Molecular Basis of Visual System Development

We study the gene networks that transform the embryonic cells into a complex, differentiated organ. We focus on exploring this question by studying the process of eye development as a model for organogenesis.

We apply cutting-edge technologies including mouse genetic tools (Cre/loxP), molecular biology, and microarray analysis to identify and functionally characterize genes that regulate the development of the eye in mammals.

Understanding the normal developmental regulation of the different eye structures is essential for understanding visual disorders and designing treatments for ocular phenotypes including retinal degeneration, glaucoma and cataracts, all of which are leading causes of blindness.