Dr. Jason Friedman, Ph.D.
Department of Physical Therapy
Research
Prof. Ruth Ashery-Padan, Ph.D.
Department of Human Molecular Genetics and Biochemistry
We study the gene networks that transform the embryonic cells into a complex, differentiated organ. We focus on exploring this question by studying the process of eye development as a model for organogenesis.
We apply cutting-edge technologies including mouse genetic tools (Cre/loxP), molecular biology, and microarray analysis to identify and functionally characterize genes that regulate the development of the eye in mammals.
Understanding the normal developmental regulation of the different eye structures is essential for understanding visual disorders and designing treatments for ocular phenotypes including retinal degeneration, glaucoma and cataracts, all of which are leading causes of blindness.
Research
Dr. Yaron Carmi
Department of Pathology
Research
Prof. Arieh S. Solomon, M.D., Ph.D.
Goldschleger Eye Research Institute
Department of Ophthalmology
The eye presents many challenges for research regarding unsolved conditions such as retinal and optic nerve assaults, damage to eye by surrounding conditions of work and every day activity.
The following specific subjects are studied:
- Optic nerve research: creating models of trauma and disease to investigate the mechanisms of degeneration and regeneration
- Investigate ways to treat corneal injury and diseases
- Ultraviolet light damage to the eye
- Research on the neovascular process in the eye and search ways to prevent it
- Occupational and environmental factors affecting eye and vision
Grants
2012-2015 | European Union FP7 |
Research
Dr. Inna Slutsky, Ph.D.
Department of Physiology and Pharmacology
The research in the laboratory is focused on understanding the basic mechanisms underlying synaptic function and primary mechanisms initiating synaptic dysfunction at very early stages of Alzheimer’s Disease. To achieve this goal, we developed an integrated system that enables simultaneous real-time visualization of structural reorganization in spatially-restricted signaling complexes and functional modifications of single synapses in brain circuits.
Utilizing FRET spectroscopy, high-resolution optical imaging, electrophysiology, molecular biology, and biochemistry we explore experience-dependent mechanisms regulating the number and plasticity of hippocampal synapses under physiological and pathological conditions.
Grants
2011-2016 | Evolution of Alzheimer’s Disease: From Dynamics of Single Synapses to Memory Loss, European Research Council Starting Grant. |
Research
Prof. Moshe Rehavi, Ph.D.
Department of Physiology and Pharmacology
Main projects in the lab include:
- Presynaptic monoamine transportes and the vesicular monoamine transporter as targets for neuropsychiatric drugs.
- Anxiolytic effects of new herbal treatment: mice models of anxiety and biochemical studies.
- Quaternary serotonin-reuptake inhibitors as novel anti-platelet drugs.
- Methylphenidate (Ritalin): abuse potential and long-term effects.
- Neuronal rescue by Rasagiline (MAO-B inhibitor) in thiamine deficiency.
Research
Prof. Chaim G. (Chagi) Pick, Ph.D.
Department of Anatomy and Anthropology
My group has a long history in mTBI research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of translational relevance to support the development of new treatment strategies and drugs. In order to look for answers regarding the blast induced traumatic brain injury, we have developed a blast injury model for mice that resembles, as much as possible, the conditions on the battlefield or at a terror-attack site. As such, the outcomes of the “real-life-like” exposure to the blast in our model may vary from severe to mild brain injury under controlled conditions for each mouse.
Research
Dr. Eran Perlson, Ph.D.
Department of Physiology and Pharmacology
The lab is a new multi-disciplinary molecular and cellular neurobiology lab. The lab uses state-ofthe- art single molecule live imaging techniques on neuronal cultures, as well as biochemistry, cell biology and biophysics approaches on mouse model systems to study the role of axonal transport in neurodegenerative diseases, with an initial focus on ALS.
Neuronal survival and proper function depends on cell-cell communication mediated by ligandreceptor mechanisms. During neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), there is considerable synapse/neuromuscular junction (NMJ) disruption and neuronal cell death. It is non-autonomous processes involve interactions between the neurons to its diverse extracellular microenvironments. The molecular basis for this neuronal dysfunction and death is still poorly understood. One possible reason is alterations in the nature, directed movement and spatial localization of vital extra and intracellular signals.
The long-term research goal of the lab is to understand the vital molecular communications mechanisms between the neurons and its environment. More specifically, we seek to understand the role that retrograde signaling plays in (1) neuronal survival and (2) synapse stability. We believe that our research will generate novel insights into neurodegenerative mechanisms and ultimately, provide a molecular basis for new drugs as well as delivery methods to treat a range of neurodegenerative diseases.
Grants
2011-2015 | ISF (Israel Science Foundation), The Dual Role of Dynein in GDNF Signaling |
2011-2015 | Marie Curie International Reintegration Grants (IRG), Retrogade Signaling. |
2013-2016 | Small Molecule Screen for Neuromuscular Junction Maintenance, Rosetrees Trust |
2013-2016 | E-Rare-2, European Research Projects on Rare Diseases driven by Young Investigators. Project Coordinator. The Molecular Basis of Neurodegeneration and Muscle Atrophy in ALS. (Co-PIs: Roded Sharan, TAU; Edgar Gomes, U of Paris; Marcus Kruger, Max Planck; Del Bene Fillippo, Ins Curie; Alberto Rodendo, 12th Oct Uni Hospital Madrid) |
2013-2018 | Molecular Communication Mechanism of Motor Neuron Survival and Synapse Maintenance, European Research Council (ERC) Starter Grant |
Research
Dr. Moshe Parnas, Ph.D.
Department of Physiology and Pharmacology
We are exploring the various mechanisms by which neural circuits encode information and support behavior, learning and memory. In addition, we are studying how the connectivity and activity of such circuits and neural networks are affected by molecular mechanisms underlying brain disorders. We use a multidisciplinary approach, with the Drosophila olfaction system as our model system. Our studies incorporate in vivo whole cell patch recordings, in vivo functional imaging, behavior experiments, molecular biology, mathematical modelling and genetics.
Projects in the lab include:
- Intensity and identity coding in a multidimensional sensory system – the Drosophila olfactory system.
- Neuropeptidergic modulation of olfaction and its effect on odour perception.
- The role of deregulated channel proteins and altered neuronal function in Frontotemporal Dementia.
- A novel multifaceted approach to study the mechanisms underlying the effects of human genes associated with schizophrenia using Drosophila.