Senior Lecturer, Sackler Faculty of Medicine
Dr. Oren Kobiler
Investigating Viral Genetic Diversity
Our research is focused on understanding how viruses generate and maintain genetic diversity. All virus populations display high genomic diversity, which provides opportunities for survival in the constantly changing environment. In many cases, such diversity results in failure of antiviral treatment (resistance to vaccines and antiviral drugs) and the emergence of zoonotic viral pathogens. DNA viruses and segmented RNA viruses exploit recombination and reassortment as mechanisms for diversity creation. We are interested in the mechanisms allowing DNA viral recombination and finding ways to inhibit these mechanisms.
Publications & Grants
Kobiler O., Lipman Y., Therkelsen K., Daubechies I., and Enquist L.W. (2010). Herpesviruses carrying a Brainbow cassette reveal replication and expression of limited numbers of incoming genomes. Nat. Commun. 1:146.
*Kobiler O., *Card J.P., McCambridge J., Ebdlahad S., Shan Z., Raizada M.K., Sved A.F., and Enquist L.W. (2011). Microdissection of neural networks by conditional reporter expression from a Brainbow Herpesvirus. Proc Natl Acad Sci U S A. 108:3377-82.
*Kobiler O., *Card J.P., Ludmir E.B., Desai V., Sved A.F., Enquist L.W. (2011). A dual infection pseudorabies virus conditional reporter approach to identify projections to collateralized neurons in complex neural circuits. PLoS One, 6:e21141.
Kobiler, O., Brodersen, P., Taylor, M.P., Ludmir, E.B. and L.W. Enquist. (2011). Herpesvirus replication compartments originate with single incoming viral genomes. mBio 2:e00278-11. doi:10.1128/mBio.00278-11.
Taylor MP, Kobiler O, Enquist LW. (2012) Alphaherpesvirus axon-to-cell spread involves limited virion transmission. Proc Natl Acad Sci USA. 109:17046-51.
Hadas, Y., Etlin, A., Falk, H., Avraham, O., Kobiler, O., Panet, A., Lev-Tov, A. and Avihu Klar (2014) A ‘tool box’ for deciphering neuronal circuits in the developing chick spinal cord. Nucl. Acids Res. doi: 10.1093/nar/gku750
Szpara M.L., Kobiler O., and Enquist L.W. (2010). A comon neuronal response to alphaherpesvirus infection. J Neuroimmune Pharmacol. 5:418-27.
Kobiler O, Drayman N, Butin-Israeli V, Oppenheim A. (2012) Virus strategies for passing the nuclear envelope barrier. Nucleus. 3:526-39.
2013-2017 - Herpes simplex virus-1 bottleneck during genome replication. Marie Curie Integration Grants FP7-PEOPLE.
2014-2019 - Characterization of the bottleneck limiting the number of incoming HSV-1 genomes being expressed per cell. Israel Science Foundation
2014-2015 - Equipment grant for new faculty, Israel Science Foundation