Prof. Bernard Attali

Emeritus in Physiology Pharmacology
Medicine Dean & Assoc. Deans
פיזיולוגיה ופרמקולוגיה אמריטוס
Phone: 03-6405116
Another phone: 03-6405571
Fax: 03-6409113
Office: Sackler School of Medicine, 546

Positions

Professor, Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University

 

Biography

Education

1989 Ph.D. Weizmann Institute of Science, Rehovot, Israel
1983 These de 3ieme cycle Paul Sabatier University, Toulouse, France
1980 D.E.A. at the CNRS  Paul Sabatier University, Toulouse, France
1979  B.S.in Pharmacy Paul Sabatier University, Toulouse, France
1976 M.Sc. in Physical Chemistry Paul Sabatier University, Toulouse, France

 

Research

Normal and Diseased Potassium Channels in Human Brain and Heart

Reaching an understanding in molecular terms of the mechanisms by which changes in membrane potential regulate cellular events is the main concern of our research. We focus our interest on potassium channels because they play crucial roles in many cellular functions such as shaping cardiac and neuronal action potentials, tuning neuronal firing patterns, synaptic integration or modulating neurotransmitter release. Using the powerful combination of molecular biology, biophysics, biochemistry and electrophysiology, our research aims at elucidating the structural, biophysical and physiological attributes of potassium channels in human brain and heart and whose mutations lead to major neurological and cardiovascular disorders like epilepsy, myokymia, atrial or ventricular fibrillation.

 

Publications

Manuscripts

Ebner-Bennatan S, Patrich E, Peretz A, Kornilov P, Tiran Z, Elson A, Attali B. (2012) Multi-faceted modulation of K+ channels by protein tyrosine phosphatase epsilon tunes neuronal excitability. J Biol Chem. 287:27614-27628.

 

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O, Attali B. (2013) SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells. Proc Natl Acad Sci USA. 110:E1685-94.

 

Kornilov P, Peretz A, Lee Y, Son K, Lee JH, Refaeli B, Roz N, Rehavi M, Choi S, Attali B. (2014) Promiscuous gating modifiers target the voltage sensor of Kv7.2, TRPV1, and Hv1 cation channels. FASEB J. 28:2591-602.

 

Gourgy-Hacohen O, Kornilov P, Pittel I, Peretz A, Attali B*, Paas Y* (2014). Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain. J Gen Physiol. 144:513-27.


Sachyani D, Dvir M, Strulovich R, Tria G, Tobelaim W, Peretz A, Pongs O, Svergun D, Attali B, Hirsch JA. (2014) Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. Structure. 22:1582-94.

 

Patrich E, Piontkewitz Y, Peretz A, Weiner I, Attali B. (2016). Maturation- and sex-sensitive depression of hippocampal excitatory transmission in a rat schizophrenia model. Brain Behav Immun. 51:240-51.


Patrich E, Piontkewitz Y, Peretz A, Weiner I, Attali B. (2016). Maternal immune activation produces neonatal excitability defects in offspring hippocampal neurons from pregnant rats treated with poly I:C. Sci Rep. 8;6:19106.

 

Reviews

Kornilov P, Peretz A, Attali B. (2013) Channel gating pore: a new therapeutic target. Cell Res. 23:1067-8.

 

Dvir M, Peretz A, Haitin Y, Attali B. (2014) Recent molecular insights from mutated IKS channels in cardiac arrhythmia. Curr Opin Pharmacol. 15:74-82.

 

Alexander SP, Kelly E, Marrion N, Peters JA, Benson HE….Attali, B..et CGTP Collaborators. (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172:5729-43. Attali B, Gao ZB. (2016). Ion channels research in the post-genomic era. Acta Pharmacol Sin. 37:1-3.

 

Weisbrod D, Khun SH, Bueno H, Peretz A, Attali B. (2016). Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels. Acta Pharmacol Sin. 37:82 -97.

 

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