Prof. Oren Kobiler

Senior Lecturer, Sackler Faculty of Medicine

Investigating Viral Genetic Diversity

 

Our research is focused on understanding how viruses generate and maintain genetic diversity. All virus populations display high genomic diversity, which provides opportunities for survival in the constantly changing environment. In many cases, such diversity results in failure of antiviral treatment (resistance to vaccines and antiviral drugs) and the emergence of zoonotic viral pathogens. DNA viruses and segmented RNA viruses exploit recombination and reassortment as mechanisms for diversity creation. We are interested in the mechanisms allowing DNA viral recombination and finding ways to inhibit these mechanisms.

 

 

A Single Herpes Simplex Virus 1 Genome Reactivates from Individual Cells 2022

D Rafael, E Tomer, O Kobiler

Microbiology Spectrum 10 (4), e01144-22

 

Insular cortex neurons encode and retrieve specific immune responses 2021

T Koren, M Amer, M Krot, N Boshnak, TL Ben-Shaanan, H Azulay-Debby, ...

Cell 184 (24), 5902-5915. e17

 

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors 2021

M Mor, M Werbner, J Alter, M Safra, E Chomsky, JC Lee, S Hada-Neeman, ...

PLoS pathogens 17 (2), e1009165

 

The fate of incoming HSV-1 genomes entering the nucleus 2021

O Kobiler, A Afriat

Current Issues in Molecular Biology 41 (1), 221-266

 

Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2020

A Shitrit, D Zaidman, O Kalid, I Bloch, D Doron, T Yarnizky, I Buch, I Segev, ...

Scientific reports 10 (1), 1-11

 

Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate 2020

EM Cohen, N Avital, M Shamay, O Kobiler

Proceedings of the National Academy of Sciences 117 (1), 635-640

 

Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses 2019

E Tomer, EM Cohen, N Drayman, A Afriat, MD Weitzman, A Zaritsky, ...

The FASEB journal 33 (8), 9388-9403

 

Herpes simplex virus replication compartments: From naked release to recombining together 2019

O Kobiler, MD Weitzman

PLoS pathogens 15 (6), e1007714

 

Dynamic proteomics of herpes simplex virus infection 2017

N Drayman, O Karin, A Mayo, T Danon, L Shapira, D Rafael, A Zimmer, ...

MBio 8 (6), e01612-17

 

Promoting simultaneous onset of viral gene expression among cells infected with herpes simplex virus-1 2017

M Ralph, M Bednarchik, E Tomer, D Rafael, S Zargarian, M Gerlic, ...

Frontiers in Microbiology 8, 2152

 

Gene expression correlates with the number of herpes viral genomes initiating infection in single cells 2016

EM Cohen, O Kobiler

PLoS pathogens 12 (12), e1006082       

 

Histone deacetylase inhibitors reduce the number of herpes simplex virus-1 genomes initiating expression in individual cells 2016

L Shapira, M Ralph, E Tomer, S Cohen, O Kobiler

Frontiers in microbiology 7, 1970

 

Vaccination strategies against respiratory syncytial virus 2016

D Yamin, FK Jones, JP DeVincenzo, S Gertler, O Kobiler, JP Townsend, ...

Proceedings of the National Academy of Sciences 113 (46), 13239-13244            

 

A ‘tool box’for deciphering neuronal circuits in the developing chick spinal cord 2014

Y Hadas, A Etlin, H Falk, O Avraham, O Kobiler, A Panet, A Lev-Tov, ...

Nucleic acids research 42 (19), e148-e148

 

Virus strategies for passing the nuclear envelope barrier 2012

O Kobiler, N Drayman, V Butin-Israeli, A Oppenheim

Nucleus 3 (6), 526-539

 

Alphaherpesvirus axon-to-cell spread involves limited virion transmission 2012

MP Taylor, O Kobiler, LW Enquist

Proceedings of the National Academy of Sciences 109 (42), 17046-17051