Prof. Lihi Abramovich

 Professor, Department of Oral Biology, The Goldschleger School of Dental Medicine

​Head, Laboratory of Bioinspired Materials & Nanotechnology

TAU Center for Nanoscience and Nanotechnology

Research in my Laboratory of Bioinspired Materials is focused on mimicking self-assembly processes that occur in nature, including biomineralization and the organization of short peptides and amino acids into ordered nanostructures. We are a material science laboratory with emphasize on organic chemistry and medical-biological applications. The group is developing new organic materials that are used for various applications, such as 3D hydrogels for bone tissue regeneration, which exhibit extraordinary mechanical properties and durability, along with biocompatibility and controlled drugs release. A central technique is the formation of hybrid hydrogels, using two or more different building blocks, resulting in a 3D hydrogel with novel and diverse properties that can be easily fine-tuned. In addition, the laboratory is interested in antimicrobial activity of nanostructures for coatings and incorporation into composite materials for dental medicine application.

Full publication list in Google Scholar

Selected Publication 

1. Aviv, M., Halperin-Sternfeld, M., Grigoriants, I., Buzhansky, L., Mironi-Harpaz, I., Seliktar, D., Einav, S., Nevo, Z., Adler-Abramovich, L. (2018) Improving the Mechanical Rigidity of Hyaluronic Acid by Integration of Supramolecular Peptide Matrix. ACS Appl. Mater. Interfaces, 10, 41883-41891.
2. Halperin-Sternfeld, M., Ghosh, M., Sevostianov, R., Grogoriants, I., Adler-Abramovich, L. (2017) Molecular Co-Assembly as a Strategy for Synergistic Improvement of the Mechanical Properties of Hydrogels. Chem. Comm. 53, 9586-9589.
3. Ghosh, M., Halperin-Sternfeld, M., Grigoriants, I., Lee, J., Nam, K. T., Adler-Abramovich, L. (2017). Arginine-presenting peptide hydrogels decorated with hydroxyapatite as biomimetic scaffolds for bone regeneration. Biomacromolecules 18, 3541–3550.
4. Roth-Konforti, M.E, Comune, M., Halperin-Sternfeld, M., Grigoriants, I., Shabat, D., Adler-Abramovich, L. (2018) UV Light–Responsive Peptide-Based Supramolecular Hydrogel for Controlled Drug Delivery. Macromol. Rapid Commun. 39, 1800588.
5. Ghosh, M., Halperin-Sternfeld, M., Grinberg, I., Adler-Abramovich, L. (2019). Injectable Alginate-Peptide Composite Hydrogel as a Scaffold for Bone Tissue Regeneration. Nanomaterials 9, 497.
6. Brahmachari, S., Arnon, Z. A., Frydman-Marom, A., Gazit, E., Adler-Abramovich, L. (2017) Diphenylalanine as a Reductionist Model for the Mechanistic Characterization of β-Amyloid Modulators. ACS Nano 11, 5960–5969.
7. Schnaider, L., Ghosh, M., Bychenko, D., Grigoriants, I., Ya’ari, S., Shalev Antsel, T., Matalon, S., Sarig, R., Brosh, T, Pilo, R, Gazit, E., Adler-Abramovich, L. (2019) Enhanced Nanoassembly-Incorporated Antibacterial Composite Materials. ACS Applied Materials & Interfaces 11, 21334-21342.
8. Adler-Abramovich, L., Arnon, Z. A., Sui, X., Azuri, I., Cohen, H., (2017). Bioinspired Flexible and Tough Layered Peptide Crystals. Adv. Mater., 30, 1704551. Selected for the cover of the journal.  
9. Arnon, Z.A., Vitalis, A., Levin, A., Michaels, T.C.T., Caflisch, A., Knowles, T.P.J., Adler-Abramovich, L.*, Gazit, E.* (2016) Dynamic microfluidic control of supramolecular peptide self-assembly. Nature Commun. 7, 13190. *Both senior corresponding authors.
10. Adler-Abramovich, L., Marco, P., Arnon, Z.A., Creasey, Michaels, T.C.T., Levin, A., Scurr, D.J., Roberts C.J., Knowles, T. P. J., Tendler, S.J.B. Gazit, E. (2016) Controlling the Physical Dimensions of Peptide Nanotube by Supramolecular Polymer Co-assembly. ACS Nano 10, 7436–7442.
11. Berger, O. Adler-Abramovich, L. Levy-Sakin, M. Grunwald, A. Bachar, M. Buzhansky, L. Mossou, E. Forsyth, T. Ebenstein, Y. Frolow, F. Shimon, L.J.W. Patolsky, F. Gazit, E. (2015) Light emitting self-Assembled peptide nucleic acids exhibit both stacking and watson-crick base-pairing. Nature Nanotechnol. 10, 353-360. Selected for the cover of the journal.
12. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Mango, A., Caflish, A., Frenkel, D., Gazit, E. (2012) Phenylalanine self-assembles into ordered toxic fibrils at phenylketonuria pathological concentration. Nature Chem. Biol. 8, 701-706.
13. Adler-Abramovich, L., Kol, N., Yanai, I., Barlam, D., Shneck Z.R., Gazit, E., Rousso, I. (2010) Self-assembled organic nanostructures with metallic-like tensile strength. Angew. Chem. Int. Ed. 49, 9939-9942. Selected for the cover of the journal.
14. Adler-Abramovich, L.*, Aronov, D.*, Beker, P., Yevnin, M., Stempler, S., Buzhansky, L., Rosenman, Gazit, E. (2009) Self-assembled arrays of peptide nanotubes by vapour deposition. Nature Nanotechnol. 4, 849-854.