Professor Emerita of Clinical Biochemistry, Sackler Faculty of MedicineFormer Lily and Avraham Gildor Chair for the Investigation of Growth FactorsDirector, Dr. Diana and Zelman Elton Laboratory for Molecular NeuroendocrinologyEditor-in-Chief, Journal of Molecular NeuroscienceMember, The Council for Higher Education (CHE), IsraelChief Scientific Officer, Coronis NeuroscienceCouncil Member, European Society for NeurochemistryPresident Summer Neuropeptide Conference
Prof. Illana Gozes
Neuronal Plasticity and Nerve Cell Protection in Disease
Our research is characterized by a multi-level approach to the study of brain function, behavior, memory and drug discovery, from molecules to cures. Targeting autism, schizophrenia as well as Alzheimer’s disease and related neurodegeneration and utilizing a multidisciplinary approach, our group investigates different aspects of neuronal plasticity and nerve cell protection, at the molecular, cellular and system level.
A major focus in the laboratory is on nerve structure and transport mechanisms. We have discovered novel families of proteins associated with cross talk among nerve cells and their support cells, including activity-dependent neurotrophic factor (ADNF) and activity-dependent neuroprotetive proteins (ADNPs, with ADNP being a major gene mutated in autism). Small ADNF and ADNP derivatives are in clinical development. The lead compound, davunetide is planned for an advanced Phase II clinical trial with the biotech industry.
Davunetide has previously shown efficacy in several Phase II clinical trials (i.e. in patients suffering from mild cognitive impairment, preceding Alzheimer's disease and in schizophrenia patients, protecting activities of daily living).
Publications & Grants
87. I. Gozes. The cytoskeleton as a drug target for neuroprotection: the case of the autism-mutated ADNP. Biol Chem. 2016 Mar;397(3):177-84. http://www.ncbi.nlm.nih.gov/pubmed/2595528288. I. Gozes, C. Helsmoortel, G. Vandeweyer, N. Van der Aa, F. Kooy, S. Bedrosian Sermone. The Compassionate Side of Neuroscience: Tony Sermone Undiagnosed Genetic Journey—ADNP Mutation. J Mol Neurosci (2015) 56:751–757. DOI 10.1007/s12031-015-0586-6. http://www.ncbi.nlm.nih.gov/pubmed/2595528289. I. Gozes, P.W. Baas, C. Richter-Landsberg. International Meeting Molecular Neurodegeneration: News and Views in Molecular Neuroscience in Health and Disease. Delmenhorst, Germany, July 20–22, 2015. J Mol Neurosci. 2015 Oct;57(2):153-9. doi: 10.1007/s12031-015-0637-z. http://www.ncbi.nlm.nih.gov/pubmed/2631926590. I. Gozes, Y. Ivashko-Pachima, ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration. Front Aging Neurosci 2015, 7:205.http://www.ncbi.nlm.nih.gov/pubmed/2657895091. D.J. Klionsky, …I. Gozes (~1000 authors). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. http://www.ncbi.nlm.nih.gov/pubmed/2679965292. Pennuto M, I. Gozes. Introduction to the Special Issue on Spinal and Bulbar Muscular Atrophy. J Mol Neurosci. 2016 Mar;58(3):313-6. http://www.ncbi.nlm.nih.gov/pubmed/2687517393. Y. Ivashko-Pachima, L.Y. Zhou, P. Lei, I. Gozes. Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer's Disease. J Mol Neurosci. 2016 Feb;58(2):145-52. doi: 10.1007/s12031-016-0715-x.http://www.ncbi.nlm.nih.gov/pubmed/2681608294. Gozes I. The Future for Dementia Research: a Perspective from the Journal of Molecular Neuroscience. J Mol Neurosci. 2016 Nov;60(3):410-411. https://www.ncbi.nlm.nih.gov/pubmed/2764730695. Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR Jr, Miller BL, Rosen HJ, Boxer AL; AL-108-231 investigators (including Gozes I). Progression of brain atrophy in PSP and CBS over 6 months and 1 year. Neurology. 2016 Nov 8;87(19):2016- 2025.https://www.ncbi.nlm.nih.gov/pubmed/2774281496. Gozes I. PACAP, VIP, and ADNP: Autism and Schizophrenia. In: Pituitary Adenylate Cyclase Activating Polypeptide (Dora Reglodi and Andrea Tamas, Editors, Current Topics in Neurotoxicity 11, Springer) 2016 pp. 781-792.97. Gozes I. Sexual divergence in activity-dependent neuroprotective protein impacting autism, schizophrenia, and Alzheimer's disease. J Neurosci Res. 2017 Jan 2;95(1-2):652-660. https://www.ncbi.nlm.nih.gov/pubmed/2787044198. S. Sragovich, A. Merenlender-Wagner, and I. Gozes, ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease. BioEssays : news and reviews in molecular, cellular and developmental biology 39 (2017).99. I. Gozes, G. Hoglinger, J.P. Quinn, N.M. Hooper, and K. Hoglund, Tau Diagnostics and Clinical Studies. Journal of molecular neuroscience : MN 63 (2017) 123-130. https://www.ncbi.nlm.nih.gov/pubmed/29082468100. I. Gozes, Specific protein biomarker patterns for Alzheimer's disease: improved diagnostics in progress. EPMA J 8 (2017) 255 - 259. https://www.ncbi.nlm.nih.gov/pubmed/29021836https://www.ncbi.nlm.nih.gov/pubmed/28940660101. Gozes I, Ivashko-Pachima Y, Sayas CL. ADNP, a Microtubule Interacting Protein, Provides Neuroprotection Through End Binding Proteins and Tau: An Amplifier Effect. Front Mol Neurosci. 2018 May 1;11:151. doi: 10.3389/fnmol.2018.00151. eCollection 2018. https://www.frontiersin.org/articles/10.3389/fnmol.2018.00151/full102. Gozes I. Front. Neurosci., ADNP Regulates Cognition: A Multitasking Protein. 26 November 2018 | https://doi.org/10.3389/fnins.2018.00873 https://www.frontiersin.org/articles/10.3389/fnins.2018.00873/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Neuroscience&id=429007103. Dardiotis E, Aloizou AM, Markoula S, Siokas V, Tsarouhas K, Tzanakakis G, Libra M, Kyritsis AP, Brotis AG, Aschner M, Gozes I, Bogdanos DP, Spandidos DA, Mitsias PD, Tsatsakis A. Cancer-associated stroke: Pathophysiology, detection and management (Review) Int J Oncol. 2019 Mar;54(3):779-796. doi: 10.3892/ijo.2019.4669. Epub 2019 Jan 2. https://www.ncbi.nlm.nih.gov/pubmed/30628661104. Shioda S, Gozes I. Neuropeptides: From Bench to Bedside. Curr Pharm Des. 2018;24(33):3867. doi: 10.2174/138161282433190109122611. https://www.ncbi.nlm.nih.gov/pubmed/30693852
2016-2019 Ministry of Science and Technology, Israel, Eshkol Fellowships (Shlomo Sragovich, Gal Hacohen Kleiman, student fellowships)
2017-2020 NSF-BSF (US-Israel BiNational Science Foundation) - Computational Approaches to Assess Replicability of Neurobehavioral (~$32000, direct with three partners, including Prof. Yoav Benjamini and Professor Ilan Golani and Jackson Labs.)
2019-2020 Ministry of Defense Israel, Science Unit, Brain trauma biomarkers
2019-2022 ERA-NET Neuron, he pleiotropic effects of ADNP in Mental Disorders (Ministry of Health)
2008- A.M.N. Foundation
Donations: Drs. Ronith and Armand Stemmer, Mr Arthur Gerbi (French Friends of Tel Aviv University), and Spanish Friends of Tel Aviv University, Ms. Alicia Koplowitz