Prof. Rafi Korenstein

Emeritus in Physiology Pharmacology
פיזיולוגיה ופרמקולוגיה אמריטוס
Prof. Rafi Korenstein
Phone: 03-6406042
Fax: 03-6408982
Office: Sackler School of Medicine, 614


Professor Emeritus, Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University

Chair, Commission K of the Israel National Committee for Radio Science of Israel Academy of Sciences and Humanities on Electromagnetics in Biology and Medicine

Editorial Board, Bioelectromagnetics



Interaction of Nanomaterials and Electromagnetic Fields with Cells

Research activity addresses the following lines of research:

  • Adsorption and uptake of nanoparticles by cells in relation to drug delivery and toxicity
  • Enhancement of uptake by electrical and chemical means
  • Treatment of cancer by electrochemical based approach
  • Assessment of genetic and epigenetic risks following in-vitro exposure to electromagnetic fields associated with cell phone communication
  • Physiological regulation and underlying mechanism of cell membrane-cortical skeleton nanoscale mechanical fluctuations.

Research methods used include routine cell biology and biochemical methodologies with emphasis on special cutting edge light microscopies possessing nanometric resolution such as Digital Holographic Microscopy.




Bañares M.A., Haase A., Tran L., Lobaskin V., Oberdörster G., Rallo R., Leszczynski J., Hoet P., Korenstein R., Hardy B., and Puzyn T. (2017) CompNanoTox2015: novel perspectives from a European conference on computational nanotoxicology on predictive nanotoxicology. Nanotoxicology, DOI: 10.1080/17435390.2017.1371351. 


Maguire C.M., Sillence K., Roesslein M., (….) Korenstein R., Reidiker M., Wick P., Hole P., Prina-Mello A. (2017) Benchmark of nanoparticle tracking analysis on measuring nanoparticle sizing and concentration. Journal of Micro- and Nano-Manufacturing 5 / 041002-1. 


Oziel M., Korenstein R., and Rubinsky B. (2017) Radar based technology for non-contact monitoring of accumulation of blood in the head: A numerical study. PLoS ONE 12(10): e0186381.


Habaza, M., Kirschbaum, M., Guernth-Marschner, C., Dardikman, G., Barnea, I., Korenstein, R., Duschl, C., Shaked, N.T. (2016) Rapid 3D refractive-index imaging of live cells in suspension without labeling using dielectrophoretic cell rotation. Advanced Science 4(2),1600205.


Ophir N., Bar Shai A., Alkalay Y., Israeli S., Korenstein R., Kramer M.R., Fireman E. (2016) Artificial stone dust-induced functional and inflammatory abnormalities in exposed workers monitored quantitatively by biometrics. European Respiratory Journal Open Research, 2(1), 00086-2015


Toropova, A.P., Toropov, A.A., Benfenati, E., Korenstein, R., Leszczynska, D., Leszczynski, J. (2015) Optimal nano-descriptors as translators of eclectic data into prediction of the cell membrane damage by means of nano metal-oxides. Environ Sci Pollut Res Int 22, 745-757.


Turko, N.A., Barnea, I., Blum, O., Korenstein, R., Shaked, N.T. (2015) Detection and controlled depletion of cancer cells using photothermal phase microscopy. J Biophotonics 8, 755-763.


Ben-Dov, N. and Korenstein R. (2015) The uptake of HIV Tat peptide proceeds via two pathways which differ from macropinocytosis. Biochim Biophys Acta
1848, 869-877.


Keisari, Y., Hochman, I., Confino, H., Korenstein, R., Kelson, I. (2014) Activation of local and systemic anti-tumor immune responses by ablation of solid tumors with intratumoral electrochemical or alpha radiation treatments. Cancer Immunol Immunother 63,1-9


Madi L., Rosenberg-Haggen, B., Nyska, A., and Korenstein, R. (2013) Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants. Exp Dermatol 22, 74-77.


Hole P., Sillence K., Hannell C., Maguire CM Roesslein M, Suarez G, Capracotta S, Magdolenova Z, Horev-Azaria L, Dybowska A, Cooke L, Haase A, Contal S, Manø S, Vennemann A, Sauvain J-J, Staunton KC, Anguissola S, Luch A, Dusinska M, Korenstein R, Gutleb AC, Wiemann M, Prina-Mello A, Riediker M, Wick P., (2013) Interlaboratory comparison of size measurements on nanopartcles using Nanoparticle Tracking Analysis (NTA). J Nanopart Res 15, 2101.


Wolf-Goldberg T., Barbul, A., Ben-Dov N., Korenstein R. (2013) Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H+ and ROS concentrations. Biochim Biophys Acta 1833, 1396–1408


Ben-Dov N. and Korenstein R. (2013) Proton-induced endocytosis is dependent on cell membrane fluidity, lipid-phase order and the membrane resting potential. Biochim Biophys Acta 1828, 2672-2681


Ben-Dov N., and Korenstein R. (2013) Actin-cytoskeleton rearrangement modulates proton-induced uptake. Exp Cell Res. 319, 946-954.


Horev-Azaria L., Baldi G., Beno D., Bonacchi D, Golla-Schindler U, Kirkpatrick JC, Kolle S, Landsiedel R, Maimon O, Marche PN, Ponti J, Romano R, Rossi F, Sommer D, Uboldi C, Unger RE, Villiers C, Korenstein R. (2013) Predictive Toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data. Part Fibre Toxicol 10:32.


Goñi-de-Cerio F., Mariani V., Cohen D., Korenstein R. et al., (2013) Biocompatibility study of two di-block co-polymeric NPs for biomedical applications by in vitro toxicity testing. J Nanopart Res 15:2036


Ben-Dov N, Rozman Grinberg I, Korenstein R (2012) Electroendocytosis Is Driven by the Binding of Electrochemically Produced Protons to the Cell’s Surface. PLoS One 7: e50299


Shock, I., Barbul, A., Girshovitz, P. Nevo, U., Korenstein, R., Shaked N.T. (2012) Optical phase nanoscopy in red blood cells using low-coherence spectroscopy. J Biomed Optics 17, 101509


Ben-Dov N. and Korenstein R. (2012) Enhancement of cell membrane invaginations, vesiculation and uptake of macromolecules by protonation of the cell surface. PLoS One 7, E35204


Ben-Dov N. and Korenstein R. (2012) Cell-based detection of electrochemical oxidative stress by a fluorescent tryptophan intermediate. Bioelectrochem 84:11-17




Keisari Y. and Korenstein R. (2013) In-situ ablation of solid tumors by electric forces and its effect on the tumor microenvironment and anti-tumor immunity. In: Tumor Ablation: effects on systemic and local anti-tumor immunity and on other tumor-microenvironment interactions. Y. Keisari, Ed. Springer, Dordrecht, 2013, Ch. 8, pp. 133-153.



  • 2015-2018 European Commission – Horizon 2020 ERA-NET funded consortium on “Establishing nanomaterial grouping/classification strategies according to toxicity and biological effects for supporting risk assessment” (achronym “NanoToxClass”).
  • 2016-2019 European Commission – Horizon 2020 EC funded consortium on “High level Integrated Sensor for Nanotoxicity Screening (acronym “HISENTS”).


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