Senior Lecturer (Assistant Professor), Sackler Faculty of Medicine
Dr. Chen Luxenburg
Dr. Luxenburg completed his Ph.D. studies at the Weizmann Institute of Science under the supervision of Profs. Lia Addadi and Benny Geiger, where he studied molecular and structural mechanisms of osteoclast adhesion. For his post-doctoral training, he moved to the laboratory of Prof. Elaine Fuchs at Rockefeller University in New York, where he studied the roles of the actin cytoskeleton in epidermal development. In October 2013 he returned to Israel and opened his independent research group. Luxenburg is a member of the Israeli Center of Research Excellence (I-CORE) “Gene Regulation in Complex Human Disease.”
Cytoskeletal Regulation of Epidermal Stem Cells
Our laboratory studies how cytoskeleton-derived signals control stem cell’s ability to give rise to a functional tissue during development, to maintain it throughout life and repair it upon wounding.
The actomyosin cytoskeleton is a complex cellular structure that plays a role in many biological processes. Classic studies established its role in cell structural organization. However, new studies demonstrate that the cytoskeleton plays a major role in regulatory processes that control signal transduction, gene expression and stem cell lineage specification.
Our laboratory uses the skin epidermis as its main model system. Projects in the lab explore both skin development and skin common diseases such as cancer and psoriasis. In addition to classic genetic tools and in vivo models we also use state of the art technology to manipulate stem cells in utero. Genome wide analysis of gene expression, quantitative digital microscopy and a variety of molecular and cellular methods are all commonly used in our lab.
Luxenburg C, and Zaidel-Bar R. (2019) “From cell shape to cell fate via the cytoskeleton — insights from the epidermis.” Exp. Cell Res. (in press)
Cohen J, Raviv S, Adir O, Padmanabhan K, Soffer A, and Luxenburg C. (2019) “The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt–Sox9 signaling.” J. Cell Biol. (In press)
Bhattacharya S, Serror L, Nir E, Dhiraj D, Altshuler A, Khreish M, Tiosano B, Hasson P, Panman L, Luxenburg C, Aberdam D, Shalom-Feuerstein R. (2019) “SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium.” Stem Cells. 2019 Mar;37(3):417-429.
Dor-On E, Raviv S, Cohen Y, Adir O, Padmanabhan K, Luxenburg C. (2017) "T-plastin is essential for basement membrane assembly and epidermal morphogenesis" Science Signaling. 2017 May 30;10(481). pii: eaal3154.
Luxenburg C and Geiger B. (2017) “Multiscale view of cytoskeletal mechanoregulation of cell and tissue polarity” Handb Exp Pharmacol. 235:263-284
Peled A, Sarig O, Samuelov L, Bertolini M, Ziv L, Weissglas-Volkov D, Eskin-Schwartz M, Adase CA, Malchin N, Bochner R, Fainberg G, Goldberg I, Sugawara K, Baniel A, Tsuruta D, Luxenburg C, Adir N, Duverger O, Morasso M, Shalev S, Gallo RL, Shomron N, Paus R, Sprecher E. (2016) “Mutations in TSPEAR, encoding a regulator of Notch signaling, affect tooth and hair follicle morphogenesis” PLoS Genet 13;12(10):e1006369.
Zaidel-Bar R, Zhenhuan G, and Luxenburg C. (2015) “The contractome: a systems view of actomyosin contractility in non-muscle cells” J. Cell Sci. 15;128(12):2209-17
Luxenburg C, Heller E, Pasolli HA, Chai S, Stokes N, and Fuchs E. (2015) “WDR1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity” Nature Cell Biol. 17(5):592-604
Luxenburg C, Pasolli HA, Williams SE, and Fuchs E. (2011) “Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation” Nature Cell Biol. 13(3):203-14