Dr. Mordechai Gerlic's Paper on the Cover of The FEBS Journal

Congratulations to Dr. Gerlic

10 February 2019
On the cover - Inhibiting necroptosis in IL-33-dependent allergic airway inflammation – anti-necroptosis treated (left) vs untreated (right) lung.

IL-33 is a pro-inflammatory cytokine that plays a role in a range of inflammatory diseases. To date, the mechanism underlying its release in cells is not fully understood.

 

A recent work led by MD/PhD student Inabr Shlomovitz and Dr. Motti Gerlic demonstrate that necroptosis, a form of cell death, triggers the release of IL-33 in its bioactive form. Inhibition of necroptosis in an Aspergillus allergic asthma model results in reduced inflammation, providing in vivo evidence that necroptosis contributes to IL-33-associated inflammatory disease.

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