Prof. Chaim Pick

אנטומיה ואנתרופולוגיה סגל אקדמי בכיר
Prof. Chaim Pick
Phone: 03-6409247
Fax: 03-6408287
Office: Sackler School of Medicine, 633

Positions

Professor, Department of Anatomy & Anthropology, Sackler Faculty of Medicine

Research

Brain Injuries: Cognitive, Behavioral and Cellular Outcome

My group has a long history in mTBI research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of translational relevance to support the development of new treatment strategies and drugs. In order to look for answers regarding the blast induced traumatic brain injury, we have developed a blast injury model for mice that resembles, as much as possible, the conditions on the battlefield or at a terror-attack site. As such, the outcomes of the “real-life-like” exposure to the blast in our model may vary from severe to mild brain injury under controlled conditions for each mouse.

 

Recent Publications

Rubovitch V, Edut S, Sarfstein R, Werner H, Pick, C.G. The intricate involvement of the insulin-like growth factor receptor signaling in mild traumatic brain injury in mice. Neurobiol Dis 38:299-303 (2010).

 

Baratz, R., Rubovitch, V., Frenk, H. and Pick, C.G. The Influence of Alcohol on behavioral recovery following mTBI in mice. J Neurotrauma 27:555-63 (2010).

 

Defrin R, Gruener, H, Schreiber, S and Pick C.G, Quantitative somatosensory testing of subjects with chronic post traumatic headache: implications on its mechanism. Eur J Pain 14:924-31 (2010).

 

Katzav, A., Faust-Socher, A., Kvapil, F., Michaelson. D.M., Blank, M., Pick C.G., Shoenfeld, Y., Korczyn, A., Chapman, J. Antiphospholipid syndrome induction exacerbates a transgenic alzheimer disease model on a female background. Neurobiol Ageing 32: 272- 279 (2011).

 

Zohar O., Lavy R., Zi X., Nelson T.J., Hongpaisan J., Pick C.G., Alkon D.L. PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiol of Dis 41: 329-337 (2011).

 

Shen, H, Harvey, B.K, Chiang, Y-H, Pick C.G, Wang, Y. Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice. Brain Res 1368: 248- 253 (2011). *Equal contribution

 

Benaroya-Milshtein, N., Hollander, N., Apter, A., Yaniv, I., Pick, C.G. Stress conditioning in mice: alterations in behavior, immunity and tumor growth. Stress 14:301-311(2011).                                                                                                                                        

 

Edut S., Rubovitch, V., Schreiber, S., Pick C.G. The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI). Psychopharmacol214: 877-889 (2011).

 

Rubovitch, V., Werner H, and Pick C.G. The neuroprotective effect of IGF-1 administration after a mild traumatic brain injury in mice is mediated by the adaptive arm of ER stress. Neurochem Internat 58: 443-446 (2011).

 

Zohar, O., Rubovitch, V., Milman, A., Schreiber, S., Pick C.G. Behavioral Consequences of Minimal Traumatic Brain Injury in Mice. Acta Neurobiologiae Experimentalis 71:36-45 (2011).

 

Rubovitch, V. Ten-Bosch, M., Zohar, O., Harrison, C., Tempel-Brami, C., Stein, E., Hoffer, B.J., Balaban, C.D., Schreiber, S., Chiu, W.T. and Pick C.G. A Mouse Model of Blast-Induced mild Traumatic Brain Injury. Exp Neurology, 232:280-89 (2011).

 

Baratz, R., Tweedie, D., Rubovitch, V., Greig N.H., Pick, C.G. Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J Neurochem. 118:1032-42. (2011)

 

Domachevsky, L., Pick C.G. Arieli, Y., Krinsky, N., Abramovich, A. and Eynan, M. Do hyperbaric oxygen-induced seizures cause brain damage? Epilepsy Res. 100:37-41 (2012).

 

Saykally, J.N., Rachmany, L., Hatic, H., Shaer, A., Rubovitch, V., Pick, C.G. and Citron, B.A. The Nrf2 activator, tert-butylhydroquinone (tbhq), improves cognitive performance in mice after mild traumatic brain injury. Neuroscience, 223: 305-314 (2012).

 

Rachmany, L., Tweedie D., Li, Y., Rubovitch, V., Holloway, H.W., Miller, J., Hoffer, B.J., Greig, N.H. and Pick, C.G. Exendin-4 Induced Glucagon-like Peptide-1 Receptor Activation Reverses Behavioral Impairments of Mild Traumatic Brain Injury in Mice. Aging 35:1621-36 (2013).

 

Tweedie, D,. Rachmany, L., Rubovitch, V., Lehrmann, E., Zhang, Y., Backer, K.G., Parez, E., Miller, J., Hoffer, B.J., Greig, N.H. and Pick, C.G. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice. Exp. Neurology, 239:170-82 (2013).

 

Menachem, A., Chapman, J., Deri, Y., Pick, G.C. and Katzav, A. Immunoglobulin mediated neuro-cognitive impairment: review and preliminary experimental findings. Clinical Reviews in Allergy & Immunology 45:62-68 (2013).

 

Woods, A.S., Colsch, B., Jackson, S.N., Post, J., Baldwin, C., Roux, A., Hoffer, B.J., Cox, B., Hoffer M., Rubovitch,V. Pick, C.G. J.A., Schultz. and Balaban, C. Gangliosides and ceramides changes in a mouse model of a blast induced traumatic brain injury. ACS Chemical Neuroscience 17:594-600 (2013).

 

Domachevsky, L., Pick, C. G., Peled, N., Gomori, J.M., Abramovich, A. and Tempel-Brami, C. MRI Findings after Hyperbaric Induced Seizures. Epilepsy Res 105: 62-68 (2013).

 

Tweedie, D., Rachmany, L., Rubovitch, V., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J., Pick, C.G. and Greig, N.H. Physical- versus Blast-Traumatic Brain Injury: commonalities in cognitive dysfunction and hippocampal gene transcriptome in mice. Neurobiol Dis 54:1-11 (2013).

 

Katzav, A., Ginsburg, D., Evert, T., Blank, M., Pick, C.G., Shoenfeld, Y. and Chapman, J. Coagulopathy Triggered Autoimmunity: Experimental Antiphospholipid Syndrome in Factor V Leiden Mice. BMC Medical 11:92  (2013).

 

Domachevsky, L., Rachmany, L., Barak, Y.,Rubovitch, V., Abramovich, A. and Pick, CG. Do hyperbaric oxygen-induced seizures cause a transient decrement   in cognitive function. Neuroscience. 247: 328-334 (2013).

 

Rachmany, L., Tweedie, D., Rubovitch, V., Yu, Q., Wang, J.Y., Pick, C.G.*, Greg, N.H*. Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-a. PLoS One 28;8(11) (2013).

 

Schreiber, S., Hostovsky, A., Volis, I., Rubovitch, V. Pick, CG. The impact of antidepressant drugs on the antinociceptive properties of methadone in mice. J. Molec Neurosci 52: 598-604 (2014).                              

 

Benaroya-Milshtein, N., Apter, A., Yaniv, I., Oded, Y., Stern, B., Bengal, Y., Kodman, Y., Shemer, E., Pick, G.C., Buchwald I. and Valevski A. Neuroimmunological function in parents of children suffering from cancer. J Neural Transmission 121: 299-306 (2014).

 

Itsekson, Z., Shavit-Stein, E., Weissberg, I., Katzav,A., Rubovich, V., Friedman, A., Pick C.G. and J. Chapman.  Increased Levels of Thrombin and its Receptor PAR-1 in Minimal Traumatic Brain Injury in Mice. J. Molec Neurosci 53: 87-95 (2014).

 

Greg, N.H, Tweedie, D. Rachmany, L., Yu, Q., Rubovitch, V, Schreiber,S.,  Chiang, Y-H. Hoffer, B.J., Lahiri, D., Kumar Sambamurti, K., Becker,R.E., Pick, C.G. Incretin mimetics as pharmacological tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimer's & Dementia 10: S62-S75 (2014).  

 

Eakin, K., Baratz-Goldstein, R., Pick, C.G., Zindel, O., Hoffer, B.J., Balaban, C., Hoffer, M.E. Lockwood, M. Miller, and Hoffer, B.J.  J. Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury. PLoS One 16;9 (2014).

 

Katzav, A., Ben-Ziv, T., Blank M. Pick, C. G., Shoenfeld Y and Chapman, J. Antibody-specific
behavioral effects: Intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice. J Neuroimmunol, 272:10-15(2014).

 

Schreiber, S., Lin, R., Haim, L., Baratz-Goldstien, R., Rubovitch, V., Waisman, N. and Pick, C. G. Enriched environment improves the cognitive effects from traumatic brain injury in mice. Behav Brain Res 271:59-64 (2014).

 

Lloyd, MC. Burke, N. Kalantapour, F. Niesen, MI. Hall, A. Pennypacker, K. Citron, B. Pick, C. G. Vernard A, V. Das, M. Mohapatra, S. Cualing, H and Blanck, G. Quantitative morphological and molecular pathology 1 of the human thymus correlate with infant cause of death. Tech. Innovation 16: 55-62 (2014).

 

Edut S., Rubovitch, V., Rehavi, M., Schreiber, S. and Pick, C. G. A study on the mechanism by which MDMA protects against dopaminergic dysfunction after minimal traumatic brain injury (mTBI) in mice. J. Mol. Neurosci. 54: 684- 697 (2014).

 

Katzav A., Menachem A., Maggio, N., Pollak, L., Pick C. G., and Chapman J. IgG accumulates in inhibitory hippocampal neurons of experimental antiphospholipid syndrome. J. Autoimm. 55: 86-

93 (2014).

 

Becker, M., Benromano, T., Shahar, A., Nevo, Z and Pick, C. G. Changes in the basal membrane of dorsal root ganglia Schwann cells explain the biphasic pattern of the peripheral neuropathy in streptozotocin Benromano, 

 

T., Defrin, R., Ahn, A. H., Zhao, J., Pick C. G and Levy, D. Closed-head injury promotes a selective trigeminal hyper-nociception: implication for the acute emergence of post traumatic headache. Eur. J. Pain 19: 621-628 (2015).

 

Defrin, R., Riabinin, M., Feingold, Y., Schreiber, S and Pick, C. G. Deficient pain modulation systems in chronic post traumatic headache. J. Neurotrauma 32: 28-37 (2015).

 

Shavit-Stein, E., Itsekson, Z., Aronovich, A., Reisner, Y., Pick C. G., Tanne, D., Chapman, J. and Maggio, N. Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke. Sci. Rep. 5: 7912 (2015).

 

Rubovitch, V., Baratz-Goldstein, R., Zilberstein, Y. and Pick, C. G. The involvement of the eIF2-alpha pathway in the neuroprotective effect of IGF-1 in mTBI. NeuroMolecular Med. 17:58-70 (2015).

 

Baratz, R., Tweedie, D., Rubovitch, V., Hoffer, B.J., Greig N. H. and Pick, C. G. Pathophysiological mechanisms of minimal traumatic brain injury (mTBI): TNF-a synthesis inhibitor as a potential neuroprotective therapy. J. Neuroinflamm. 12:45 (2015).

 

Yang, L-Y, Chu, Y-H, Tweedie, D., Yu, Q-S, Pick, C. G., Hoffer, B.J., Greig N. H. and Wang, J-Y. Post-trauma administration of the pifithrin-α oxygen analogue improves histological and functional outcomes after experimental traumatic brain injury. Exp. Neurol. 269:56-66 (2015).

 

Ben Shimon, M., Lens, M., Ikenberg, B., Becker, D., Shavit Stein, E., Chapman, J. Tanne, D., Pick, C. G. Blatt, I., Neufeld, M., Vlachos A. and Maggio, N. Thrombin regulation of synaptic transmission and plasticity: implications for health and disease. Front. Cell. Neurosci. 21; 9:151(2015).

 

Defrin, R., Amanzio, M., Violeta Dimova, V., Filipovic, S., David Finn, D., Gimenez-Llort, L., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J., Petrini, L., Pick, C. G., Pickering, G., de Tommaso, M., Invitto, S., Vase, L. and Kunz,M. Experimental pain processing in individuals with cognitive impairment: state of the art. Pain, 156:1396-1408 (2015).

 

Li Y., Bader, M., Pick C.G. and Greig, N.H. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice. J. Neurochem 135: 1203-1217 (2015). 

 

Baeta-Corral, R., Defrin, R., Pick C.G. and Lydia Giménez-Llort L. Nociception response is preserved in 3xTg-AD mice. Neurosci. Lett. 600:158-163 (2015).

 

Tweedie, D., Rachmany, L., Rubovitch, V., Li, Y., Holloway, H.W., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J., Pick C.G*. and Greig, N.H. * Blast traumatic brain injury induced cognitive deficits associated with hippocampal neurodegeneration and changes in gene expression are attenuated by treatment with the glucagon-like peptide-1 receptor agonist, exendin-4. Alzheimer Dement. 12: 34-48 (2016). *Equal contribution.

 

Schreiber, S., Bader, M., Rubovitch, V. and Pick, C.G. Interaction between methylphenidate, methadone and different antidepressants drugs in mice, and possible clinical implications. World J. Biol. Psychiatry (2016).

 

Leśniak, A., Sacharczuk, M., Chaim G. Pick, C.G. and Lipkowski, A.W. Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI). Neuropharmacol. 101:506-518 (2016).

 

Levy D, Edut S., Baratz-Goldstein R., Rubovitch, V., Defrin, R., Zhao J. and Pick C.G. Responses of dural mast cells in concussive and blast models of closed-head mild traumatic brain injury: implications for post-traumatic headache. Cephalalgia (2016).

 

Itsekson-Hayosh, Z. Shavit-Stein, E., Katzav, A.,Maggio, N., Harnof, S., Chapman, J. and Pick C.G. Minimal traumatic brain injury in mice – PAR-1 and thrombin related changes. J Neurotrauma (2016).

 

Deselms, H., Maggio, N., Rubovitch, V., Chapman, J. Schreiber, S., Tweedie, D., Kim, D.S, Greig, N.H Pick C.P. Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development. J Neurosci Meth. (2016). doi:10.1016/j.jneumeth.2016.02.002. 

 

Tweedie, D., Rachmany, L. Kim D.S., Rubovitch, V., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J., Pick C.G* and Greig, N.H. Mild traumatic brain injury-induced hippocampal gene expressions: the identification of target cellular processes for drug development. J Neurosci Meth. (2016). doi: 10.1016/j. jneumeth.2016.02.003. [Epub ahead of print]

 

Tweedie, D., Fukui, K., Li, Y., Barak, S., Tamargo, I., Rubovitch, V., Holloway, H.W., Hoffer, B.J. Becker, R.E., Pick, C.G. Greig, N.H. Cognitive impairments induced by concussive mild traumatic brain injury in mouse are ameliorated by treatment with phenserine Sackler Faculty of Medicine Research 2016 176 Nervous System and Behavorial Disorders via multiple non-cholinergic mechanisms. PLoS One. (2016). 11(6):e0156493.

 

Benromano, T., Pick, C.G. Merik, J. and Defrin, R. Objective and subjective indicators of pain among individuals with cerebral palsy and intellectual disability. Pain Med (In press).

 

Baratz-Goldstein, R., Deselms, H., Haim, L.,Khomsky, L., Hoffer, B.J., Atlas, D. and Pick, C.G. Thioredoxin-mimetic-peptides protect cognitive function after mild traumatic brain injury (mTBI). PLoS One 2016;11(6):e0157064.

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