Dr. Lihi Abramovich

  • סגל אקדמי בכיר in School of Dentistry
ביה"ס לרפואת שינים סגל אקדמי בכיר
Dr. Lihi Abramovich
Phone: 03-6407252
Another phone: 03-6409309
Office: School of Dental Medicine, 044

Positions

Senior Lecturer, Sackler Faculty of Medicine

Affiliated, TAU Center for Nanoscience and Nanotechnology

Laboratory of Bioinspired Materials

Research in my Laboratory of Bioinspired Materials is focused on mimicking self-assembly processes that occur in nature, including biomineralization and the organization of short peptides and amino acids into ordered nanostructures. We are a material science laboratory with emphasize on organic chemistry and medical-biological applications. The group is developing new organic materials that are used for various applications, such as 3D hydrogels for bone tissue regeneration, which exhibit extraordinary mechanical properties and durability, along with biocompatibility and controlled drugs release. A central technique is the formation of hybrid hydrogels, using two or more different building blocks, resulting in a 3D hydrogel with novel and diverse properties that can be easily fine-tuned. In addition, the laboratory is interested in antimicrobial activity of nanostructures for coatings and incorporation into composite materials for dental medicine application.

Publications

  1. Berger, O., Yoskovitz, E., Adler-Abramovich, L., Gazit, E. Spectral transition in bio-inspired self-assembled peptide nucleic acid photonic crystals. Adv. Mater.; 2016.
  2. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt, J., Kesselman, E., Shimon, L. J.W., Ramamoorthy, A., Talmon, Y., Gazit, E. Spontaneous structural transition and crystal formation in minimal supramolecular polymer model. Sci. Adv.2016.
  3. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, T., Ebenstein, Y., Frolow, F., Shimon, L. J. W., Patolsky, F., Gazit, E. Light-emitting self-Assembled peptide nucleic acids exhibit both stacking and Watson-Crick base-pairing. Nature Nanotechnol.; 2015: 10: 353-360.
  4. Mondal, S.*, Adler-Abramovich, L.*, Lampel, A., Bram, Y., Lipstman, S., Gazit, E. Formation of functional super-helical assemblies by constrained single heptad repeat. Nature Commun.; 2015: 68615.
  5. Pellach M., Atsmon-Raz Y., Simonovsky E., Gottlieb H., Jacoby G., Beck R., Adler-Abramovich, L., Miller Y., Gazit E. Spontaneous structural transition in phospholipid-inspired aromatic phosphopeptide nanostructures. ACS Nano; 2015: 9: 4085-4095.
  6. Tao, K., Adler-Abramovich, L., Gazit, E. Controllable Phase Separation by Boc-modified lipophilic acid as a multifunctional extractant. Sci. Rep.; 2015: 5, 17509
  7. De Luigi, A., Mariani, A., De Paola, M., Re Depaolini, A., Colombo, L., Russo, L., Rondelli, V., Brocca, P., Adler-Abramovich, L., Gazit, E., Del Favero, E., Cantù, L., Salmona. M. Doxycycline hinders phenylalanine fibril assemblies revealing a potential novel therapeutic approach in phenylketonuria. Sci. Rep.; 2015: 5
  8. Arnon, Z., Adler-Abramovich, L., Levin, A., Gazit E. Solvent-induced self-assembly of highly hydrophobic tetra-and pentaphenylalanine peptides. Isr. J. Chem.; 2015: 5, 756-762. 5.
  9. Shaham-Niv, S., Adler-Abramovich, L., Schnaider, L., Gazit E. Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies. Sci. Adv.; 2015: 1, e1500137.
  10. Tao, K., Yoskovitz, E., Adler-Abramovich, L., Gazit, E. Optical property modulation of Fmoc group by pH-dependent self-assembly. RSC Advances; 2015: 5, 73914-73918.
  11. Fichman, G., Guterman, T., Adler-Abramovich, L., Gazit, E. Synergetic functional properties of two-component single amino acid-based hydrogels. CrystEngComm.; 2015: 17, 8105-8112.
  12. Ostrov, N., Fichman, G., Adler-Abramovich, L., Gazit, E. FtsZ Cytoskeletal filaments as a template for metallic nanowire fabrication. J. Nanosci. Nanotechnol.; 2015: 15, 556-561.
  13. Adler-Abramovich, L., Gazit, E. The physical properties of supramolecular peptide assemblies: from building block association to technological applications. Chem. Soc. Rev.2014: 43, 6881-6893.
  14. Levin, A., Mason, T.O., Adler-Abramovich, L., Buell, A. K., Meisl, G., Galvagnion, C. Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers. Nature Commun.; 2014: 5, 5219.
  15. Fichman, G., Guterman, T., Adler-Abramovich, L., Gazit, E. The use of the calcitonin minimal recognition module for the design of DOPA-containing fibrillar assemblies. Nanomaterials; 2014: 4, 726-740.
  16. Fichman, G., Adler-Abramovich, L., Manohar, S., Mironi-Harpaz, I., Guterman, T. Seliktar, D., Messersmith, P.B., Gazit, E. Seamless metallic coating and surface adhesion of self-assembled bio-inspired nanostructures based on di-(3, 4-dihydroxy-L-phenylalanine) peptide motif. ACS Nano2014: 22, 7220-7228.
  17. Mossou, E., Teixeira, S.C.M., Mitchell, E.P., Mason, S.A., Adler-Abramovich, L., Gazit, E., Forsyth, V.T. The self-assembling zwitterionic form of L-phenylalanine at neutral pH. Acta Crystallogr., Sect. C.2014: 70, 326-331.
  18. Mason, T.O., Chirgadze, D.Y., Levin, A., Adler-Abramovich, L., Gazit, E., Knowles, T.P.J., Buell, A.K. Expanding the solvent chemical space for self-assembly of dipeptide nanostructures. ACS Nano; 2014: 8, 1243-1253.
  19. Azuri, I., Adler-Abramovich, L., Gazit, E., Hod, O., Kronik, L. Why are diphenylalanine-based peptide nanostructures so rigid? Insights from first principles calculations. J. Am. Chem. Soc.2014: 136, 963-969.
  20. Kaur, G., Adler-Abramovich, L., Gazit, E., Verma, S. Ultrastructure of metallopeptide-based soft spherical morphologies. R. Soc. Chem. Adv.; 2014: 4, 64457-64465.
  21. Ischakov, R., Adler-Abramovich, L., Buzhansky, L., Shekhter, T., Gazit, E. Peptide-based hydrogel nanoparticles as effective drug delivery agents. Bioorg. Med. Chem.2013: 21, 3517-3522.
  22. Ghosh, S., Adler-Abramovich, L., Gazit, E., Verma, S. Spacer driven morphological twist in Phe-Phe dipeptide conjugates. Tetrahedron; 2013: 69, 2004-2009.
  23. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Mango, A., Caflish, A., Frenkel, D., Gazit, E. Phenylalanine self-assembles into ordered toxic fibrils at phenylketonuria pathological concentration. Nature Chem. Biol.; 2012: 8, 701-706.
  24. Goldshtein, K.,  Golodnitsky, D., Peled, E., Adler-Abramovich, L., Gazit, E., Khatun, S., Stallworth, P., Greenbaum, S. Effect of peptide nanotube filler on structural and ion-transport properties of solid polymer electrolytes. Solid State Ion.; 2012: 220, 39-46.
  25. Roytman, R.*, Adler-Abramovich, L*, Kumar, K.S., Kuan, T.C., Lin, C.C., Gazit, E., Brik, A. Exploring the self-assembly of glycopeptides using a diphenylalanine scaffold. Org. Biomol. Chem.; 2011: 9, 5755-5761.
  26. Even N., Adler-Abramovich L., Buzhansky L., Dodiuk H. and Gazit E. Improvement of the mechanical properties of epoxy by peptide nanotube fillers. Small; 2011: 7, 1007-1011.
  27. Santhanamoorthi, N., Kolandaivel, P., Adler-Abramovich, L., Gazit, E., Filipek, S., Sowmya, V., Strzelczyk, A., Renugopalakrishnan, V. Diphenylalanine peptide nanotube: charge transport, band gap and its relevance to potential biomedical applications Adv. Mat. Lett.; 2011: 2, 100-105.
  28. Adler-Abramovich, L., and Gazit, E. Nanotubes and Nanowires, Self-assembled peptide nanostructures. Handbook of nanophysics; 2010: Vol. 4: Chapter 15.
  29. Orbach, R., Mironi-Harpaz, I., Adler-Abramovich, L., Mossou, E., Forsyth, T.V., Gazit, E., Seliktar, D. The rheological and structural properties of Fmoc-peptide-based hydrogels: The effect of aromatic molecular architecture on self-assembly and physical characteristics. Langmuir; 2010: 28, 2015-2022.
  30. Adler-Abramovich, L., Kol, N., Yanai, I., Barlam, D., Shneck Z.R., Gazit, E., Rousso, I. Self-assembled organic nanostructures with metallic-like tensile strength. Angew. Chem. Int. Ed.; 2010: 49, 9939-9942
  31. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E., Rishpon, J. Characterization of peptide nanostructures modified electrodes and their application in ultra-sensitive environmental monitoring. Small; 2010: 7, 825-831.
  32. Adler-Abramovich, L., Aronov, D., Beker, P., Yevnin, M., Stempler, S., Buzhansky, L., Rosenman, Gazit, E. Self-assembled arrays of peptide nanotubes by vapour deposition. Nature Nanotechnol.; 2009: 4, 849-854.
  33. Orbach, R., Adler-Abramovich, L., Zigerson, S., Mironi-Harpaz, I., Seliktar, D., Gazit, E. Self-assembled Fmoc-peptides as a platform for the formation of nanostructures and hydrogelsBiomacromolecules; 2009: 10, 2646-2651.
  34. Amdursky N, Molotskii M, Aronov D, Adler-Abramovich L, Gazit E, Rosenman G. Blue luminescence based on quantum confinement at peptide nanotubes. Nano Lett.; 2009: 9, 3111-3115.
  35. Tamamis, P.*, Adler-Abramovich, L.*, Reches, M., Marshall, K., Sikorski, P., Serpell, L., Gazit., E., Archontis, G. Self-assembly of phenylalanine oligopeptides: Insights from experiments and molecular dynamics simulations in implicit solvent. Biophys. J.; 2009: 96, 5020-5029.
  36. Adler-Abramovich, L., Aronov, D., Rosenman, G., Gazit, E. Patterned arrays of ordered peptide nanostructures. J. Nanosci. Nanotechnol.; 2009: 9, 1701-1708.
  37. Kasotakis, E., Mossou, E., Adler-Abramovich, L., Forsyth, T., Gazit E., Mitraki, A. Design of metal binding sites onto self-assembling peptide fibril scaffolds. Biopolymers; 2009: 92, 164-172.
  38. Adler-Abramovich, L., and Gazit, E. Controlled patterning of peptide nanotubes and nanospheres using inkjet printing technology. J. Pep. Sci.; 2008: 14, 217-223.
  39. Hill R. J. A., Sedman V. L., Allen S., Williams P., Paoli M., Adler-Abramovich L., Gazit E., Eaves L., Tendler S.J.B. Alignment of aromatic peptide tubes in strong magnetic fields. Adv. Mater.; 2007: 19, 4474-4479.
  40. Adler-Abramovich L., Perry R., Sagi A., Gazit E., Shabat D. Controlled assembly of peptide nanotubes triggered by enzymatic activation of self-immolative dendrimers. ChemBioChem.; 2007: 8, 859-862.
  41. Sedman, V.L., Adler-Abramovich, L., Allen, S., Gazit, E., Tendler, S.J.B. Direct observation of the release of phenylalanine from diphenylalanine nanotubes. J. Am. Chem. Soc.; 2006: 128, 6903-6908.
  42. Adler-Abramovich, L., Reches, M., Sedman, V.L., Tendler, S.J.B., Gazit, E. Notable thermal and chemical stability of diphenylalanine peptide nanotubes: Implications for nanotechnological applicationsLangmuir; 2006: 22, 1313-1320.
  43. Kol, N.*, Adler-Abramovich, L.*, Barlam, D., Shneck Z.R., Gazit, E., Rousso, I. Self-assembled peptide nanotubes are uniquely rigid bioinspired supramolecular structures. Nano Lett.; 2005: 5, 1343-1346.
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