Dr. Rachel Sarig

School of Dentistry
ביה"ס לרפואת שינים סגל אקדמי בכיר
Dr. Rachel Sarig
Phone: 03-6406569
Another phone: 03-6409363
Fax: 03-6409363
Office: School of Dental Medicine, 04

Research

 
 
 
 

Senior lecturer, the Department of Orthodontics, the Department of Oral Biology, the Maurice and Gabriela Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University.

Researcher, Shmunis Family Anthropology Institute, the Dan David Center for Human Evolution and Biohistory Research, Sackler Faculty of Medicine, Tel Aviv University.

 

Education

 

 

      Having completed my D.M.D., Ph.D. in anatomy and anthropology, and post-graduate studies in orthodontics, at the Sackler Faculty of Medicine, I was exposed to a unique field of research: dental anthropology. I realized that looking back at our ancestors and studying their anatomy and physiology could help us evaluate some of the trends that modern humans are facing, for instance the decrease in the size of jaws and teeth and the increase in dental pathologies and anomalies. All should be evaluated on a wide evolutionary scale, from the prehistoric to modern humans, in order to allow for a better understanding of human physiology.

       After completing my postdoctoral training at the Tel Aviv University Anthropological Collection, I established the ‘Dental Anthropology Laboratory’ in the Goldschleger School of Dental Medicine at TAU. Together with my colleagues, we have inaugurated the Dan David Center (DDC) for Human Evolution and Biohistory Research and the Shmunis Family Anthropology Institute, both affiliated with the Sackler Faculty of Medicine, TAU.

      Currently, I am a curator and researcher at the DDC and the head of the µCT imaging and histological laboratories at the Shmunis Family Anthropology Institute. As a dental anthropologist, I take an active part in archaeological excavations, and am very often excited to discover prehistoric human remains. As part of my position, I am frequently requested to analyse and define the origin of prehistoric teeth. I have developed a particular interest in virtual geometric morphometric analysis and have generated new methodologies based on µCT scans of teeth.

       This is relevant to my desire to fill the lacuna currently hampering the process of identifying prehistoric remains due to the lack of a robust and practical method to explore human development based on teeth. Using my group knowledge and unique research approach as dentists and anthropologists, we have focused our efforts on developing new methodologies to study prehistoric populations. My group main interest is the investigation of dental anthropology, dental biomechanics and the masticatory system. The study of the masticatory apparatus is conducted both in prehistoric and modern societies using laboratory models, µCT scans and clinical studies.

 

 

Academic Appointments

Facial and Dental Anthropology:
Evolutionary aspects in physiological and pathological processes in human dentition

 

       Many of the current oral diseases and malformations have their roots in our evolutionary history. Knowing the evolutionary processes that led to the current shape and size of our skull and mandible may greatly bear on our understanding of phenomena such as malocclusions (i.e., crowding, rotation, overbite), dental malformations ( i.e. impaction, missing and supernumerary teeth) and oral diseases (caries, attrition, periodontal diseases). Treatment strategy should take into consideration evolutionary reasoning involved in shaping our face and jaws, ignoring them may end, in the long run, in treatments’ failure.

       Understanding the evolutionary constrains that have acted through time on our masticatory system may help us planning and establishing better treatment strategies. Long-term evolutionary processes such as decrease in jaws and teeth size, higher prevalence of impacted teeth and the loss of teeth in the arch, are all important factors that should be considered.

       The group main interest is the investigation of dental anthropology, dental biomechanics and the masticatory system. The study of the masticatory apparatus is conducted both in prehistoric and modern societies using laboratory models, microCT scans and clinical studies:

Determining the origin of modern humans – development and migration

Evolution of human health, the origin of diseases and medical treatment

Dynamics of human demographics

Osteology, biological anthropology and the study of human culture

Awards and Prizes

The full list can be found in: google scholar  https://scholar.google.com/citations?user=EmiIhDEAAAAJ&hl=en&oi=ao

Selected publications:

  1. Hershkovitz I, Weber GW, Quam R, Duval M, Grün R, Kinsley L, Ayalon A, Bar-Matthews M, Valladas H, Mercier N, Arsuaga JL, Martinón-Torres M, Bermúdez de Castro JM, Fornai C, Martín-Francés L, Sarig R, May H, Krenn VA, Slon V, Rodríguez L, García R, Lorenzo C, Carretero JM, Frumkin A, Shahack-Gross R, Bar-Yosef Mayer DE, Cui Y, Wu X, Peled N, Groman-Yaroslavski I, Weissbrod L, Yeshurun R, Tsatskin A, Zaidner Y, Weinstein-Evron M. The Earliest Modern Humans outside Africa. Science, 2018 359(6374), 456-459.
  2. Pokhojaev A, Habashi W, May H, Schulz-Kornas E, Shvalb N, Sarig R. Examination of the interproximal wear mechanism: Facet morphology and surface texture analysis.  Journal of Dental Research, 2018 97(13):1445-1451
  3. Harney É, May H, Shalem D, Rohland N, Mallick S, Lazaridis I, Sarig R, Stewardson K, Nordenfelt S, Patterson N, Hershkovitz I, Reich D. Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation. Nature Communications 2018 9(1):3336.
  4. Schnaider L, Ghosh M, Bychenko D, Grigoriants I, Ya'ari S, Shalev Antsel T, Matalon S, Sarig R, Brosh T, Pilo R, Gazit E, Adler-Abramovich L. Enhanced nanoassembly-incorporated antibacterial composite materials. ACS Applied Materials & Interfaces 2019 11(24):21334-21342.
  5. Pokhojaev A, Avni H, Sella-Tunis T, Sarig R, May H. Changes in human mandibular shape during the Terminal Pleistocene-Holocene Levant. Scientific Reports, 2019 Jun; 9(1):8799.
  6. Sarig R, Fornai, C., Pokhojaev, A., May, H., Hans, M., Barzilai, O., Quam, R., Weber, G.W.  The dental remains from the Early Upper Paleolithic of Manot Cave, Israel. Journal of Human Evolution, 2019 102648.
  7. Levartovsky S, Aharonov O, Emodi Perlman A, Winocur E, Sarig R. The effect of tooth wear, age and sex on facial height assessed by soft tissue analysis. Journal of Oral Rehabilitation, 2020 47(3), 346-352.
  8. Vardimon AD, Shpack N, Wasserstein A, Skyllouriotou M, Strauss M, Geron S, Sadan N, Levartovsky S, Sarig R. Upper lip horizontal line: Characteristics of a dynamic facial line. International Journal of Environmental Research and Public Health. 2020 17(18):6672.
  9. Beitlitum I, Barzilay V, Rayyan F, Sebaoun A, Sarig R. Post-orthodontic lower incisors recessions: Combined periodontic and orthodontic approach. International Journal of Environmental Research and Public Health. 2020 17(21):8060.
  10. Nudel I, Pokhojaev A, Hausman BS, Bitterman Y, Shpack N, May H, Sarig R. Age estimation of fragmented human dental remains by secondary dentin virtual analysis. International Journal of Legal Medicine. 2020 Sep;134(5):1853-60.
  11. Elbahary S, Haj-Yahya S, Khawalid M, Tsesis I, Rosen E, Habashi W, Pokhojaev A, Sarig R. Effects of different irrigation protocols on dentin surfaces as revealed through quantitative 3D surface texture analysis. Scientific Reports, 2020 Dec 16;10(1):22073
  12. Yossi Zaidner, Laura Centi, Marion Prévost, Norbert Mercier, Christophe Falguères, Gilles Guérin, Hélène Valladas, Maïlys Richard, Asmodée Galy, Christophe Pécheyran, Olivier Tombret, Edwige Pons-Branchu, Naomi Porat, Ruth Shahack-Gross, David E. Friesem, Reuven Yeshurun, Zohar Turgeman-Yaffe, Amos Frumkin, Gadi Herzlinger, Ravid Ekshtain, Maayan Shemer, Oz Varoner, Sarig R*, Hila May*, Israel Hershkovitz*. Middle Pleistocene Homo behavior and culture at 140,000 to 120,000 years ago and interactions with Homo sapiens.  Science 2021 372(6549), pp.1429-1433.*equal contribution
  13.   Israel Hershkovitz*, Hila May*, Sarig R *, Ariel Pokhojaev, Dominique Grimaud-Hervé, Emiliano Bruner, Cinzia Fornai, Rolf Quam, Juan Luis Arsuaga, Viktoria A. Krenn, Maria Martinón-Torres, Jose Maria Bermúdez de Castro, Viviane Slon, Lou Albessard-Ball, Amélie Vialet, Tim Schüler, Giorgio Manzi, Antonio Profico, Fabio Di Vincenzo, Gerhard W. Weber, Yossi Zaidner. A Middle Pleistocene Homo from Nesher Ramla, Israel. Science. 2021 372(6549), pp.1424-1428.*equal contribution
  14. Nudel, I., Pokhojaev, A., Bitterman, Y., Shpack, N., Fiorenza, L., Benazzi, S. and Sarig R. Secondary Dentin Formation Mechanism: The Effect of Attrition.  International Journal of Environmental Research and Public Health, 2021 18(19) 9961.
  15. Habashi, W., Bader-Farraj, A., Shpack, N., Beitlitum, I., May, H., Sarig R. Three-dimensional surface texture analysis of fluoride’s effect on enamel erosionJournal of Clinical Medicine, 2021 10(19):4528.
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