Dr. Noam Shomron

ביולוגיה תאית והתפתחותית סגל אקדמי בכיר
Dr. Noam Shomron
Phone: 03-6406594
Another phone: 03-6407387
Fax: 03-6407432
Office: Sackler School of Medicine, 303

Positions

Senior Lecturer, Department of Cell and Developmental Biology, Sackler Faculty of Medicine

Director, Functional Genomics Laboratory

Academic Director, BioAbroad

Editor-in-Chief, Genetics Research

 

Biography

Dr. Noam Shomrom joined Tel Aviv University’s Faculty of Medicine as a lecturer and Principal Investigator (PI) in October 2008. Prior to this appointment he was a Post-Doctorate Affiliate at MIT, Cambridge, MA. During his training at MIT he combined high-throughput methods with computational analysis. 

 

In the past few years, he has looked for ways to broaden his managerial and leadership skills beyond scientific activities and achievements. In this capacity he gives scientific lectures about the marvel of the human genome to broad-background crowds; he took several managerial courses at MIT's Sloan School of management; he participated in MIT's artificial intelligence initiatives; he was involved in founding BioAbroad, a non-profit organization encompassing Israeli bio-related academics overseas (currently there are >1000 members); he also initiated RGI-Israel (Rare Genomics Institute; in collaboration with RGI-USA) assisting patients with rare genetic diseases.

 

Research

Genomics and Gene Regulation by Small RNAs

Our laboratory focuses on the analysis of regulation of gene expression aimed at understanding human disease. Combining high-throughput methods and bioinformatics, one aspect of our team’s research explores microRNA regulation in order to reach a global, systems perspective of the mechanistic roles microRNAs play during disease development. Among our projects:

  • Identification of a microRNA molecule that controls several oncogenes. Their discovery is paving the way for a potentially revolutionary drug for cancer treatment.
  • Revealing the influence of microRNAs on pharmacogenomics and personalized medicine, thus leading to tailored drugs for cancer treatment.
  • Exposing pathogens in human tissues based on deep sequencing of small RNA molecules followed by subtraction and assembly of the various genomes.

 

Recent Publications

Publications (Selected)

Gilam A, Conde J, Weissglas-Volkov, Oliva N, Friedman E, Artzi N, Shomron N. Local microRNA delivery targets Palladin and prevents metastatic breast cancer. Nat Commun. In press.

 

Hadar A, Milanesi E, Squassina A, Niola P, Chillotti C, Pasmanik-Chor M, Yaron O, Martásek P, Rehavi M, Weisglass-Volkov D, Shomron N, Gozes I, Gurwitz D. RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer’s disease: genomewide transcriptomic profiling and bioinformatics data mining. Transl Psychiatry. In press.

 

Rzezniczek S, Obuchowicz M, Datka W, Siwek M, Dudek D, Kmiotek K, Oved K, Shomron N, Gurwitz D, Pilc A. Decreased sensitivity to paroxetine-induced inhibition of peripheral blood mononuclear cell growth in depressed and antidepressant treatment-resistant patients. Transl Psychiatry. 2016;31;6(5):e827.

 

Hillman Y, Mazkereth N, Farberov L, Shomron N, Fishelson Z. Regulation of complement-dependent cytotoxicity by microRNAs miR-200b, miR-200c, and miR-217. J Immunol. 2016;196(12):5156-65.

 

Lin T, Simchovitz A, Shenhar-Tsarfaty S, Vaisvaser S, Admon R, Hanin G, Hanan M, Kliper E, Bar-Haim Y, Shomron N, Fernandez G, Lubin G, Fruchter E, Hendler T, Soreq H. Intensified vmPFC surveillance over PTSS under perturbed microRNA-608/AChE interaction. Transl Psychiatry. 2016;3;6:e801.

 

Eskin-Schwartz M, Metzger Y, Peled A, Weissglas- Volkov D, Malchin N, Gat A, Vodo D, Mevorah B, Shomron N, Sprecher E, Sarig O. Somatic mosaicism for a “lethal” GJB2 mutation results in a patterned form of spiny hyperkeratosis without eccrine involvement. Pediatr Dermatol. 2016;33(3):322-6.

 

Ivancic-Jelecki J, Forcic D, Jagusic M, Kosutic-Gulija T, Mazuran R, Lang Balija M, Isakov O, Shomron N. Influence of population diversity on neurovirulence potential of plaque purified L-Zagreb variants. Vaccine. 2016 Apr 29;34(20):2383-9.

 

Abramowitz Y, Roth A, Keren G, Isakov O, Shomron N, Laitman Y, Weissglas-Volkov D, Arbel Y, Banai S, Finkelstein A, Friedman E. Whole-exome sequencing in individuals with multiple cardiovascular risk factors and normal coronary arteries. Coron Artery Dis. 2016;27(4):257-66.

 

Menachem A, Makovski V, Bodner O, Pasmanik-Chor M, Stein R, Shomron N, Kloog Y. Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy. Oncotarget. 2016;7(11):12489-504.

 

Inberg S, Jacob E, Elkobi A, Edry E, Rappaport A, Simpson TI, Armstrong JD, Shomron N, Pasmanik-Chor M, Rosenblum K. Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex. Mol Brain. 2016;9:13.

 

Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R, Satchi- Fainaro R. Identification of dormancy-associated microRNAs for the design of osteosarcoma-targeted dendritic polyglycerol nanopolyplexes. ACS Nano. 2016;10(2):2028-45.

 

Stapleford KA, Moratorio G, Henningsson R, Chen R, Matheus S, Enfissi A, Weissglas-Volkov D, Isakov O, Blanc H, Mounce BC, Dupont-Rouzeyrol M, Shomron N, Weaver S, Fontes M, Rousset D, Vignuzzi M. Whole-genome sequencing analysis from the chikungunya virus caribbean outbreak reveals novel evolutionary genomic elements. PLoS Negl Trop Dis. 2016;10(1):e0004402.

 

Vaisvaser S, Modai S, Farberov L, Lin T, Sharon H, Gilam A, Volk N, Admon R, Edry L, Fruchter E, Wald I, Bar-Haim Y, Tarrasch R, Chen A, Shomron N, Hendler T. Neuro-Epigenetic Indications of Acute Stress Response in Humans: The case of microRNA- 29c. PLoS One. 2016;11(1):e0146236.

 

Pillar N, Isakov O, Weissglas-Volkov D, Botchan S, Friedman E, Arber N, Shomron N. Actionable clinical decisions based on comprehensive genomic evaluation in asymptomatic adults. Mol Genet Genomic Med. 2015;3:433-9.

 

Pras E, Kristal D, Shoshany N, Volodarsky D, Vulih I, Celniker G, Isakov O, Shomron N, Pras E. Rare genetic variants in Tunisian Jewish patients suffering from age-related macular degeneration. J Med Genet. 2015;52:484-92.

 

Bordería AV, Isakov O, Moratorio G, Henningsson R, Agüera-González S, Organtini L, Gnädig NF, Blanc H, Alcover A, Hafenstein S, Fontes M, Shomron N, Vignuzzi M. Group selection and contribution of minority variants during virus adaptation determines virus fitness and phenotype. PLoS Pathog. 2015;11:e1004838.

 

Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U, Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E, Meilik B, Petit I, Aberdam D, Paus R, Sprecher E, Nousbeck J. RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp Dermatol. 2015;24:618-22.

 

Haer-Wigman L, Newman H, Leibu R, Bax NM, Baris HN, Rizel L, Banin E, Massarweh A, Roosing S, Lefeber DJ, Zonneveld-Vrieling MN, Isakov O, Shomron N, Sharon D, Den Hollander AI, Hoyng CB, Cremers FP, Ben-Yosef T. Non-syndromic retinitis pigmentosa due to mutations in the mucopolysaccharidosis type IIIC gene, heparanalpha- glucosaminide N-acetyltransferase (HGSNAT). Hum Mol Genet. 2015;24:3742-51.

 

Smith EC, Case JB, Blanc H, Isakov O, Shomron N, Vignuzzi M, Denison MR. Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelity. J Virol. 2015;89:6418-26.

 

Milanesi E, Hadar A, Maffioletti E, Werner H, Shomron N, Gennarelli M, Schulze TG, Costa M, Del Zompo M, Squassina A, Gurwitz D. Insulin-like growth factor 1 differentially affects lithium sensitivity of lymphoblastoid cell lines from lithium responder and non-responder bipolar disorder patients. J Mol Neurosci. 2015;56:681-7.

 

Farberov L, Herzig E, Modai S, Isakov O, Hizi A, Shomron N. MicroRNA-mediated regulation of p21 and TASK1 cellular restriction factors enhances HIV-1 infection. J Cell Sci. 2015;128:1607-16.

 

Isakov O, Bordería AV, Golan D, Hamenahem A, Celniker G, Yoffe L, Blanc H, Vignuzzi M, Shomron N. Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum. Bioinformatics. 2015;31:2141- 50.

 

Hershkovitz-Rokah O, Modai S, Pasmanik-Chor M, Toren A, Shomron N, Raanani P, Shpilberg O, Granot G. Restoration of miR-424 suppresses BCRABL activity and sensitizes CML cells to imatinib treatment. Cancer Lett. 2015;360:245-56.

 

Isakov O, Lev D, Blumkin L, Celniker G, Leshinsky- Silver E, Shomron N. Crowdfunding effort identifies the causative mutation in a patient with nystagmus, microcephaly, dystonia and hypomyelination. J Genet Genomics. 2015;42:79-81.

 

Ninio-Many L, Grossman H, Levi M, Zilber S, Tsarfaty I, Shomron N, Tuvar A, Chuderland D, Stemmer SM, Ben-Aharon I, Shalgi R. MicroRNA miR-125a- 3p modulates molecular pathway of motility and migration in prostate cancer cells. Oncoscience. 2014;1:250-61.

 

Pérez R, Calleros L, Marandino A, Sarute N, Iraola G, Grecco S, Blanc H, Vignuzzi M, Isakov O, Shomron N, Carrau L, Hernández M, Francia L, Sosa K, Tomás G, Panzera Y. Phylogenetic and genome-wide deep-sequencing analyses of canine parvovirus reveal co-infection with field variants and emergence of a recent recombinant strain. PLoS One. 2014; 9:e111779.

 

Hershkovitz-Rokah O, Modai S, Pasmanik-Chor M, Toren A, Shomron N, Raanani P, Shpilberg O, Granot G. MiR-30e induces apoptosis and sensitizes K562 cells to imatinib treatment via regulation of the BCR-ABL protein. Cancer Lett. 2014; 356(2 Pt B):597-60.

 

Rudnicki A, Isakov O, Ushakov K, Shivatzki S, Weiss I, Friedman LM, Shomron N, Avraham KB. Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways. BMC Genomics. 2014;15:484.

 

Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, et al. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol. 2014;15:R53.

 

Stapleford KA, Coffey LL, Lay S, Bordería AV, Duong V, Isakov O, Rozen-Gagnon K, Arias-Goeta C, Blanc H, Beaucourt S, Haliloğlu T, Schmitt C, Bonne I, Ben-Tal N, Shomron N, Failloux AB, Buchy P, Vignuzzi M. Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential. Cell Host Microbe. 2014;15:706-16.

 

Mor E, He L, Torchinsky A, Shomron N. MicroRNA-34a is dispensable for p53 function as teratogenesis inducer. Arch Toxicol. 2014;88:1749-63.

 

Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le VT,  Galun E, Horejsi V, Isakov O, Shomron N, Wolf DG, Hengel H, Mandelboim O. MicroRNA Editing Facilitates Immune Elimination of HCMV Infected Cells. PLoS Pathog. 2014, 10:e1003963.

 

Agranat-Tamir L, Shomron N, Sperling J, Sperling R. Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome. Nucleic Acids Res. 2014 Jan 24.

 

Lustig Y, Barhod E, Ashwal-Fluss R, Gordin R, Shomron N, Baruch-Umansky K, Hemi R, Karasik A, Kanety H. RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling. Diabetes. 2014; 63:433-45.

 

Feinberg-Gorenshtein G, Guedj A, Shichrur K, Jeison M, Luria D, Kodman Y, Ash S, Feinmesser M, Edry L, Shomron N, Weizman A, Yaniv I, Avigad S. MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma. PLoS One. 2013, 8:e78713.

 

Oved K, Morag A, Pasmanik-Chor M, Rehavi M, Shomron N*, Gurwitz D*. Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants. Transl Psychiatry. 2013; 3:e313. * Equal corresponding

 

Eytan O, Morice-Picard F, Sarig O, Ezzedine K, Isakov O, Li Q, Ishida-Yamamoto A, Shomron N, Goldsmith T, Fuchs-Telem D, Adir N, Uitto J, Orlow SJ, Taieb A, Sprecher E. Cole Disease Results from Mutations in ENPP1. Am J Hum Genet. 2013; 93:752-7.

 

Isakov O, Rinella ES, Olchovsky D, Shimon I, Ostrer H, Shomron N, Friedman E.  Missense mutation in the MEN1 gene discovered through whole exome sequencing co-segregates with familial hyperparathyroidism. Genet Res (Camb). 2013; 95:114-20.

 

Barak B, Shvarts-Serebro I, Modai S, Gilam A, Okun E, Michaelson DM, Mattson MP, Shomron N, Ashery U. Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Transl Psychiatry. 2013; 3:e304.

 

Samuelov L, Sarig O, Harmon RM, Rapaport D, Ishida-Yamamoto A, Isakov O, Koetsier JL, Gat A, Goldberg I, Bergman R, Spiegel R, Eytan O, Geller S, Peleg S, Shomron N, Goh CS, Wilson NJ, Smith FJ, Pohler E, Simpson MA, McLean WH, Irvine AD, Horowitz M, McGrath JA, Green KJ, Sprecher E. Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. Nat Genet. 2013; 45, 1244–1248.

 

Ninio-Many L, Grossman H, Shomron N, Chuderland D, Shalgi R. microRNA-125a-3p reduces cell proliferation and migration by targeting Fyn. J Cell Sci. 2013; 126(Pt 13): 2867-76.

 

Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D, Laitman Y, Barshack I, Friedman E, Shomron N. Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers. Breast Cancer Res Treat. 2013; 138:753-60.

 

Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N. MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Neurobiol Dis. 2013; 55:1-10.

 

Shaham O, Gueta K, Mor E, Oren-Giladi P, Grinberg D, Xie Q, Cvekl A, Shomron N, Davis N, Keydar-Prizant M, Raviv S, Pasmanik-Chor M, Bell RE, Levy C, Avellino R, Banfi S, Conte I, Ashery-Padan R. Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet. 2013; 9:3.

 

Rukov JL, Wilentzik R, Jaffe I, Vinther J, Shomron N. Pharmaco-miR: linking microRNAs and drug effects. Brief Bioinform. 2013; Advance Access 10.1093/bib/bbs082.

 

Vincent M, Oved K, Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, Gurwitz D. Genome-wide transcriptomic variations of human lymphoblastoid cell lines: insights from pairwise gene-expression correlations. Pharmacogenomics. 2012; 13:1893-904.

 

Oved K, Morag A, Pasmanik-Chor M, Oron-Karni V, Shomron N, Rehavi M, Stingl JC, Gurwitz D. Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers. Pharmacogenomics. 2012;13:1129-39.

 

Buda I, Bachar G, Gilam A, Modai S, Strenov Y, Pasmanik-Chor M, Feinmesser R, Shomron N. Differential expression of microRNAs between aggressive and non-aggressive papillary thyroid carcinoma. Head Neck Oncol. 2012 Sep 9.Carmel I, Shomron N, Heifetz Y. Does base-pairing strength play a role in microRNA repression? RNA 2012; 18:1947-56.

 

Ben-Zvi S, Givati A, Shomron N. GenomeGems: evaluation of genetic variability from deep sequencing data. BMC Res Notes. 2012; 5:338.

 

Meshesha MK, Veksler-Lublinsky I, Isakov O, Reichenstein I, Shomron N, Kedem K, Ziv-Ukelson M, Bentwich Z, Avni YS. The microRNA transcriptome of human cytomegalovirus (HCMV). Open Virol J. 2012; 6:38-48.

 

Neuman JA, Isakov O, Shomron N. Analysis of insertion-deletion from deep-sequencing data: software evaluation for optimal detection. Brief Bioinform. 2013; 14:46-55.

 

Fuchs-Telem D, Sarig O, van Steensel MA, Isakov O, Israeli S, Nousbeck J, Richard K, Winnepenninckx V, Vernooij M, Shomron N, Uitto J, Fleckman P, Richard G, Sprecher E. Familial Pityriasis Rubra Pilaris is caused by mutations in CARD14. Am J Hum Genet. 2012; 91:163-170.

 

Grinberg M, Gilad S, Meiri E, Levy A, Isakov O, Ronen R, Shomron N, Bentwich Z, Shemer-Avni Y. Vaccinia virus infection suppresses the cell microRNA machinery. Arch Virol. 2012; 157:1719-1727.

 

Rokah OH, Granot G, Ovcharenko A, Modai S, Pasmanik-Chor M, Toren A, Shomron N, Shpilberg O. Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells. PLoS One. 2012; 7:e35501.

 

Alon S, Mor E, Vigneault F, Church GM, Locatelli F, Galeano F, Gallo A, Shomron N, Eisenberg E. Systematic identification of edited microRNAs in the human brain. Genome Res. 2012;22:1533-1540.

 

Isakov O, Ronen R, Kovarsky J, Gabay A, Gan I, Modai S, Shomron N. Novel insight into the non-coding repertoire through deep sequencing analysis. Nucleic Acids Res. 2012;40:e86.

 

Pando R, Even-Zohar N, Shtaif B, Edry L, Shomron N, Phillip M, Gat-Yablonski G. MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1. J Nutr Biochem. 2012, 23:1474-81.

 

Shichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012; 33:3586-93.

 

Kiezun A, Artzi S, Modai S, Volk N, Isakov O, Shomron N. miRviewer: a multispecies microRNA homologous viewer. BMC Res Notes. 2012; 5:92.

 

Sarfstein R, Pasmanik-Chor M, Yeheskel A, Edry L, Shomron N, Warman N, Wertheimer E, Maor S, Shochat L, Werner H. Insulin-like growth factor-I receptor  (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells. J Biol Chem. 2012; 287:2766-76.

 

Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD. Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 2011; 7:e1002330.

 

Brownstein Z*, Friedman LM*, Shahin H, Oron-Karni V, Kol N, Abu Rayyan A, Parzefall T, Lev D, Shalev S, Frydman M, Davidov B, Shohat M, Rahile M, Lieberman S, Levy-Lahad E, Lee M, Shomron N, King M-C, Walsh T, Kanaan M, Avraham KB. Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families. Genome Biol. 2011; 12: R89.

 

Isakov O, Modai S, Shomron N. Pathogen detection using short-RNA deep sequencing subtraction and assembly. Bioinformatics. 2011; 27:2027-30.

 

Volk N, Shomron N. Versatility of MicroRNA Biogenesis. PLoS One. 2011;6:e19391.

 

Greenberg E, Hershkovitz L, Itzhaki O, Hajdu S, Nemlich Y, Ortenberg R, Gefen N, Edry L, Modai S, Keisari Y, Besser MJ, Schachter J, Shomron N, Markel G. Regulation of cancer aggressive features in melanoma cells by microRNAs. PLoS One. 2011; 6:e18936.

 

Rukov JL, Vinther J, Shomron N. Pharmacogenomics genes show varying perceptibility to microRNA regulation. Pharmacogenet Genomics. 2011; 21:251-62

 

Mor E, Cabilly Y, Goldshmit Y, Zalts H, Modai S, Edry L, Elroy-Stein O, Shomron N. Species-specific microRNA roles elucidated following astrocyte activation. Nucleic Acids Res. 2011; 39:3710-23.

 

Ronen R, Gan I, Modai S, Sukacheov A, Dror G, Halperin E, Shomron N. miRNAkey: a software for microRNA deep sequencing analysis. Bioinformatics. 2010; 26:2615-6.

 

Shomron N, Hamasaki-Katagiri N, Hunt R, Hershko K, Pommier E, Geetha S, Blaisdell A, Dobkin A, Marple A, Roma I, Newell J, Allen C, Friedman S, Kimchi-Sarfaty C. A splice variant of ADAMTS13 is expressed in human hepatic stellate cells and cancerous tissues. Thromb Haemost. 2010;10:531-5. Erratum in: Thromb Haemost. 2010; 104:861

 

Golan D, Levy C, Friedman B, Shomron N. Biased hosting of intronic microRNA genes. Bioinformatics. 2010; 26:992-5.

 

Gueta K, Molotski N, Gerchikov N, Mor E, Savion S, Fein A, Toder V, Shomron N, Torchinsky A. Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype. BMC Dev Biol. 2010; 10:20.

 

Gefen N, Binder V, Zaliova M, Linka Y, Morrow M, Novosel A, Edry L, Hertzberg L, Shomron N, Williams O, Trka J, Borkhardt A, Izraeli S. Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53. Leukemia. 2010; 24:89-96

 

 

Reviews (Selected)

Pillar N, Yoffe L, Hod M, Shomron N. The possible involvement of microRNAs in preeclampsia and gestational diabetes mellitus. Best Pract Res Clin Obstet Gynaecol. 2014 Aug 21. pii: S1521-6934(14)00169-2.

 

Pillar N, Isakov O, Shomron N. Sequencing your genome: your future is here, but are you sure you want to know it? Genet Res (Camb). 2014 Jan;96:e006.

 

Shomron N. Genetics research: jumping into the deep end of the pool. Genet Res (Camb). 2013; 95:1-3.

 

Mor E, Shomron N. Species-specific microRNA regulation influences phenotypic variability: Perspectives on species-specific microRNA regulation. Bioessays. 2013 35:881-8.

 

Shomron N. A personal perspective on personalized medicine. Genet Res (Camb). 2013; 95:51.

 

Isakov O, Perrone M, Shomron N. Exome sequencing analysis: a guide to disease variant detection. Methods Mol Biol. 2013; 1038:137-58.

 

Kol N, Shomron N. Assembly algorithms for deep sequencing data: basics and pitfalls. Methods Mol Biol. 2013; 1038:81-91.

 

Rukov JL, Shomron N. MicroRNA pharmacogenomics: Post-transcriptional regulation of drug response. Trends Mol Med. 2011; 17:412-423.

 

Shomron N. MicroRNAs and developmental robustness: a new layer is revealed. PLoS Biol. 2010; 8:e1000397.

 

Shomron N. MicroRNAs and pharmacogenomics. Pharmacogenomics. 2010; 11:629-32. 

 

Grants

Grants (Selected)

2011-2016       I-CORE Program of the Planning and Budgeting Committee, The Israel Science Foundation (grant number 41/11)

2013-2016       Israel Cancer Research Fund (ICRF), Research Career Development Award (RCDA)

2014-2015       Earlier.org—Friends for an Earlier Breast Cancer Test

2014-2016       Israeli Ministry of Defence, office of Assistant Minister of Defence for Chemical, Biological, Radiological and Nuclear (CBRN) Defence

2014-2016       Saban Family Foundation—Melanoma Research Alliance

2014-2016       Foundation Fighting Blindness

2014-2016       Israel Cancer Research Fund (ICRF), Acceleration Grant

2014-2016       Binational Science Foundation (BSF)

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