-2017  Israel Cancer Association (co-PI)

 

Publications

Frenkel B, Hong A, Baniwal SK, Coetzee GA, Ohlsson C, Khalid O, Gabet Y. (2010) Regulation of adult bone turnover by sex steroids. J Cell Physiol., 2:305-310.

 

Baniwal SK, Khalid O, Gabet Y, Shah RR, Purcell DJ, Mav D, Kohn-Gabet AE, Shi Y, Coetzee GA, Frenkel B. (2010) Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. Mol Cancer, 9:258.

 

Gabet Y, Leclerc N, Baniwal SK, Shi Y, Kohn-Gabet AE, Cogan J, Dixon A, Chavez M, Guo L, Turman JE-Jr, Frenkel B. (2010) Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass. Blood,
116:3964-71.

 

Gabet Y, Noh T, Lee C, Frenkel B. (2011) Developmentally-regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin a transcription in primary osteoblast cultures. J Cell Physiol., 226:991-8.

 

Baniwal SK, Shah PK, Shi S, Haduong JH, DeClerck Y, Gabet Y, Frenkel B. (2011) Runx2 promotes both osteoblastogenesis and novel osteoclastogenic signals in ST2 mesenchymal progenitor cells. Osteoporos Int., 23:1399-1413.

 

Gabet Y, Bab I. (2011) Microarchitectural changes in the aging skeleton. Curr Osteopor Rep. 9:177-83.

 

Yen HY, Gabet Y, Liu Y, Martin A, Wu N, Pike MC, Frenkel B, Maxson R, Dubeau L. (2012) Potential consequences of the BRCA1 mutation carrier state on estrogen responsive organs. Lab Invest. 92:802-11.

 

Artsi A, Cohen-Kfir E, Gurt I, Shahar R, Bajayo A, Kalish N, Bellido T, Gabet Y, Dresner-Pollak R. (2014) The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. Endocrinology 155:3508-15.

 

Dolkart O, Liron T, Chechik O, Somjen D, Brosh T, Maman E, Gabet Y. (2014) Statins enhance Rotator Cuff healing by stimulating the COX2/PGE2/EP4 pathway in a rat model: an in vivo and in vitro study. Am J Sports Med. 42:2869-76.

 

Hiram-Bab S, Liron L, Deshet-Unger N, Mittelman M, Gassmann M, Rauner M, Franke K, Wielockx B, Neumann D, Gabet Y. (2015) Erythropoietin directly stimulates osteoclast precursors and induces bone loss. FASEB J. pii: fj.14-259085.

 

Martin A, Xiong J, Koromila T, Chang S, Song YS, Krum SA, Gabet Y, Frenkel B. (2015) Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone 75:96-104

 

Kogan NM, Bajayo A, Wasserman E, Raphael B, Breuer A, Stok KS, Villarreal Escudero AV, Sondergaard R, Attar-Namdar M, Friedlander- Barenboim S, Mechoulam R, Müller R, Melamed E, Gabet Y*, Bab I. (2015) Cannabidiol, a major non-psychotrophic cannabis constituent enhances fracture healing and stimulates lysil hydroxylase activity in osteoblasts. J Bone Min Res. 30:1905- 1913. *corresponding author.

 

Elsner JJ, Shemesh M, Shefy-Peleg A, Gabet Y, Zylberberg E, Linder-Ganz E. (2015) Quantification of in vitro wear of a synthetic meniscus implant using gravimetric and micro-CT measurements. J Mech Behav Biomed Mater., 49:310-320.

 

Barak S, Iezzi G, Neuman M, Piattelli A, Perrotti V, Gabet Y. (2015) A new device for improving dental implants anchorage: a histological and microcomputed tomography study in the rabbit. Clinical Oral Implants Research, Epub.

 

Garfinkel BP, Arad S, Le PT, Bustin M, Rosen CJ, Gabet Y*, Orly J*. (2015) Proportionate dwarfism in mice lacking heterochromatin protein 1 binding protein 3 (HP1BP3) is associated with alterations in the endocrine IGF-1 pathway. Endocrinology. Accepted, ePub.

 

Hershkovitz I, Weber GW, Fornai C, Gopher A, Barkai R, Slon V, Quam R, Gabet Y and Sarig R. New Middle Pleistocene dental remains from Qesem Cave (Israel). Quaternary International, accepted ePub.

 

Barak S, Iezzi G, Neuman M, Piattelli A, Perrotti V, Gabet Y. (2015) A new device for improving dental implants anchorage: a histological and microcomputed tomography study in the rabbit. Clinical Oral Implants Research, Epub.

 

Raphael B, Gabet Y. (2015) The skeletal endocannabinoid system: clinical and experimental insights. J Basic Clin Physiol Pharmacol. ePub; Accepted.

 

Levy R, Mott RF, Iraqi FA, Gabet Y. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture. (2015) BMC Genomics; 16:1013.

 

Kogan NM, Bajayo A, Wasserman E, Raphael B, Breuer A, Stok KS, Villarreal Escudero AV, Sondergaard R, Attar-Namdar M, Friedlander- Barenboim S, Mechoulam R, Müller R, Melamed E, Gabet Y*, Bab I. (2015) Cannabidiol, a major non-psychotrophic cannabis constituent enhances fracture healing and stimulates lysil hydroxylase activity in osteoblasts. J Bone Min Res. 30:1905- 1913. *corresponding author.

 

Bell RE, Golan T, Sheinboim D, Malcov H, Amar D, Salamon A, Liron T, Gelfman S, Gabet Y, Shamir R, Levy C. (2016) Enhancer methylation dynamics contribute to cancer plasticity and patient mortality. Genome Research; 26:601-11.

 

Masarwi M, Gabet Y, Dolkart O, Brosh T, Shamir R, Phillip M, Gat-Yablonski G. (2016) Skeletal effect of casein and whey protein intake during catch-up growth in young male Sprague-Dawley rats. Br J Nutr. 116:59-69.

 

Raygorodskaya M, Gabet Y, Shochat C, Kobyliansky E, Torchinsky A, Karasik D. (2016) Intrauterine stress induces bone loss in adult offspring of C3H/HeJ mice having high bone mass phenotype but not C57BL/6J mice with low bone mass phenotype. Bone; 87, 114-119.

 

Hiram-Bab S, Neumann N, Gabet Y. (2016) Erythropoietin in bone - Controversies and consensus. Cytokine. Accepted Jan 2016.

 

Rauner M, Franke K, Murray M, Singh RP, Hiram- Bab S, Platzbecker U, Gassmann M, Socolovsky M, Neumann D, Gabet Y, Chavakis T, Hofbauer LC, Wielockx B. (2016) Increased EPO Levels Are Associated with Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells. J Bone Miner Res; Accepted Apr 2016. 

 

Gabet Y, Bab I. A validated method for titanium implant anchorage analysis using microct and biomechanical testing biological sciences. Adv Tech Biol Med. Accepted June 6, 2016.

 

Deshet-Unger N, Hiram-Bab S, Haim-Ohana Y, Mittelman M, Gabet Y, Neumann D. Erythropoietin treatment in murine multiple myeloma: immune gain and bone loss. Scientific Reports, Accepted July 2016.

 

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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