Senior Lecturer, Sackler Faculty of Medicine
Prof. Oren Kobiler
Investigating Viral Genetic Diversity
Our research is focused on understanding how viruses generate and maintain genetic diversity. All virus populations display high genomic diversity, which provides opportunities for survival in the constantly changing environment. In many cases, such diversity results in failure of antiviral treatment (resistance to vaccines and antiviral drugs) and the emergence of zoonotic viral pathogens. DNA viruses and segmented RNA viruses exploit recombination and reassortment as mechanisms for diversity creation. We are interested in the mechanisms allowing DNA viral recombination and finding ways to inhibit these mechanisms.
A Single Herpes Simplex Virus 1 Genome Reactivates from Individual Cells 2022
D Rafael, E Tomer, O Kobiler
Microbiology Spectrum 10 (4), e01144-22
Insular cortex neurons encode and retrieve specific immune responses 2021
T Koren, M Amer, M Krot, N Boshnak, TL Ben-Shaanan, H Azulay-Debby, ...
Cell 184 (24), 5902-5915. e17
Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors 2021
M Mor, M Werbner, J Alter, M Safra, E Chomsky, JC Lee, S Hada-Neeman, ...
PLoS pathogens 17 (2), e1009165
The fate of incoming HSV-1 genomes entering the nucleus 2021
O Kobiler, A Afriat
Current Issues in Molecular Biology 41 (1), 221-266
Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 2020
A Shitrit, D Zaidman, O Kalid, I Bloch, D Doron, T Yarnizky, I Buch, I Segev, ...
Scientific reports 10 (1), 1-11
Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate 2020
EM Cohen, N Avital, M Shamay, O Kobiler
Proceedings of the National Academy of Sciences 117 (1), 635-640
Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses 2019
E Tomer, EM Cohen, N Drayman, A Afriat, MD Weitzman, A Zaritsky, ...
The FASEB journal 33 (8), 9388-9403
Herpes simplex virus replication compartments: From naked release to recombining together 2019
O Kobiler, MD Weitzman
PLoS pathogens 15 (6), e1007714
Dynamic proteomics of herpes simplex virus infection 2017
N Drayman, O Karin, A Mayo, T Danon, L Shapira, D Rafael, A Zimmer, ...
MBio 8 (6), e01612-17
Promoting simultaneous onset of viral gene expression among cells infected with herpes simplex virus-1 2017
M Ralph, M Bednarchik, E Tomer, D Rafael, S Zargarian, M Gerlic, ...
Frontiers in Microbiology 8, 2152
Gene expression correlates with the number of herpes viral genomes initiating infection in single cells 2016
EM Cohen, O Kobiler
PLoS pathogens 12 (12), e1006082
Histone deacetylase inhibitors reduce the number of herpes simplex virus-1 genomes initiating expression in individual cells 2016
L Shapira, M Ralph, E Tomer, S Cohen, O Kobiler
Frontiers in microbiology 7, 1970
Vaccination strategies against respiratory syncytial virus 2016
D Yamin, FK Jones, JP DeVincenzo, S Gertler, O Kobiler, JP Townsend, ...
Proceedings of the National Academy of Sciences 113 (46), 13239-13244
A ‘tool box’for deciphering neuronal circuits in the developing chick spinal cord 2014
Y Hadas, A Etlin, H Falk, O Avraham, O Kobiler, A Panet, A Lev-Tov, ...
Nucleic acids research 42 (19), e148-e148
Virus strategies for passing the nuclear envelope barrier 2012
O Kobiler, N Drayman, V Butin-Israeli, A Oppenheim
Nucleus 3 (6), 526-539
Alphaherpesvirus axon-to-cell spread involves limited virion transmission 2012
MP Taylor, O Kobiler, LW Enquist
Proceedings of the National Academy of Sciences 109 (42), 17046-17051