Glutamate-regulatory Enzymes as an Emergency Neuroprotective Treatment

Faculty of Medical & Health Sciences, Sagol School of Neuroscience, Tel Aviv University, Israel

28 May 2024

Glutamate is the most widely distributed messenger substance of the central nervous system.

It is a decisive factor in nerve excitation, yet a high concentration can also cause nerve cells to die.

Angela Ruban’s idea entails lowering the concentration of glutamate following a nerve injury, reducing the toxic effect and resulting damage. Lower glutamate levels could even lead to improved recovery and regeneration. This approach has already been proven effective in experiments following a stroke or traumatic brain injury.

The administering of certain enzymes that break down glutamate resulted in improved motor function. This therapy could be clinically tested soon.

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