Prof. Chaim Pick

Emeritus in Anatomy and Anthropology
Medicine Dean & Assoc. Deans
אנטומיה ואנתרופולוגיה אמריטוס
Prof. Chaim Pick
Phone: 03-6409247
Fax: 03-6408287
Office: Sackler School of Medicine, 633


Professor, Department of Anatomy & Anthropology, Sackler Faculty of Medicine

Director, the Sylvan Adams Sports Institute        


Brain Injuries: Cognitive, Behavioral and Cellular Outcome

My group has a long history in Traumatic Brain Injury research, not only in characterizing behavioral and biochemical sequelae of blunt head trauma, but also in developing preclinical models of mTBI of translational relevance to support the development of new treatment strategies and drugs. In order to look for answers regarding the blast induced traumatic brain injury, we have developed a blast injury model for mice that resembles, as much as possible, the conditions on the battlefield or at a terror-attack site. As such, the outcomes of the “real-life-like” exposure to the blast in our model may vary from severe to mild brain injury under controlled conditions for each mouse.

Physical activity for the improvement of quality of life

Over the years, my research group ha been involved in thorough studies of physical activity and its effects on brain- and medical conditions in special human populations (e.g., persons with cognitive disability; hospitalized psychiatric patients), the beneficial effects of physical activity on recovery from brain damage, and in animal models (e.g., minimal traumatic brain injured mice; reducing tumor proliferation rate in mice). 

Most recently we are studying the effects of aerobic training on the brain following traumatic brain injury and the exact best timing to start the training. In addition, we are looking at the effects of various types of nurtition (including catogenic diet) alone or in combination with physical activity, on recovery from brain trauma.  


Recent Publications

1.              Pick C.G. and Yanai, J., Eight-arm maze for mice. Int. J. Neuroscience 21:63-66 (1983).  dot:10.3109/00207458308986121

2.              Pick C.G. and Yanai, J., Long-term reduction in spontaneous alterations after early exposure to phenobarbital. Int. J. Dev. Neuroscience 2:223-228 (1984).      dot:10.1016/0736-5748(84)90016-9.

3.              Pick C.G. and Yanai, J., Long-term reduction in eight-arm maze performance after early exposure to phenobarbital. Int. J. Dev. Neuroscience 3:223-227 (1985).                 dot:10.1016/0736-5748(85)90027-9.

4.              Lieblich, I., Baum, M.J., Diamond, P., Goldblom, N., Iser, C. and Pick, C.G. Inhibition of mating by naloxone or morphine in recently castrated, but not intact male rats. Pharmacology Biochemistry Behavior 22:361-364 (1985).       dot:10.1016/0091-3057(85)90032-2

5.              Yanai, J., Iser, C., Kleinberger N., and Pick, C.G. Mechanism of the phenobarbital effect on CNS development: A potential model for intervention. In: D. Tamir, TB. Breazelton and A. Russel (Eds.) Stimulation and Intervention in Infant Development. pp. 405-412, Freund/London (1986).

6.              Yanai, J., Pick, C.G., Weinstein, D. and McRae-Degueurce, A. The use of brain tissue transplantation in neuroteratological studies. NeuroToxicology 7:141-146 (1986).

7.              Yanai, J., Pick, C.G. and Iser-Strenger, C. Chronic treatment with haloperidol affect the response of the brain to pentobarbital. Neuropharmacology 25:943-945 (1986). doi:10.1016/0028-3908(86)90026-2

8.              Yanai, J., Pick C.G. and McRae-Degueurce, A. Reversal of phenobarbital- induced behavioral birth defects in mice by brain tissue transplantation. In: Schenker J. G. and D. Weinstein. (Eds.) The Intrauterine Life- Management and Therapy. pp. 389-393, Elsevier/Amsterdam (1986).

9.              Yanai, J. and Pick, C.G. Studies on noradrenergic alternations in relation to early phenobarbital-induced behavioral changes. Int. J. Dev. Neuroscience 5:337-344 (1987).  dot:10.1016/0736-5748(87)90009-8

10.       Pick, C.G., Statter, M., Ben-Shachar, D., Youdim, M.B.H. and Yanai, J. Normal zinc and iron concentrations in mice after early exposure to phenobarbital. Int. J. Dev. Neuroscience 5:391-398 (1987).   doi:10.1016/0736-5748(87)90016-5

11.       Yanai, J., Z. Greenfeld, U. Laxer, Pick, C.G. Trombka, D. and D. Weinstein. CNS changes after early barbiturate exposure: mechanisms and reversal. In: T. Fujii and P.M. Adams. (eds). Functional Teratogenesis, pp. 121-130, Tokyo-University Press/Tokyo (1987).

12.       Yanai, J., Z. Greenfeld, Pick C.G. and D. Trombka. Cholinergic mechanisms of behavioral deficits after prenatal exposure to phenobarbital. In: S. Cohen and M. Sokolovsky. (eds). International Symposium on Muscarinic Cholinergic Mechanisms. pp. 374-378, Freund/ London (1987).

13.       Yanai, J. and Pick, C.G. Neuron transplantation reverses phenobarbital- induced behavioral birth defects in mice. Int. J. Dev. Neuroscience 6:409-416 (1988).      doi:10.1016/0736-5748(88)90046-9

14.       Kaspi, A., Yanai, J., Pick, C.G. and Mann, G. Entrapment of the distal suprascapular nerve: an anatomical study. International Orthopaedics 12:273- 275 (1988).

15.       Yanai, J., A. Bergman, M. Keltz and Pick C.G. Mechanisms of sensitivity and tolerance to and physical dependence on ethanol and barbiturates. In: J. Yanai, R. Bauml, P. Eldar and J. M. Rosenfeld. (Eds.) Alcohol Dependence, The Family and The Community. pp.143-158, Freund/London (1988).

16.       Pick, C.G. and Yanai, J. Studies into the mechanisms of strain differences in hippocampal-related behaviors. Behavior Genetics 19:315-325 (1989).

17.       Yanai, J, F. Fares, M. Gavish, Z. Greenfeld, Pick, C. G., Rogel-Fuchs Y. and D. Trombka. Two approaches for the reversal phenobarbital- induced behavioral birth defects. In: F. Gage, A. Privat and Y. Christen. (Eds.) Neuronal Grafting and Alzheimer's Disease. pp.165-176, Springer- Verlag/Berlin Heidelberg (1989).

18.       Yanai, J., Laxer, U., Pick, C.G. and Trombka, D. Dopaminergic denervation reverses behavioral deficits induced by prenatal exposure to phenobarbital. Dev. Brain Research 48:255-261 (1989).  doi:10.1016/0165-3806(89)90080-1

19.       Yanai, J., Fares, F., Gavish, M., Greenfeld, Z., Katz, Y., Marcovici, B.G., Pick, C.G., Rogel-Fuchs, Y. and Weizman, A. Neural and behavioral alterations after early exposure to phenobarbital. NeuroToxicology 10:543-554 (1989).

20.       Weizman, A., Fares, F., Pick, C.G., Yanai, J. and Gavish, M. Chronic phenobarbital administration affects GABA and benzodiazepine receptors in the brain and peripheral. Eur. J. Pharmacology 169:235-240 (1989). doi:10.1016/0014-2999(89)90020-4

21.       Fares, F., Weizman, A., Pick, C.G., Yanai, J. and Gavish, M. Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors. Brain Research 506:115-119 (1990).  doi:10.1016/0006-8993(90)91206-V

22.       Paul, D., Pick, C. G. and Pasternak G. W. Dissociation of kappa1 and kappa3 analgesia: Pharmacological characterization of naloxone benzoylhydrazone. In: New leads in opioid research (Eds.) Van ree, J. M., Mulder, A. H., Wiegant, V.M. and van Wimersma Greidanus, T.B. pp. 56-57 Excerta Medica/ Amsterdam. (1990).

23.       Yanai, J., Pick C.G. Y. Rogel-Fuchs, and E.A., Zahalka. Alterations in septohippocampal cholinergic receptors and related behavior after prenatal exposure to nicotine. In: K. Thurau and F. Adlkofer (Eds.) Effects of Nicotine on Biological Systems, Advances in Pharmacological Sciences. Pp. 401-406, Birkhauser Verlag/Hamburg. (1991).

24.       Paul, D., Levison, J.A., Howard, D.H., Pick, C.G., Hahn, E.F. and Pasternak, G.W. Naloxone Benzoylhydrazone (NalBzoH) Analgesia. J. Pharmacology and Experimental Therapeutics 255:769-774 (1990).

25.       Paul, D., Pick, C.G., Tive, L.A. and Pasternak, G.W. Pharmacological characterization of nalorphine, a kappa3 analgesic.  J. Pharmacology and Experimental Therapeutics 257:1-7 (1991).

26.       Pick, C.G., Cheng, J. Paul, D. and Pasternak G.W. Genetic influences in opioid analgesia sensitivity in mice. Brain Research 566:295-298 (1991). doi:10.1016/0006-8993(91)91712-A

27.       Pick, C.G., Paul, D. and Pasternak G.W. Comparison of Naloxonazine and betta-funaltrexamine Antagonism of mu1 and mu2 Analgesia. Life Sciences 48:2005-2011 (1991). doi:10.1016/0024-3205(91)90155-5

28.       Pick, C.G., Paul, D. Eison, M.S. and Pasternak G.W. Potentiation of opioid analgesia by the antidepressant Nefazodone. Eur. J. Pharmacology 211:375-381 (1992).  doi:10.1016/0014-2999(92)90395-K

29.       Froimowitz, M. Pick, C.G., and Pasternak G.W. Phenylmorphins and analogues: Opioid receptor subtype selectivity and effect of conformation on activity. J. Med. Chem. 35:1521-1525 (1992).   dot:10.1021/jm00087a004

30.       Tive, L.A., Pick, C.G., Paul, D., Roques, B.P., Gacel, G.A. and Pasternak G.W. Analgesia potency of Trimu-5: a mixed mu-2 agonist/mu-1 antagonist. Eur. J. Pharmacology 216:249-255 (1992).   doi:10.1016/0014-2999(92)90367-D

31.       Pick, C.G., Roques, B.P., Gacel, G.A. and Pasternak G.W. Supraspinal mu-2 receptors mediate spinal/ supraspinal morphine synergy. Eur. J. Pharmacology 220:275-277 (1992).   dot:10.1016/0014-2999(92)90761-R

32.       Tive, L.A., Ginsberg, K., Pick, C.G., and Pasternak G.W. Kappa3 receptors and levarphanol- induced analgesia. Neuropharmacology 31:851-856 (1992). doi:10.1016/0028-3908(92)90121-5

33.       Pick, C.G., Paul, D. and Pasternak G.W. Nalbuphine, a mixed kappa1 and kappa3 analgesic in mice. J. Pharmacology and Experimental Therapeutics 262:1044-1050 (1992).

34.       Kolesnikov, Y.A., Pick, C.G. and Pasternak, G.W. NG-Nitro-L-arginine prevents morphine tolerance. Eur. J. Pharmacology 221:399-400 (1992). dot:10.1016/0014-2999(92)90732-J

35.       Yanai, J., Pick C.G., Y. Rogel-Fuchs, and E.A., Zahalka. Alterations in hippocampal cholinergic receptors and hippocampal behaviors after early exposure to nicotine. Brain Research Bulletin 29:363-368 (1992). doi:10.1016/0361-9230(92)90069-A

36.       Laviola, G., Pick, C.G., Yanai, J. and E. Alleva. Eight-arm maze performance, neophobia and hippocampal cholinergic alterations after prenatal oxazepam in mice. Brain Research Bulletin 29:609-616 (1992). doi:10.1016/0361-9230(92)90130-P

37.       Yanai, J., Y. Avraham, S. Levi, J., Maslaton, Pick C.G., Y. Rogel- 3 Fuchs, and E.A., Zahalka. Alterations in septohippocampal cholinergic innervations and related behaviors after early exposure to heroine and phencyclidine. Dev. Brain Research 69:207-214 (1992).  dot:10.1016/0165-3806(92)90161-O

38.       Yanai, J. Y. Rogel-Fuchs Pick, C.G., T. Slotkin, E.A., Zahalka and M.E. Newman. Septohippocampal Cholinergic changes after destruction of the A10-septal Dopaminergic Pathways. Neuropharmacology 32:113-117 (1993).dot:10.1016/0028-3908(93)90090-P

39.       Pick, C. G., Nejat, R. J. and Pasternak G.W. Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains. J. Pharmacology and Experimental Therapeutics 265:166-171 (1993).

40.       Kolesnikov, Y.A., Pick, C.G., Ciszewska, G. and Pasternak, G.W. Blockade of tolerance to morphine but not kappa opioids by nitric oxide synthesis inhibitor.    Proc. Natl. Acad. Sci. USA 90:5162-5166 (1993).

41.       Pick, C.G., A. Weizman, F. Fares, M. Gavish, B. Kanner and J. Yanai. Hippocampal GABA and benzodiazepine receptors after early phenobarbital exposure. Dev. Brain Research 74:111-116 (1993).dot:10.1016/0165-3806(93)90089-S

42.       Pick, C.G., M. Cooperman, D. Trombka, Y, Rogel-Fuchs and J. Yanai. Hippocampal cholinergic alternation and related behavioral deficits after early exposure to ethanol. Int. J. Devl. Neuroscience 11:379-385 (1993). dot:10.1016/0736-5748(93)90009-3

43.       Katz, Y., Amiri, Z., Pick, C. G., Weizman, R., Yanai, J., and Gavish, M.   Effect of chronic prenatal, neonatal and adult exposure to barbiturates on mitochondrial benzodiazepine receptors in mouse testis.  Biochemical Pharmacology 47: 910-913 (1994).   dot:10.1016/0006-2952(94)90492-8

44.       Katz, Y., Weizman, A., Pick, C. G., Pasternak, G.W., Liu, L., Fonia, O. and Gavish, M. Interactions between laudanosine, GABA and brain opioid subtype receptors: implication for laudanosine seizure activity. Brain Research 646: 235-241 (1994).   dot:10.1016/0006-8993(94)90084-1

45.       Pick, C. G. Antinociceptive interaction between alprazolam and opioids: Genetic Differerences.  Regulatory Peptides 54:223-224 (1994). dot:10.1016/0167-0115(94)90471-5

46.       Shye, S., J. Yanai, and Pick C.G. Directional consistency: Determinant of learned maze performance of five mice strains.  Behavioral Processes 32: 117-132 (1994). dot:10.1016/0376-6357(94)90070-1

47.       Yanai, J., Shaanani, R. and Pick, C.G. Altered brain sensitivity to ethanol in mice after MPTP treatment. Alcohol 12: 127-130 (1995). dot:10.1016/0741-8329(94)00066-2

48.       Yanai, J. and Pick C.G. Neuron transplantation into mice hippocampus alters  sensitivity to barbital nacrosis. Brain Research Bulletin 38: 93-98 (1995). dot:10.1016/0361-9230(95)00077-R

49.       Schreiber, S. and. Pick, C.G. Fluoxetine for blephrospasm: Interaction of serotonin and dopamine. J. Nervous and Mental Disease 183: 719-721 (1995). 

50.       Schreiber, S. Backer, M.M. and Pick, C.G. The opioid properties of tetracyclic antidepressant.  Analgesia 1: 707-710 (1995).

51.       Pick, C. G., Strain differences in mice antinociception: relationship between alprazolam and opioid receptor subtype. Eur. Neuropsychopharmacology 6: 201-206 (1996).   dot:10.1016/S0924-977X(96)00031-4

52.       Pick, C.G., Peter, Y., Terkel, J., Gavish, M. and   Weizman, R.  The effect of the neuroactive steroid a-THDOC on staircase test behavior in mice. Psychopharmacology 128: 61-66 (1996).

53.       Schreiber, S., Backer, M.M., Yanai, J. and Pick C.G. The antinociceptive effect of fluvoxamine.  Eur. Neuropsychopharmacology 6: 281-284 (1996). dot:10.1016/S0924-977X(96)00031-4

54.       Schreiber, S., MM. Backer, R., Weizman and Pick C.G. The antinocicicptive effects of fluoxetine.  The Pain Clinic 9:349-356 (1996).

55.       Pick, C. G. Antinociceptive interaction between alprazolam and opioids.  Brain Research Bulletin 42: 239-243 (1997).   dot:10.1016/S0361-9230(96)00265-1

56.       Pick, C.G., Peter, Y., Schreiber, S. Weizman, R. Pharmacological characterization of buprenorphine, a mixed agonist - antagonist with kappa3 analgesia. Brain Research 744: 41-46 (1997).    dot:10.1016/S0006-8993(96)01069-4

57.       Schreiber, S., Backer, M.M., Weizman R. and Pick C.G.   Augmentation of  opioid induced antinociception by the atypical antipsychotic drug risperidone in mice. Neuroscience Letters 228: 25-28 (1997).  dot:10.1016/S0304-3940(97)00345-5

58.       Schreiber, S. and Pick, C.G. Paroxetine for secondary stuttering: further interaction of serotonin and dopamine. J. of Nervous and Mental Disease 185: 465- 467  (1997).

59.       Pick, C.G., Peter, Y., Paz, L., Schreiber, S., Gavish, M. and   Weizman, R. Effect of the pregnane-related GABA active steroid alphaxalone on mice performance in the staircase test. Brain Research 765: 129-134 (1997). dot:10.1016/S0006-8993(96)01069-4

60.       Backer, M.M., Schreiber, S. and Pick C. G. Interactions between different antidepressant and morphine alter gastrointestinal transit in mice. Life Sciences 61: PL109- PL 113 (1997).    dot:10.1016/S0024-3205(97)00595-X

61.       Weizman, R. Pankova, I.A., Schreiber, S. and Pick, C. G.  Flunarizine analgesia is mediated by mu opioid receptors. Physiology & Behavior 62: 1193- 1195 (1997).dot:10.1016/S0031-9384(97)00344-2

62.       Schreiber, S., Getslev, V., Weizman, A and Pick C. G. The antinociceptive effect of moclobemide is mice is mediated by noradrenergic pathways. Neuroscience Letters 253: 183-186 (1998).  dot:10.1016/S0304-3940(98)00638-7

63.       Schreiber, S., M.M. Backer, J. P. Kaufman and Pick C. G. Interaction between the tetracyclic antidepressant Mianserin HCL and opioid receptors. Eur. Neuropsychopharmacology 8: 297-302 (1998).dot:10.1016/S0924-977X(97)00088-6

64.       Schreiber, S. Klag, E., Gross, Y., Segman, R. H and Pick C. G.  Beneficial effect of risperidone on sleep disturbance and psychosis following traumatic brain injury. Int. Clinical Psychopharmacology 13: 273-275 (1998). dot:10.1016/S0304-3940(98)00638-7

65.       Weizman, R., Getslev, V., Pankova I. A., Schreiber, S, and Pick C. G. Pharmacological interaction of the calcium channel blockers verapamil and flunarizine with the opioid system. Brain Research 818: 187-195 (1999). dot:10.1016/S0006-8993(98)01175-5

66.       Schreiber, S., Gatslev, V., Backer, MM., Weizman, R., and Pick C. G. The atypical neuroleptices clozapine and olanzapine differ regarding their antinociceptive mechanisms and potency. Pharmacology, Biochemistry and Behavior 64:75-80 (1999).  dot:10.1016/S0091-3057(99)00107-0

67.       Schreiber, S., Backer, M. M. and Pick C. G. The antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanisms. Neuroscience Letters 273: 85-88 (1999).    dot:10.1016/S0304-3940(99)00627-8

68.       Weizman, R., Paz, L., Backer, MM., Amiri, Z., Modai, I. and Pick C. G. Mouse strains differ in their sensitivity to alprazolam effect in the staircase test. Brain Research 839: 58-65 (1999).  dot:10.1016/S0091-3057(01)00450-6

69.       Schreiber, S. Backer, M. M. Herman, I. Shamir, D. Boniel, T. and Pick C. G. The antinociceptive  effect of trazodone in mice is mediated through both -opioid and serotoninergic mechanisms. Behavioral Brain Research 114: 51-56 (2000). dot:10.1016/S0166-4328(00)00185-6

70.       Weizman, R., Paz, L., Peter, Y and Pick C. G. Mice performance on the staircase test following acute ethanol administration. Pharmacology, Biochemistry and Behavior 68: 491-495 (2001).  dot:10.1016/S0091-3057(01)00450-6

71.       Weizman, R., Paz, L., Peter, Y., Toren P. and Pick C.G. Behavioral effects of agents active at the gamma- amino butyric acid receptor complex in the staircase paradigm. Brain Research 901:137-142 (2001). dot:10.1016/S0006-8993(01)02331-9

72.       Katzav, A, Pick, C. G., Korczyn, A.D., Oest, E., Blank, M. Shoenfeld, Y. and Chapman, J.  Hyperactivity in a mouse model of the antiphospholipid syndrome. Lupus 10: 496-499, (2001).   dot:10.1191/096120301678416060

73.       Schreiber, S., S. Vinokur, V, Shavelzon, Pick, C. G., E. Zahavi and  Y. Shir. A randomized trial of fluoxetine versus amitriptyline in musculo-skeletal pain.  Isr. J. Psychiatry 38: 88-94 (2001).

74.       Schreiber, S., Bleich, A. Pick C. G. Venlafaxine and mirtazapine: Different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects - a possible opioid involvement in severe depression?  J.  Molecular Neuroscience 18:143- 147, (2002).

75.       Schreiber, S., Rigai, T., Katz, Y. and Pick C. G. The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms. Brain Research Bulletin 58: 601-605 (2002). doi:10.1016/S0361-9230(02)00825-0

76.       Shrot, S., Katzav, A., Korczyn, AD. Litvinjuk, Y., Hershenson, R., Pick, C. G., Blank, M., Zaech, J., Shoenfeld, Y., Sirota, P. and Chapman, J. Behavioral and cognitive deficits occur after prolonged exposure of mice to antiphospholipis antibodies. Lupus 11: 736-43 (2002).  doi:10.1191/0961203302lu255oa

77.       Schreiber, S. Backer M.M, Herman, I. Shamir, D. Rigai, T. Bar-Hamburger, R and Pick C. G. Mianserin and trazodone significantly attenuate the intensity of opioid withdrawal symptoms in mice. Addiction Biology 8: 107-114 (2003).  doi:10.1080/1355621031000069954  

78.       Pan, W., Kastin, A. J. Rigai, T., McLay, R. and Pick C. G.  Increased hippocampal uptake of tumor necrosis factor alpha and behavioral changes in mice. Exp. Brain Research 149: 195-199  (2003).  doi:10.1007/s00221-002-1355-7

79.       Zohar, O. Schreiber, S. Getslev, V., Schwartz, JP. Mullins, PG. and Pick C. G. Closed-head minimal traumatic brain injury produces long term cognitive deficits in mice. Neuroscience 118: 949-955 (2003).  doi:10.1016/S0306-4522(03)00048-4

80.       Shoenfeld, Y., Nahum, M.D., Korczyn, A.D., Dano, M., Rabinowitz, R. Beilin, A.O., Pick, C. G., Leider-Trejo, L., Kalashnikova, L., Blank, M. and Chapman, J.  Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer. Lupus 12: 436-442 (2003).  doi:10.1191/0961203303lu409oa

81.       Gazit, V., Ben- Abraham, R. Pick C. G. and Y. Katz. b-Phenylpyruvate induces long-term neurobehavioral damage and brain necrosis in neonatal mice. Behavioral Brain Research 143: 1-5 (2003).  doi:10.1016/S0166-4328(03)00075-5

82.       Weizman, T., Pick C. G. Backer, M.M., Rigai, T. and Schreiber, S. The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms. Eur. J. Pharmacology 478: 150-159 (2003). doi:10.1016/j.ejphar.2003.08.049

83.       Gazit, V., Ben-Abraham, R., Pick C. G. Ben-Shlomo, I. And  Katz, Y. long-term neurobehavioral and histological damage in brain of mice induced by L-cysteine. Pharmacology, Biochemistry and Behavior 75: 795-799 (2003). doi:10.1016/S0091-3057(03)00147-3

84.       Defrin, R., Pick C. G. Peretz, H. and Carmeli. E. A quantitative somatosensory testing of pain threshold in individuals with mental retardation. Pain 108:58-66 (2004).    doi:10.1016/j.pain.2003.12.003

85.       Kaidanovich-Beilin, O., Milman, A., Weizman, A., Pick, C. G. and Eldar-Finkelman, H. Rapid antidepressive-like activity of specific GSK-3 inhibitor and its effect on beta-catenin in the mouse hippocampus. Biological Psychiatry 55:781-784 (2004).   doi:10.1016/j.biopsych.2004.01.008

86.       Alcalay, R. N., Giladi, Pick, C. G, and I. Gozes. Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze. Neuroscience Letters 361: 128-131(2004). doi:10.1016/j.neulet.2003.12.005

87.       Benaroya–Milshtein, N., Hollander N., Apter A., Wilf A., Kukulansky, T. Raz, N., Yaniv, I. and Pick C. G. Environmental enrichment in mice decreases anxiety, attenuates stress response and enhances natural killer cell activity. Eur. J. Neuroscience 20: 1341-1347 (2004). doi:10.1111/j.1460-9568.2004.03587.x

88.       Defrin, R. Carmeli E. and Pick, C. G. Behavioral indices of pain and pain threshold measurement in individuals with mental retardation- Letter to the Editor. Pain 110:767-769 (2004).  doi:10.1016/j.pain.2004.04.041

89.       Barkai, G., Goshen, E., Zwas, T.Z., Dolberg, O.T., Pick C. G. Bonne, O. and Schreiber, S. Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after mTBI not otherwise discernible. Psychiatry Res. Neuroimaging 132: 279-283 (2005).   doi:10.1016/j.pscychresns.2004.09.004

90.       Pan. W., Kastin, A.J. and Pick C. G. The Staircase Test in mice after Spinal cord injury. International Journal NN 1: 32-37 (2004).

91.       Zohar O., Pick C. G., Cavallaro, S., Chapman, J., Katzav, A, Milman, A, and Alkon D.L. Age dependent differential expression of BACE splice variants in brain regions of tg2576 transgenic mice. Neurobiology of Aging 26:1167-1175 (2005).   doi:10.1016/j.neurobiolaging.2004.10.005

92.       Pick C. G. Chernes, Y., Rigai, T., Rice K.C. and Schreiber, S. The antinociceptive effect of zolpidem and zopiclone in mice.  Pharmacology Biochemistry and Behavior 81:417-423 (2005).  doi:10.1016/j.pbb.2005.02.013

93.       Milman A., Rosenberg, A., Weizman R. and Pick C. G. Mild traumatic brain injury induces persistent cognitive deficits and behavioral disturbance in mice.  J.  Neurotrauma 22: 1003-1010 (2005).   doi:10.1089/neu.2005.22.1003.

94.       Leitner, Y., Heldman D., Harel S. and Pick C. G. Deficits in spatial orientation of children with intrauterine growth retardation. Brain Research Bulletin 67:13-18 (2005). doi:10.1016/j.brainresbull.2005.04.017

95.       Defrin, R., Ben Benyamin, S., Aldubi, D., and Pick C. G. Conservative  correction of leg length discrepancy of 10mm or less for the relief  of chronic low back pain. Archives of Physical Medicine and Rehabilitation 86:2075-2080 (2005). doi:10.1016/j.apmr.2005.06.012

96.       Herman, I., D. Shamir, R. Bar-Hamburger, Pick, C. G. and Schreiber, S.  The effect of mianserin add- on, on the intensity of opioid withdrawal symptoms during detoxification program – A randomized double blind, placebo controlled study. Addictive Behaviors 30:1154-1167 (2005). doi:10.1016/j.addbeh.2004.12.004

97.       Zohar, O. Getslev, V. Miller, A.L. Schreiber, S. and Pick C. G. Morphine protects for head trauma induced cognitive deficits in mice. Neuroscience Letters 394:239-242 (2006). doi:10.1016/j.neulet.2005.10.099

98.       Katzav, A. Litvinjuk, Y., Pick, C. G., Blank, M., Shoenfeld, Y., Sirota, P. and Chapman, J.  Genetic and immunological factors interact in a mouse model of CNS antiphospholipid syndrome. Behavioral Brain Research 169: 289-293 (2006).  doi:10.1016/j.bbr.2006.01.015

99.       Schreiber, S. and Pick C. G. From selective to highly- selective SSRIs: A     comparison of the antinociceptive properties of fluoxetine, fluvoxamine, citalopram and escitalopram. Eur. Neuropsychopharmacology 16: 464-468 (2006).  doi:10.1016/j.euroneuro.2005.11.013

100.    Defrin R., Lotan, M, and Pick C. G. The evaluation of acute pain in individuals with cognitive impairment: A differential effect of the level of impairment. Pain 124: 312-320 (2006).   doi:10.1016/j.pain.2006.04.031

101.    Milman A., Weizman R. Rigai, T, Rice K.C. and Pick C. G. Behavioral effects of opioids subtypes compared with benzodiazepines in the staircase paradigm. Behavioral Brain Research 170: 141-147 (2006).  doi:10.1016/j.bbr.2006.02.017

102.    Tashlykov V., Katz, Y. Gazit V.  Zhoar O. Schreiber S. and Pick C. G. Apoptotic changes in the cortex and hippocampus following minimal brain trauma in mice. Brain Research 1130: 197-205 (2007).  doi:10.1016/j.brainres.2006.10.032

103.    Tselnicker, I., Keren, O., Hefez, A., Pick, C. G. and Sarne S. A single low dose of tetrahydrocannabinol induces long-lasting cognitive deficits. Neuroscience letters 411:108-111 (2007)   doi:10.1016/j.neulet.2006.10.033

104.    Katzav A., Solodeev, I., Brodsky, O., Chapman J., Pick C. G., Blank M., Zhang, W., Reichlin, M. and Shoenfeld Y. Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis and Rheumatism 56:938-948 (2007). doi:10.1002/art.22419

105.    Tweedie D., Milman, A., Holloway, H.W., Li, Y., Harvey, B.K., Shen, P. Pistell, H., Lahiri, D.K., Hoffer, B.J. Wang, Y., Pick* C. G. and Greig* N.H. Apoptotic and behavioral sequelae of mild brain trauma in mice. Journal of Neuroscience Research 85: 805-815 (2007). *Equal contribution  doi:10.1002/jnr.21160

106.    Benaroya-Milshtein N., Apter A., Yaniv I., Kukulansky T., Raz, N., Haberman Y., Halpert H., Pick* C. G. Hollander* N. Environmental enrichment augments the efficacy of idiotype vaccination for beta-cell lymphoma. Journal of Immunotherapy 30:517-22 (2007). *Equal contribution doi:10.1097/CJI.0b013e31804efc5e

107.    Shapira, M. Licht, A. Milman, A. Pick, C. G. Shohami, E. and Eldar-Finkelman, H.  Role of glycogen synthase kinase-3β in early depressive behavior induced by mild traumatic brain injury. Mol. Cell. Neuroscience 34: 571-577 (2007). doi:10.1016/j.mcn.2006.12.006

108.    Schreiber, S. Barkai, G., Gur-Hartman, T. Peles, E., Naveh, T. Dolberg, O.T. and Pick C. G. Long-lasting sleep patterns of adult patients with minor traumatic brain injury (mTBI) and non-mTBI subjects. Sleep Medicine 9: 481- 487 (2008). doi:10.1016/j.sleep.2007.04.014

109.    Milman A., Zohar O., Maayan R., Weizman, R., and Pick C. G. DHEAS repeated treatment improves cognitive and behavioral deficits after mild TBI. Eur. Neuropsychopharmacology 18:181-187 (2008).                doi:10.1016/j.euroneuro.2007.05.007

110.    Tanne, D., Katzav A., Beilin, O., Grigoriadis, N.C., Blank, M., Pick, C. G., von Landenberg, P., Shoenfeld, Y, and J Chapman.  Interaction of inflammation, thrombosis, aspirin and enoxaparin in CNS experimental antiphspholipid syndrome. Neurobiology of Disease 30:56-64 (2008). doi:10.1016/j.nbd.2007.12.004.

111.    Zohar, O., Reiter, Y., Bennink, JR, Lev, A, Cavallaro, S., Paratore, S.,  Pick, C. G., Brooker G., and Yewdell J.W. Cutting Edge; MHC class I-Ly49 interaction regulates neuronal function. J. of  Immunology 180:6447-6451 (2008).  doi:10.4049/​jimmunol.180.10.6447

112.    Dror, R. Malinger, G. Ben-Sira, L. Lev, D. Pick, C. G. and Lerman-Sagie, T. Enlargement of the fetal posterior fossa- what is the significance? Harefuah (Hebrew)147:11873-878 (2008).

113.    Tashlykov, V., Katz, Y., Volkov A., Gazit, V., Schreiber, S.,  Zohar, O. and Pick, C. G.  Minimal traumatic brain injury induce apoptotic cell death in mice. Journal of Molecular Neuroscience 37:16-24 (2009).  doi:10.1007/s12031-008-9094-2.

114.    Lotan M, Ljunggren AE, Johnsen TB, Defrin R, Pick C. G., Strand LI. A modified version of the Non-Communicating Children Pain Checklist-Revised, adapted to adults with intellectual and developmental disabilities: Sensitivity to pain and internal consistency. The Journal of pain 10:398-407 (2009). doi:10.1016/j.jpain.2008.09.006

115.    Israelson, C. Wang, Y. Kylberg, A. Pick, C. G.,  Hoffer, B.J and Ebendel, T. Closed head injury in a mouse model results in molecular changes indicating inflammatory responses. J.  Neurotrauma 26: 1307-1314 (2009).                     doi:10.1089/neu.2008.0676.

116.    Rubovitch, V., Pick C. G. and Sarne, Y. Is withdrawal-hyperalgesia in morphine-dependent mice a direct effect of a low concentration of the residual drug. Addiction Biology 14:438 - 446 (2009).  doi:10.1111/j.1369-1600.2009.00164.x.

117.    Schreiber, S., Frishtick, R., Volis, I., Rubovitch, V., Pick, C. G*. and Weizman, R*. The antinociceptive properties of reboxetine in acute pain. Eur. Neuropsychopharmacology, 19:735- 739 (2009). *Equal contribution doi:10.1016/j.euroneuro.2009.06.004

118.    Dror, R. Malinger, G. Ben-Sira, L. Lev, D. Pick, C. G. and Lerman-Sagie, T. Developmental outcome of children with enlargement of the cisterna magna identified in utero. Journal of Child Neurology 24: 1486-1492 (2009).  doi:10.1177/0883073808331358.

119.    Schreiber, S.  and Pick, C. G.  Physical activity, contact sports and quality of sleep: the good, the bad and the (possibly) ugly. Sleep Medicine 10:13-14 (2009). doi:10.1016/j.sleep.2008.02.003

120.    Rubovitch V, Edut S, Sarfstein R, Werner H, Pick, C. G. The intricate involvement of the insulin-like growth factor receptor signaling in mild traumatic brain injury in mice. Neurobiology of Disease 38:299-303 (2010). doi:10.1016/j.nbd.2010.01.021

121.    Baratz, R., Rubovitch, V., Frenk, H. and Pick, C. G. The Influence of Alcohol on behavioral recovery following mTBI in mice. J Neurotrauma 27:555-63 (2010).  doi:10.1089/neu.2009.0891.

122.    Defrin R, Gruener, H, Schreiber, S and Pick C. G., Quantitative somatosensory testing of subjects with chronic post traumatic headache: implications on its mechanism. Eur J Pain 14:924-31 (2010).   doi:10.1016/j.ejpain.2010.03.004.

123.    Katzav, A., Faust-Socher, A., Kvapil, F., Michaelson. D.M., Blank, M., Pick C. G., Shoenfeld, Y., Korczyn, A. and Chapman, J. Antiphospholipid syndrome induction exacerbates a transgenic alzheimer disease model on a female background. Neurobiology of Ageing 32: 272- 279 (2011).  doi:10.1016/j.neurobiolaging.2009.02.007

124.    Zohar, O., Lavy, R., Zi, X., Nelson, T.J., Hongpaisan, J., Pick, C. G. and Alkon, D.L. PKC activator therapeutic for mild traumatic brain injury in mice. Neurobiology of Disease 41: 329-337 (2011). doi:10.1016/j.nbd.2010.10.001.

125.    Shen, H, Harvey, B.K, Chiang, Y-H, Pick C. G.*, and Wang, Y.* Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice. Brain Research 1368: 248- 253 (2011). *Equal contribution. doi:10.1016/j.brainres.2010.10.014.

126.    Benaroya-Milshtein, N., Hollander, N., Apter, A., Yaniv, I., and Pick, C. G. Stress conditioning in mice: alterations in immunity and tumor growth. Stress 14:301-311(2011).     doi:10.3109/10253890.2010.545845

127.    Edut S., Rubovitch, V., Schreiber, S., and Pick C. G. The intriguing effects of ecstasy (MDMA) on cognitive function in mice subjected to a minimal traumatic brain injury (mTBI). Psychopharmacology 214: 877-889 (2011). doi:10.1007/s00213-010-2098-y.

128.    Rubovitch, V., Schchar, A., Werner H, and Pick C. G. Does IGF-1 administration after a mild traumatic brain injury in mice activate the adaptive arm of ER stress. Neurochemistry International 58: 443-446 (2011).     doi:10.1016/j.neuint.2011.01.009.

129.    Zohar, O., Rubovitch, V., Milman, A., Schreiber, S., and Pick C. G.   Behavioral Consequences of Minimal Traumatic Brain Injury in Mice. Acta  Neurobiologiae Experimentalis 71:36-45 (2011).

130.    Defrin R, Gruener, H, Schreiber, S and Pick C. G, Quantitative somatosensory testing of subjects with Chronic Post Traumatic Headache – Response to the letter by Chua et al. Eur J Pain 15:542-43 (2011).  doi:10.1016/j.ejpain.2011.03.004

131.    Baratz, R., Tweedie, D., Rubovitch, V., Luo, W., Yoon, J.S., Hoffer, B.J., Greig N. H. and Pick, C. G. Tumor necrosis factor- synthesis inhibitor, 3’6,dithalidomide, reverse behavioral impairments induced by minimal traumatic brain injury in mice. J. Neurochem. 188:1032-42 (2011). doi:10.1111/j.1471-4159.2011.07377.x.

132.    Pick C. G., Rubovitch, V. Rachmany, L., Tweedie, D., Greig N. H., Hoffer, B.J. and Schreiber, S,.  A combat Zone-like Mouse Model of Blast Brain Injury: Possible Translational Study to the clinic. RTO-MP-HFM-207, 39-1-10 (2011).

133.    Rubovitch, V. Ten-Bosch, M., Zohar, O., Harrison, C., Tempel-Brami, C., Stein, E., Hoffer, B.J., Balaban, C.D., Schreiber, S., Chiu, W.T. and Pick C. G.  A Mouse Model of Blast-Induced mild Traumatic Brain Injury. Exp. Neurology, 232:280-89 (2011). doi:10.1016/j.expneurol.2011.09.018.

134.    Domachevsky, L., Pick C. G. Arieli, Y., Krinsky, N., Abramovich, A. and Eynan, M. Do hyperbaric oxygen-induced seizures cause brain damage? Epilepsy Res. 100:37-41 (2012).  doi:10.1016/j.eplepsyres.2012.01.004

135.    Saykally, J.N., Rachmany, L., Hatic, H., Shaer, A., Rubovitch, V., Pick, C. G. and Citron, B.A. The Nrf2 Activator, tert-Butylhydroquinone (tBHQ), Improves Cognitive Performance in Mice after Mild Traumatic Brain Injury. Neuroscience 223: 305-314(2012). doi:10.1016/j.neuroscience.2012.07.070

136.    Rachmany, L., Tweedie D., Li, Y., Rubovitch, V., Holloway, H.W., Miller, J., Hoffer, B.J., Greig, N.H. and Pick, C. G. Exendin-4 Induced Glucagon-like Peptide-1 Receptor Activation Reverses Behavioral Impairments of Mild Traumatic Brain Injury in Mice. Aging 35:1621-36 (2013). doi:10.1007/s11357-012-9464-0

137.    Tweedie, D,. Rachmany, L., Rubovitch, V., Lehrmann, E., Zhang, Y., Backer, K.G., Parez, E., Miller, J., Hoffer, B.J., Greig, N.H. and Pick, C. G. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice. Exp. Neurology, 239:170-82 (2013).  doi:10.1016/j.expneurol.2012.10.001

138.    Menachem, A., Chapman, J., Deri, Y., Pick, G. C. and Katzav, A. Immunoglobulin mediated neuro-cognitive impairment: review and preliminary experimental findings. Clinical Reviews in Allergy & Immunology 45:62-68 (2013).   doi:10.1007/s12016-013-8357-z

139.    Woods, A.S., Colsch, B., Jackson, S.N., Post, J., Baldwin, C., Roux, A., Hoffer, B.J., Cox, B., Hoffer M., Rubovitch,V. Pick, C. G. Schultz. J.A., and Balaban, C. Gangliosides and Ceramides Changes in a Mouse Model of a Blast Induced Traumatic Brain Injury. ACS Chemical Neuroscience 17:594-600 (2013).  doi:10.1021/cn300216h

140.    Domachevsky, L., Pick, C. G., Peled, N., Gomori, J.M., Abramovich, A. and Tempel-Brami, C.   MRI Findings after Hyperbaric Induced Seizures. Epilepsy Research 105: 62-68 (2013).     doi:10.1016/j.eplepsyres.2013.01.008

141.    Tweedie, D., Rachmany, L., Rubovitch, V., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J. *, Pick, C. G*. and Greig, N.H*. Physical- versus Blast-Traumatic Brain Injury: commonalities in cognitive dysfunction and hippocampal gene transcriptome in mice. Neurobiology of Disease 54:1-11 (2013). *Equal contribution.     doi:10.1016/j.nbd.2013.02.006

142.    Katzav, A., Ginsburg, D., Evert, T., Blank, M., Pick, C. G., Shoenfeld, Y. and Chapman, J. Coagulopathy Triggered Autoimmunity: Experimental Antiphospholipid Syndrome in Factor V Leiden Mice. BMC Medical 11:92 doi:10.1186/1741-7015-11-92 (2013). doi:10.1186/1741-7015-11-92

143.    Domachevsky, L., Rachmany, L., Barak, Y.,Rubovitch, V., Abramovich, A. and Pick, C. G. Do hyperbaric oxygen-induced seizures cause a transient decrement   in cognitive function. Neuroscience.  247: 328-334 (2013).     doi:10.1016/j.neuroscience.2013.05.052

144.    Rachmany, L., Tweedie, D., Rubovitch, V., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.G., Pick, C. G.*, Greg, N.H*. Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-a. PLoS One 28;8(11) (2013).  doi:10.1371/journal.pone.0079837

145.    Schreiber, S., Barak, J., Hostovsky, A., Baratz-Goldstein, R., Volis, I., Rubovitch, V. Pick, C. G. Interaction of different antidepressants with acute and chronic methadone in mice, and possible clinical implicatins. J. Molecular Neuroscience 52: 598-604 (2014).  doi:10.1007/s12031-013-0115-4

146.    Benaroya-Milshtein, N., Apter, A., Yaniv, I., Yuval, O., Stern, B., Bengal, Y., Kodman, Y., Shemer, E., Pick, G. C., Buchval, I. and Valevski A. Neuroimmunological function in parents of children suffering from cancer. Journal of Neural Transmission 121:299-306 (2014). doi:10.1007/s00702-013-1098-6

147.    Itsekson, Z., Maggio, N., Milman, A., Shavit, E., Pick C. G. and J. Chapman. Reversal of trauma-induced amnesia in mice by thrombin receptor antagonist. J. Molecular Neuroscience 53: 87-95 (2014).     doi:10.1007/s12031-013-0200-8

148.    Greg, N.H, Tweedie, D. Rachmany, L., Yu, Y., Rubovitch, V, Schreiber,S.,  Chiang, Y-H. Hoffer, B.J., Lahiri, D., Kumar Sambamurti, K., Becker,R.E.,  Pick, C. G. Incretin mimetics as pharmacological tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimer's & Dementia 10: S62-S75 (2014).    doi:10.1016/j.jalz.2013.12.011

149.    Eakin, K., Baratz-Goldstein, R., Pick, C. G., Zindel, O., Balaban, C.D., Hoffer, B.J., Hoffer, M.E. Lockwood, M. Miller, and Hoffer, B.J.  J. Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury. PLoS One 16;9(4) (2014).  doi:10.1371/journal.pone.0090617

150.    Katzav, A., Ben-Ziv, T., Blank M. Pick, C. G., Shoenfeld Y and Chapman, J.  Antibody-specific behavioral effects: Intracerebroventricular injection of antiphospholipid antibodies induces hyperactive behavior while anti-ribosomal-P antibodies induces depression and smell deficits in mice. Journal of Neuroimmunology 272:10-15(2014).  doi:10.1016/j.jneuroim.2014.04.003

151.    Schreiber, S., Lin, R., Haim, L., Baratz-Goldstien, R., Rubovitch, V., Waisman, N. and Pick, C. G. Enriched Environment Improves The Cognitive Effects From Traumatic Brain Injury In Mice. Behav Brain Res 271:59-64 (2014).  doi:10.1016/j.bbr.2014.05.060

152.    Lloyd, MC. Burke, N. Kalantapour, F. Niesen, MI. Hall, A. Pennypacker, K. Citron, B. Pick, C. G. Vernard A, V. Das, M.  Mohapatra, S. Cualing, H and Blanck, G. Quantitative morphological and molecular pathology 1 of the human thymus correlate with infant cause of death. Technology and Innovation 16: 55-62 (2014).     doi:10.3727/194982414X13971392823398

153.    Edut S., Rubovitch, V., Rehavi, M., Schreiber, S. and Pick, C. G. A study on the mechanism by which MDMA protects against dopaminergic dysfunction after minimal traumatic brain injury (mTBI) in mice.  J. Molecular Neuroscience 54: 684- 697 (2014).  doi:10.1007/s12031-014-0399-z

154.    Katzav A., Menachem A., Maggio, N., Pollak, L., Pick C. G., and Chapman J. IgG accumulates in inhibitory hippocampal neurons of experimental antiphospholipid syndrome. J. Autoimmunity 55: 86-93 (2014). doi:10.1016/j.jaut.2014.07.006

155.    Becker, M., Benromano, T., Shahar, A., Nevo, Z and Pick, C. G. Changes in the basal membrane of dorsal root ganglia Schwann cells explain the biphasic pattern of the peripheral neuropathy in streptozotocin-induced diabetic rats. J. Molecular Neuroscience 54: 704-713 (2014).  doi: 10.1007/s12031-014-0424-2

156.    Benromano, T., Defrin, R., Ahn, A. H., Zhao, J., Pick C. G and Levy, D. Closed-head injury promotes a selective trigeminal hyper-nociception: implication for the acute emergence of post traumatic headache.   Eur. J. Pain 19: 621-628 (2015).  doi:10.1002/ejp.583

157.    Defrin, R., Riabinin, M., Feingold, Y., Schreiber, S and Pick, C. G. Deficient pain modulation systems in chronic post traumatic headache. J. Neurotrauma 32: 28-37 (2015). doi:10.1089/neu.2014.3359

158.    Shavit-Stein, E., Itsekson, Z., Aronovich, A., Reisner, Y., Pick C. G.,  Tanne, D., Chapman, J. and Maggio, N. Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke. Scientific Reports 5: 7912  (2015).  doi:10.1038/srep07912

159.    Rubovitch, V., Baratz-Goldstein, R., Zilberstein, Y. and Pick, C. G. The involvement of the eIF2-alpha pathway in the neuroprotective effect of IGF-1 in mTBI. NeuroMolecular Med 17:58-70 (2015).   doi:10.1007/s12017-015-8340-3

160.    Baratz, R., Tweedie, D., Rubovitch, V., Hoffer, B.J., Greig N. H. and Pick, C. G. Pathophysiological mechanisms of minimal traumatic brain injury (mTBI): TNF-a synthesis inhibitor as a potential neuroprotective therapy. Journal of Neuroinflammation 12:45 (2015).  doi:10.1186/s12974-015-0237-4

161.    Yang, L-Y, Chu, Y-H, Tweedie, D., Yu, Q-S, Pick, C. G., Hoffer, B.J., Greig N. H. and Wang, J-Y. Post-trauma administration of the pifithrin-α oxygen analogue improves histological and functional outcomes after experimental traumatic brain injury. Experimental Neurology 269:56-66 (2015). doi:10.1016/j.expneurol.2015.03.015

162.    Ben Shimon, M., Lens, M., Ikenberg, B., Becker, D., Shavit Stein, E., Chapman, J. Tanne, D., Pick, C. G. Blatt, I., Neufeld, M., Vlachos A. and Maggio, N. Thrombin regulation of synaptic transmission and plasticity: implications for health and disease. Frontiers in Cellular Neuroscience 21; 9:151(2015).                doi:10.3389/fncel.2015.00151

163.    Defrin, R., Amanzio, M., Violeta Dimova, V., Filipovic, S., David Finn, D., Gimenez-Llort, L., Jensen-Dahm, C., Lautenbacher, S., Oosterman, J., Petrini, L., Pick, C. G., Pickering, G., de Tommaso, M., Invitto, S., Vase, L. and Kunz,M. Experimental pain processing in individuals with cognitive impairment: state of the art. Pain, 156:1396-1408 (2015).    doi:10.1097/j.pain.0000000000000195.

164.    Li Y., Bader, M., Pick C.G. and Greig, N.H. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice. J. Neurochem 135: 1203-1217 (2015).  doi:10.1111/jnc.13169.

165.    Baeta-Corral, R., Defrin, R., Pick C.G. and Lydia Giménez-Llort L.   Nociception response is preserved in 3xTg-AD mice. Neuroscience Letters 600:158-163 (2015).   doi:10.1016/j.neulet.2015.06.007.

166.    Tweedie, D., Rachmany, L., Rubovitch, V., Li, Y., Holloway, H.W., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J., Pick C.G*. and Greig, N.H. * Blast traumatic brain injury induced cognitive deficits associated with hippocampal neurodegeneration and changes in gene expression are attenuated by treatment with the glucagon-like peptide-1 receptor agonist, exendin-4. Alzheimer's & Dementia 12: 34-48 (2016). *Equal contribution. doi:10.1016/j.jalz.2015.07.489

167.    Leśniak, A., Sacharczuk, M., Chaim G. Pick, C.G. and Lipkowski, A.W. Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI) Neuropharmacology 101:506-518 (2016). doi:10.1016/j.neuropharm.2015.10.014.

168.    Levy D, Edut S., Baratz-Goldstein R., Rubovitch, V., Defrin, R., Zhao J. and Pick C.G. Responses of dural mast cells in concussive and blast models of closed-head mild traumatic brain injury: implications for post-traumatic headache. Cephalalgia 36:915-923 (2016). doi:10.1177/0333102415617412

169.    Feldman, R., Schreiber, S., Pick, C.G., Been, E., Physical characteristics in mental illness population - literature review. Journal of the Israel Physiotherapy Society (Hebrew), 18:40-58 (2016).

170.    Tweedie, D., Fukui, K., Li, Y., Barak, S., Tamargo, I., Rubovitch, V., Holloway, H.W., Hoffer, B.J. Becker, R.E., Pick, C.G. Greig, N.H.  Cognitive impairments induced by concussive mild traumatic brain injury in mouse are ameliorated by treatment with phenserine via multiple non-cholinergic mechanisms. PLoS One. 2016 11(6):e0156493.  doi:10.1371/journal.pone.0156493.

171.    Baratz-Goldstein, R., Deselms, H., Haim, L., Khomsky, L., Hoffer, B.J., Atlas, D. and Pick, C.G. Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild traumatic brain injury (mTBI). PLoS One. 2016 Jun 10;11(6):e0157064.         doi: 10.1371/journal.pone.0157064.

172.    Wang JY, Huang YN, Chou SY, Tweedie D, Lou W, Pick CG, Luo Y, Hoffer BJ, Greig NH, Wang JY Pomalidomide mitigates neuronal loss, neuroinflammation and behavioral impairments induced by controlled cortical impact traumatic brain injury in rat.  J Neuroinflammation. 2016:13(1):168.  doi:10.1186/s12974-016-0631-6.

173.    Weiss, R., Bitton, A., Ben Shimon, M., Elhaik- Goldman, S., Nahary, L., Cooper, I., Benhar I., Pick, C.G and Chapman J. Annexin A2, Autoimmunity, Anxiety and Depression. J Autoimmun 73: 92-99 (2016).  doi:10.1016/j.jaut.2016.06.011.

174.    Itsekson-Hayosh, Z.  Shavit-Stein, E., Katzav, A., Maggio, N., Harnof, S., Chapman, J. and Pick C.G. Minimal traumatic brain injury in mice – PAR-1 and thrombin related changes. J Neurotrauma 33:1848-1856 (2016).        doi:10.1089/neu.2015.4146.

175.    Deselms, H., Maggio, N., Rubovitch, V., Chapman, J. Schreiber, S., Tweedie, D., Kim, D.S, Greig, N.H Pick C.P. Novel Pharmaceutical Treatments for Minimal Traumatic Brain Injury and Evaluation of Animal Models and Methodologies Supporting their Development. Journal of Neuroscience Methods 272: 69-76 (2016). doi:10.1016/j.jneumeth.2016.02.002.

176.    Tweedie, D., Rachmany, L. Kim D.S., Rubovitch, V., Lehrmann, E., Zhang, Y., Becker, K.G., Perez, E., Hoffer, B.J., Pick C.G* and Greig, N.H. Mild traumatic brain injury-induced hippocampal gene expressions: the identification of target cellular processes for drug development. Journal of Neuroscience Methods. 272:4-18 (2016). doi:10.1016/j.jneumeth.2016.02.003.

177.    Schreiber, S., Bader, M., Rubovitch, V. and Pick, C.G. Interaction between methylphenidate, methadone and different antidepressants drugs in mice, and possible clinical implications. World J. Biol. Psychiatry 18:300-307 (2017). doi:10.3109/15622975.2015.1086492

178.    Benromano, T., Pick, C.G. Merik, J. and Defrin, R. Objective and subjective indicators of pain among individuals with cerebral palsy and intellectual disability. Pain Medicine 18: 441-453 (2017).

179.    Giménez-Llort L, and Pick C.G. Pain Assessment in Cognitively Impaired Animals. In: Pain in dementia. (Eds.) Lautenbacher, S and Gibson, S.J. pp. 354-362, IASP, (2017).

180.    Tamargo, I.A., Bader, M., Li, Y., Yu, S.J Wang, Y., Talbot, K., DiMarchi, R.D., Pick, C.G. and Greig, N.H. Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury. Exp. Neurology 288:176-186 (2017). doi: 10.1016/j.expneurol.2016.11.005.

181.    Benromano, T., Pick, C.G., Granovsky, Y. and Defrin, R. Comparison of pain evoked potentials and behavioral indices of pain among individuals with intellectual disability: a pilot study. Pain Medicine 18:1715-1730 (2017). doi:10.1093/pm/pnw349.

182.    Rubovitch, V., Zilberstein, Y. Chapman, J. Schreiber, S. and Pick, C.G. Restoring GM1 ganglioside expression ameliorates axonal outgrowth inhibition and cognitive impairments induced by blast traumatic brain injury. Scientific Reports (2017). 23;7:41269. doi: 10.1038/srep41269.

183.    Lesniak, A. Leszczynsk, P., Bujalska-Zadrozny, M., Chaim G. Pick, C.G. and Sacharczuk, M., Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity.  Behav. Brain Res. 326:209-216 (2017).  doi: 10.1016/j.bbr.2017.03.015   

184.    Rachmany, L., Tweedie, D., Rubovitch, V., Li, Y., Holloway, H.W., Ratliff, W.A., Saykally, J. N., Citron, B.A., Hoffer, B.J.,   Nigel H. Greig, N.G. and Pick, C.G. Exendin-4 attenuates blast traumatic brain injury induced cognitive impairments, losses of synaptophysin and in vitro TBI-induced hippocampal cellular degeneration.  Scientific Reports 7: 3735 (2017). doi:10.1038/s41598-017-03792-9

185.    Heim, L.R., Bader, M., Edut, S., Rachmany, L., Baratz-Goldstein, R., Lin, R., Rubovitch, V., Elpaz, A., Schreiber, S. and Pick, C.G. The Invisibility of Mild Traumatic Brain Injury: Impaired Cognitive Performance as a Silent Symptom. J Neurotrauma 34:2518-2528 (2017). doi: 10.1089/neu.2016.4909.

186.    Ben Shimon, M., Zaimer, T., Shavit- Stein, E., Artan- Furman, A., Chapman, J., Eisenkraft, A., Pick, C.G. and Maggio, N.  Recovery from trauma induced amnesia correlates with normalization of thrombin activity in the mouse hippocampus. PLoS One. 12(11):e0188524 (2017). doi: 10.1371/journal.pone.0188524.

187.    Sigler, A., Pick, C.G. and Been, E. Comparing anterior postural alignment between standing and supine position, in healthy young adults, through photographic measurement. Journal of the Israel Physiotherapy Society (Hebrew), 19:14-30 (2017).

188.    Baratz-Goldstein R., Toussia-Cohen S., A., Elipaz, Rubovitch V., Pick C. G. Immediate and delayed hyperbaric oxygen therapy as a neuroprotective treatment for traumatic brain injury in mice. Molecular and Cellular Neuroscience 83: 74-82 (2017). doi:10.1016/j.mcn.2017.06.004.

189.    Hoffer, B.J., Pick, C.G., Hoffer, M.E., Becker, R.E., Chiang, Y-H. and Greig, N.G. Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine. Journal of Biomedical Science 24:71(2017). doi:10.1186/s12929-017-0377-1

190.    Saykally, J.N., Ratliff, W.A., Keeley, K.L., Bhaskar, S., Pick, C.G. Mervis, R.F., Citron, B.A. Repetitive mild closed head injury alters protein expression and dendritic complexity in a mouse model. J Neurotraum 3:139-148 (2018). doi: 10.1089/neu.2017.5070.

191.    Schreiber, S., Bader, M., Rubovitch, V., Katz, Y., Cohen, E., Wolf, E, and Pick C. G. The effects of the synthetic cannabinoid AB-FUBINACA on body temperature, nociceptive threshold, locomotor parameters and anxiety in mice. Addiction Biology (2019). Addiction Biology 24:414-425. doi: 10.1111/adb.12606.

192.    Benady, A., Freidin, D., Pick, C.G. and Rubovitch, V. GM1 ganglioside prevents axonal regeneration inhibition and cognitivedeficits in a mouse model of traumatic brain injury. Scientific Reports doi: 10.1038/s41598-018-31623-y. (2018).

193.    Qubty, D., Glazer, S., Schrieber, S., Rubovitch, V, and Pick, C.G. Mild Traumatic Brain Injuries and Object Recognition. In: Handbook of Object Novelty Recognition. (Eds Ennaceur, Abdel and Silva, Maria A. de Souza. pp. 331-339, Elsevier, (2018).

194.    Maggio, N., Rubovitch, V., Hoffer, B.J., Citron, B.A., Greig, N.H, and Pick, C.G. Neuronal hyperexcitability following mTBI: cellular molecular mechanisms and therapeutical implications. In: Neurosensory Disorders in Mild Traumatic Brain Injury. (Eds.) Hoffer, M. and Balaban, C. pp. 67-81, Elsevier, (2019).

195.    Bader, M., Li, Y., Lecca, D., Rubovitch, V., Tweedie, D., Glotfelty, E., Kim, H.K., Choi, H., Hoffer, B.J., Pick, C.G., Greig, N. H. and Kim, D.S. Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury.   Neurobiology of Disease 124:439-453 (2019).

196.    Sigler, A., Pick, C.G. and Been, E. Supine position and body awareness effect on postural symmetry in healthy people. Gait and Posture 68: 476-48 (2019).

197.    Rubovitch, V., Pharayra, A., Har Even, M., Dvir O. and Pick, C.G. The neuroprotective effect of dietary restriction on a mouse model of traumatic brain injury. J.  Molecular Neuroscience 67: 613- 621 (2019). 3–621

198.    Ratliff, W.A., Schwartz, B., Rubovitch, V., Schreiber, S., Mervis, R.F., Citron, B.A. and Pick, CG. Effect of mild blast-induced TBI on dendritic connectivity of the basolateral amygdala in the mouse. Exp Neurology 315:9-14 (2019).

199.    Schreiber, S. and Pick, CG. Cannabis use during pregnancy: are we at the verge of defining a “cannabis fetal syndrome”? Medical Hypothesis 124: 53-55 (2019).

200.    Eger, M., Bader, M., Bree, D., Hadar, R., Nemerovski, A., Tam, J., Levy, D., Pick, CG. and Gabet, Y. Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by Cannabinoid-1 Receptor.  Scientific Reports 2019 Nov 7;9(1):16196.  doi: 10.1038/s41598-019-51720-w.

201.    Lecca D, Bader M, Tweedie D, Hoffman AF, Jung, YJ Hsueh S-C, Hoffer BJ, Becker RE, Pick CG, Lupica CR, Greig NH. (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer’s disease challenged mice. Neurobiol Dis. 2019 Oct;130:104528 (2019). doi: 10.1016/j.nbd.2019.104528.

202.    Feldman, R., Schreiber, S., Pick, CG., Been, E., Gait, balance, mobility and muscle strength in people with anxiety compared with healthy individuals. Human Movement Science 67: 102513 (2019). doi:10.1016/j.hunov.2019.102513

203.    Namdar, I., Feldman, R., Glazer, S., Meningher, I., Shlobin, NA., Rubovitch, V., Bikoveski L., Been, E. and Pick CG.  Motor Effects of mTBI in Mice. J.  Molecular Neuroscience 70:365-377   (2020).    Doi: 10.1007/s12031-019-01422-9

204.    Li,Y.,  Glotfelty, E.J., Namdar, I., Tweedie, D.,  Olson, L., Hoffer, B.J.,   DiMarchi, R.D., Pick, C.G. and Greig, N.H.  Neurotrophic      and neuroprotective effects of a monomeric GLP-1/GIP/Gcg receptor triagonist in cellular and rodent models of mild traumatic brain injury. Exp. Neurology 324:113113 (2020). doi: 10.1016/j.expneurol.2019.113113.

205.    Schreiber, S., and Pick, C.G. Trazodone and Mirtazapine: A possible opioid   involvement in their use (at low dose) for sleep? Medical Hypothesis  2020; 136:109501 (2020). doi: 10.1016/j.mehy.2019.109501.

206.    Levy, D., Gruener, H., Riabinin, M., Feingold, Y., Schreiber, C., Pick, C.G. and Defrin, R. Different clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles. Cephalalgia 40: 675-688 (2020).   doi: 10.3389/fcell.2019.00356. 

207.    Ben Shimon, M., Shavit-Stein, E., Altman, K., Pick, CG. and Maggio, N.    Thrombin as key mediator of seizure development following traumatic brain injury. Frontiers in Pharmacology 10:1532 (2020). http://doi: 10.3389/fphar.2019.01532. eCollection 2019.

208.    Bader, M., Li, Y., Tamargo, I., Tweedie, D., Shlobin, N., Bernstein, A., Rubovitch,V., Dimarchi, R.D., Hoffer B.J., Greig N.H. and Pick, C.G. Neuroprotective effects and treatment potential of Incretin mimetics in a murine model of mild traumatic brain injury. Front. Cell Dev. Biol. Vol.7 Article 356 (2020).

209.    Feldman, R., Schreiber, S., Pick, CG., Been, E., Gait, balance and posture in major mental illnesses: Depression, anxiety and Schizophrenia.  Austin Med Sci. 5(1): 1039 (2020).

210.    Ratliff, W.A., Mervis, R.F., Citron, B.A., Schwartz, B., Rubovitch, V., Schreiber, S., and Pick, C.G. Effect of mild blast-induced TBI on dendritic architecture of the cortex and hippocampus in the mouse. Scientific Reports 10:2206 (2020). 1

211.    Ratliff, W.A., Qubty, D., Delic, V., Pick, C.G and Citron B. A. Repetitive Mild      Traumatic Brain Injury and Transcription Factor Modulation. J Neurotrauma  (2020)

212.    Meningher, I., Bernstein-Eliav, M., Rubovitch, V., Pick, CG and Tavor, I. Alteration in Network Connectivity Following Traumatic Brain Injury in Mice. J. Neurotrauma (2020). https://doi: 10.1089/neu.2020.7063. 

213.    Farbstein, D., Hollander, N., Peled, O., Apter, A.,  Fennig, S.,  Haberman, Y.,   Halpert, H., Yaniv, I., Shkalim, V. Pick, CG., and Benaroya-Milshtein, N. Social isolation in mice: behavior, immunity and tumor growth. Stress (In Press). 

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