Yitzhak Reizel- DNA Methylation and FoxA Pioneer Factors Regulate Liver Stability and Plasticity

You are cordially invited to a special seminar of the Department of Human molecular Genetics and Biochemistry Sackler Faculty of Medicine

By: Yitzhak Reizel, Ph.D.

Faculty of Medicine, Genetics Department, University of Pennslyvania, Philadelphia, Pennsylvania, USA

Title: DNA Methylation and FoxA Pioneer Factors Regulate Liver Stability and Plasticity 

Abstract:

Pioneer factors play a critical role in differentiation by generating chromatin accessibility and by activating enhancers. As differentiation progress, additional tissue-specific transcription factors bind these enhancers thus generating a stable and robust regulatory network that is thought to be resistant to the loss of any specific transcription factor. I found that pioneer factors are continuously guarding enhancer activity throughout adult life thus maintaining tissue integrity. An exception to this is DNA hypomethylation at these sites that are programmed by pioneer factors in embryonic development and are not dependent on the continuous presence of pioneer factors in the adult tissue. These findings distinguish between cellular components that enhance stability versus those that enable plasticity.     

The Seminar will take place on Sunday, December 20th, 2020 at 15:00

via Zoom:

https://us02web.zoom.us/j/82097287967

Meeting ID: 820 9728 7967