Carmit Levy wins 2023 DKFZ-MOST collaborative grant between Israel and Germany

DKFZ-MOST is a collaborative grant between Israel and Germany, between the Israeli Ministry of Science and the DKFZ (German Cancer Research Center).

The team: Dr. Jeroen Krijgsveld from the Division of Proteomics of Stem Cells and Cancer at the DKFZ and myself. 

Dr. Jeroen Krijgsveld is world leader in global and chromatin-directed proteomics. 

Proposal Title: Revealing the role of MITF in UV-induced DNA repair and induction of genetic alterations in primary melanoma

We aim to explore the role of MITF in DNA repair by combining chromatin-directed proteomics with functional assays, to comprehensively determine the dynamic interactome of MITF in chromatin of all stages of melanoma under UV exposure. Further, we aim to delineate the mechanisms that lead to genetic alterations that fail to be repaired by MITF, or that are MITF-independent. Identification of such lesions that induce primary melanomas could yield biomarkers to improve diagnosis and prognosis.

Prof. Carmit Levy is in the Department of Human Molecular Genetics and Biochemistry. She performed her PhD at the Hebrew University of Jerusalem and her post-doctoral training at the Harvard Medical School and Broad Institute. Since establishing her research team, Levy received the ERC Consolidator Award, the Rector and Dean Excellence in Teaching Awards, and the International Young Melanoma Investigator Award of the Society of Melanoma Research.

https://carmitlevylab.com/