Prof. Rina Arbesfeld

Clinical Microbiology and Immunology
מיקרוביולוגיה ואימונולוגיה קלינית סגל אקדמי בכיר
Prof. Rina Arbesfeld
Phone: 03-6408570
Another phone: 03-6406643
Fax: 03-6408287
Office: Sackler School of Medicine, 708

Positions

Full Professor, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine

Chair, Search Committee

 

Research

The Wnt Signaling Pathway and Colorectal Cancer

The Wnt signaling pathway is involved in virtually every aspect of human development, as well as in adult homeostasis. Hyperactivation of this pathway has been linked to a wide range of cancers and especially colorectal cancer. Our aim is to understand the molecular events underlying Wnt signal transduction, as well as develop novel therapeutic strategies to fight colorectal cancer.

 

Current projects in the lab include:

  1. Identifying and characterizing new Wnt signaling components.
  2. Developing new anti-colorectal cancer treatment strategies

 

Publications & Grants

Publications

Shalev M, Kandasamy J, Skalka N, Belakhov V, Rosin-Arbesfeld R, Baasov T. Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples. J Pharm Biomed Anal. 75:33-40, 2013

 

Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R. Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. Oncogene. 32:2836-47, 2013

 

Dovrat S, Caspi M, Zilberberg A, Lahav L, Firsow A, Gur H, Rosin-Arbesfeld R. 14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway. Mol Oncol. pii: S1574-7891(14)00059-3, 2014.

 

Naumov I, Zilberberg A, Shapira1 S, Avivi1 D, Kazanov1 D, Rosin-Arbesfeld R, Arber N, Kraus S. CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APCMin /CD24 double knockout transgenic mice. Int J Cancer. 2014 Feb 5. doi: 10.1002/ijc.28762.

 

Raviv S, Bharti K, Rencus-Lazar S, Cohen-Tayar Y, Schyr R, Evantal N, Meshorer E, Zilberberg A, Idelson M, Reubinoff B, Grebe R, Rosin-Arbesfeld R, Lauderdale J, Lutty G, Arnheiter H, Ashery-Padan R. (2014) PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet.10(5):e1004360.

 

Domke LM, Rickelt S, Dörflinger Y, Kuhn C, Winter-Simanowski S, Zimbelmann R, Rosin-Arbesfeld R, Heid H, Franke WW. (2014) The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures. Cell Tissue Res. 8(5):894-911.

 

Caspi M, Peri G, Skalka N, Meysel S, Firsow A Amit M, Rosin-Arbesfeld R. (2014) Aldolase positively regulates of the canonical Wnt signaling pathway. Molecr Cancer. 13(1):164.

 

Oz S, Kapitansky O, Ivashco-Pachima Y, Malishkevich A, Giladi E, Skalka N, Rosin-Arbesfeld R, Mittelman L, Segev O, Hirsch JA, Gozes I. (2014) The NAP-motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins. Mol Psych 19(10):1115-24.

 

Sominsky S, Kuslansky Y, Shapiro B, Jackman A, Haupt Y, Rosin-Arbesfeld R, Sherman L. (2014) HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling. Virology, 468-470:510-23. 28.

 

Franke WW, Zimbelmann R, Dörflinger , Kuhn C, Frey N, Heid H, Rosin-Arbesfeld R. (2015) Striatin family proteins, near-ubiquitous in mammalian cells, as constitutive components of the cytoplasmic plaques of the zonulae adhaerentes of simple epithelia, specific domains in the tessellate junctions of stratified epithelia and the myocardiac composite junctions. Cell Tissue Res 359(3):779-97.

 

Selvaraja P, Huanga JSW, Chena A, Skalka N, Rosin-Arbesfeld R, Loh YP. (2015) Neurotrophic factor-α1modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons. Mol. Cell. Neuro. 68:222-233.

 

Caspi M, Firsow A, Rajkumar R, Skalka N, Moshkovitz I, Munitz A, Pasmanik-Chor M, Greif H, Megido D, Kariv R, Rosenberg DW, Rosin-Arbesfeld R. (2016). A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation readthrough agents. J Mol Med (Berl). 94:469-482. 

 

Feldman M, Hershkovitz, Sklan EH, Kahila Bar-Gal G, Pap I, Szikossy I, Rosin-Arbesfeld R. (2016). Detection of a tumor suppressor gene variant predisposing to colorectal cancer in an 18th century Hungarian mummy. PLoS One. 11:e0147217.

 

Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K and Rosin-Arbesfeld R. (2016) Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. Oncogene. Jul 4. doi: 10.1038/onc.2016.173.

 

Yedid N, Kalma Y, Malcov M, Amit A, Kariv R; Caspi M Rosin-Arbesfeld R*, Ben-Yosef D (2016) The effect of a germline mutation in the APC gene on ß-catenin in human embryonic stem cells. BMC Cancer. *Equally corresponding authors.

 

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