Prof. Ronit Eisenberg-Sagi

ביולוגיה תאית והתפתחותית סגל אקדמי בכיר
Prof. Ronit Eisenberg-Sagi
Phone: 03-6409500
Another phone: 03-6409320
Fax: 03-6407432
Office: Sackler School of Medicine, 312

Positions

Professor, Cell & Development Biology, Sackler Faculty of Medicine, Tel Aviv University

Chair, Scholarship Committee, Graduate School of Medicine

 

Biography

Education

1974 B.Sc. in Chemistry, with distinction Tel Aviv University
1980 Ph.D. in Biochemistry Tel Aviv University
1980-1984 Postdoctoral fellow The Weizmann Institute of Science

 

Research

Molecular Basis of Allergic Diseases: Genomic and Functional Analyses

Our primary interest is the molecular basis of allergic and allergy related diseases, including skin allergy and asthma. Specifically, we explore the mechanisms underlying release of allergic (i.e. histamine) and inflammatory (i.e. cytokines) mediators from activated mast cells. Our research focuses on deciphering the signaling networks that link mast cell activation with mediator release and characterization of genes that could serve as cellular targets for the future development of anti allergic and asthma drugs. To this end, we combine functional genomics and phenotype driven screens of mast cells, activated by multiple stimuli, in order to recapitulate human pathophysiologic conditions. Research methods used include confocal microscopy in live and fixed cells; gene cloning; quantitative RT-PCR, pull down-assay; mass spectrometry, and bioinformatics.

 

Current projects in the lab include:                                          

  • Exploring the genetic connections between the size of the mast cell secretory granules and mastocytosis.
  • Mast cells and cancer- the good, the bad and the ugly.
  • Decoding the Rab networks that control mast cell function.

 

Publications & Grants

Recent Publications

Efergan A, Azouz NP, Klein O, Noguchi K, Rothenberg ME, Fukuda M, Sagi-Eisenberg R. Rab12 regulates retrograde transport of mast cell secretory granules by interacting with the rilp-dynein complex. J Immunol. 2016;196:1091-101.

 

Azouz NP, Fukuda M, Rothenberg ME, Sagi- Eisenberg R. Investigating mast cell secretory granules; from biosynthesis to exocytosis. J Vis Exp. 2015;95:52505.

 

Rudich N, Dekel O, Sagi-Eisenberg R. Downregulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling. Mol Immunol. 2015;65:25-33.

 

Azouz, N.P., Zur, N., Efergan, Ohbayashi, N., Fukuda, M., Amihai, D., Hammel, I., Rothenberg, ME and Sagi-Eisenberg, R. Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo and exocytosis. J Immunol. 192:4043-53 (2014)

 

Bar-Gill-Benado, A., Efergan, A., Seger, R., Fukuda, M., and Sagi-Eisenberg R. The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells. Biochim Biophys Acta. 1833, 2070-2082, (2013).

 

Bernstein-Molho R., Kollender, Y., Issakov, J., Bickels, J., Dadia S., Flusser, G., Meller, I., Sagi-Eisenberg. R. and Merimsky O. Clinical activity of mTOR inhibition in combination with cyclophosphamide in the treatment of recurrent unresectable chondrosarcomas. Cancer Chemother Pharmacol. 70, 855-860, (2012).

 

Azouz NP, Matsui, T., Fukuda, M. and Sagi-Eisenberg, R. Decoding the regulation of mast cell exocytosis by networks of Rab GTPases. J Immunol. 189, 2169-2180. (2012).

 

Gorzalczany Y, Gilad Y, Amihai D, Hammel I, Sagi-Eisenberg R, and Merimsky O. Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: a beneficial strategy to combat non-small cell lung cancer. Cancer Lett. 310:207-215. (2011).

 

Baram D, Dekel O, Mekori YA, and Sagi-Eisenberg R. Activation of mast cells by trimeric G protein Gi3; coupling to the A3 adenosine receptor directly and upon T cell contact. J Immunol. 184:3677-3688. (2010).

 

 

Review

Rudich N, Ravid K, and Sagi-Eisenberg R. Mast cell adenosine receptors function: a focus on the A3 adenosine receptor and inflammation. Front Immunol. 3:134. (2012).

 

Siebenhaar F, Falcone FH, Tiligada E, Hammel I, Maurer M, Sagi-Eisenberg R, Levi-Schaffer F. The search for Mast Cell and Basophil models – Are we getting closer to pathophysiological relevance? Allergy 2015;70:1-5.

 

 

Grants

  • 2012-2015:  The Israel Science Foundation, Dissecting the molecular mechanisms underlying mast cell exocytosis; new insights provided by the small GTPase Rab5

Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel
Developed by
UI/UX Basch_Interactive