Dr. Mordechai Gerlic's Paper is Out Now in Nature Immunology
"Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model"
13 February 2019
Inflammasomes are one of the most important mechanisms for innate immune defense against microbial infection but are also known to drive various inflammatory disorders via processing and release of the cytokine IL-1β.
Dendritic cells (DCs) have been long time suggested to express a functional inflammasomes. Gerlic Lab and colleagues demonstrate, however, that bone marrow–derived DCs completely lack NLRP3 inflammasome activity and that the bulk of splenic DCs lack or have only minimal activity.
Future studies, which will clarify whether some of the DC populations do indeed have inflammasome potential, will shed light on our understanding of microbial clearance and the pathogenesis of rare hereditary and common inflammatory diseases.
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