Prof. Silvia Koton

חוג לסיעוד-תכנית כללית סגל אקדמי בכיר
Prof. Silvia Koton
Phone: 03-6409660
Fax: 03-6409496
Office: Health Professions, 307


Associate Professor, Department of Nursing, School of Health Professions, Tel Aviv University

Chair, Department of Nursing, School of Health Professions, Tel Aviv University

Adjunct Associate Professor, Johns Hopkins Bloomberg School of Public Health



  Post Doctoral Fellowship: Stroke Prevention Research Unit John Radcliffe Hospital, Oxford, UK
1999 – 2003  Ph.D. in Epidemiology and Preventive Medicine Tel Aviv University
1992 – 1995   Master of Occupational and Environmental Health (M.Occ.H.) Tel Aviv University
1980 – 1984 Bachelor of Nursing Science (B.S.N.) and Registered Nurse (R.N.) The Hebrew University



Epidemiology of Cardiovascular Diseases

Our research focuses on the epidemiology of cardiovascular diseases with special interest in the epidemiology of stroke. During the last few years, our studies have covered diverse subjects including trends in stroke morbidity and mortality among different population groups, strategies for primary and secondary prevention of stroke, determinants of stroke outcomes and novel risk factors acting as long-term and immediate triggering factors. Taking advantage of our knowledge and skills in the environmemtal and occupational health fields, we also study the health effects of pollution among survivors of cardiovascular diseases.


Since the establishment of the ongoing triennial National Acute Stroke Israeli (NASIS) registry in 2004, I carry out nationwide studies in collaboration with specialists in neurology and stroke research. Theses studies are aimed at characterizing management and outcomes of acute stroke patients and are an important means for providing both clinicians and health policy makers with data required for optimizing prevention strategies and care of stroke patients in Israel.


Selected Publications

Koton S, Tanne D, MS. Green, Bornstein NM. Mortality and predictors of death one month and three years after first-ever ischemic stroke: data from the first National Acute Stroke Israeli Survey (NASIS 2004). Neuroepidemiology 2010;34:90-96 .

Schwammenthal Y, Bornstein MN, Schwammenthal E, Schwartz R, Goldbourt U, Tsabari R, Koton S, Grossman E, Tanne D. Relation of effective anticoagulation in patients with atrial fibrillation to stroke severity and survival (from the National Acute Stroke Israeli Survey [NASIS]).Am J Cardiol.2010;105:411-6.

 Koton S, Bornstein NM, Tsabari R, Tanne D; on behalf of the NASIS Investigators. Derivation and validation of the Prolonged Length of Stay (PLOS) score in acute stroke patients.Neurology 2010;1511-6.

Gerber Y, Myers V, Broday DM, Koton S, Steinberg DM, Drory Y. Cumulative exposure to air pollution and long term outcomes after first acute myocardial infarction: A population based cohort study. Objectives and methodology. BMC Public Health  2010,10:369.

Koton S, Luengo-Fernandez R, Metha Z, Rothwell PM. Independent validation of the Prolonged Length of Stay (PLOS) score. Neuroepidemiology  2010; 35:263-266.

Gerber Y, Koton S, Goldbourt U, Myers V, Benyamini Y, Tanne D, Drory Y; for the Israel Study Group on First Acute Myocardial Infarction. Poor neighbourhood socioeconomic status predicts long-term risk of ischemic stroke aftermyocardial infarction. Epidemiology2010; 22:162-169.

Schwammenthal Y, Bornstein NM, Goldbourt U, Koton S, Schwartz R, Koren-Morag N, Grossman E, Tanne D. Anticoagulation remains underused in prevention of stroke associated with atrial fibrillation: Insights from two consecutive national surveys. Int J Cardiol. 2011;152:356-361.

Koton S, Gerber Y, Goldbourt U, Drory Y; for the Israel Study Group on First Acute Myocardial Infarction. Socioeconomic risk factor aggregation and long-term stroke incidence in patients after a first acute myocardial infarction.Int J Cardiol.2012; 157:324-329.

Koton S,Tashlykov V,Molshatzki N, Merzeliak O, Schwammenthal Y,Toashi M, Orion D, Tsabari R, Tanne D.Cerebral artery calcification in patients with acute cerebrovascular diseases: Determinants and long-term clinical outcome. Eur J Neurol. 2012, 19:739-45.

Tanne D, Koton S, Molshazki N, Goldbourt U, Shohat T, Tsabari R, Grossman E, Bornstein NM, on behalf of the NASIS Investigators. Trends in Management and Outcome of Hospitalized Patients with Acute Stroke and TIA: The National Acute Stroke Israeli (NASIS) Registry. Stroke 2012,43:2136-41.

Gur AY, Tanne D, Bornstein NM, Milo R, Auriel E, Shopin L,Koton S. Stroke in the very elderly: Characteristics and predictors of outcome in patients aged ≥ 85 years with a first-ever ischemic stroke. Neuroepidemiology 2012;39:57-62.

Koton S, Tanne D, Bornstein NM, on behalf of the NASIS Investigators. Ischemic stroke on-awakening: Patients’ characteristics, outcomes and potential for reperfusion therapy.Neuroepidemiology 2012;39:149-153.

Dombe S, Barzilai B, Koton S, Tabak N. Variables influencing the attitudes of nurses toward euthanasia of severely damaged newborns and premature babies. Refuah ve-mishpat2012; 45:77-89 (in Hebrew).

Koton S, Molshatzki N, Bornstein NM, Tanne D. Low cholesterol, statins and outcomes in patients with first-ever acute ischemic stroke.Cerebrovasc Dis.2012


Paul NL, Koton S, Simoni M, Geraghty OC, Luengo-Fernandez R, Rothwell PM. Feasibility, safety and cost of outpatient management of acute minor ischaemic stroke: a population-based study. J Neurol Neurosurg Psychiatry. 2013; 84:356-61.


Koton S, Molshatzki N, Yuval, Myers V, Broday DM, Drory Y, Steinberg DM, Gerber Y. Cumulative exposure to particulate matter air pollution and longterm post-myocardial infarction outcomes. Prev Med. 2013: 57:339-44


Tanne D, Koton S, Bornstein NM. National stroke registries: what can we learn from them? Neurology. 2013; 81:1257-1259.


Koton S, Tsabari R, Molshazki N, Kushnir M, ShaienR, Eilam A, Tanne D; NASIS Investigators. Burden and outcome of prevalent ischemic brain disease in a national acute stroke registry. Stroke. 2013; 44:3293-3297.


Koton S, Telman G, Kimiagar I, Tanne D; NASIS Investigators. Gender differences in characteristics,management and outcome at discharge and three months after stroke in a national acute stroke registry. Int J Cardiol. 2013; 168:4081-4084.


Itzhaki M, Koton S. Knowledge, perceptions and thoughts of stroke among Arab-Muslim Israelis. Eur J Cardiovasc Nurs. 2014: 3:78-85


Cobb LK, McAdams-Demarco MA, Huxley RR, Woodward M, Koton S, Coresh J, Anderson CA. The association of spousal smoking status with the ability to quit smoking: the Atherosclerosis Risk in Communities study. Am J Epidemiol. 2014; 179:1182-1187.


Gerber Y, Myers V, Broday DM, Steinberg DM, Yuval, Koton S, Drory Y. Frailty status modifies the association between air pollution and postmyocardial infarction mortality: a 20-year follow-up study. J Am Coll Cardiol. 2014; 63:1698-1699.


Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
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