Revealing functional insights in cancer through proteogenomic research

The Departments of Clinical Microbiology and Immunology, Human Molecular Genetics and Biochemistry and Cell & Developmental Biology invite you to a special seminar 

By

Dr. Yifat Geffen

Cancer Genome Analysis- Broad Institute of MIT and Harvard, USA

 Title

Revealing functional insights in cancer through proteogenomic research

Abstract: 

Comprehensive genomic investigations have transformed our understanding of tumor biology and

significantly impacted patient care. However, the complex biology, molecular diversity, and

phenotypic variations in many cancers still pose challenges for effective treatments. To gain a

deeper understanding of the evolution, proliferation, and immune evasion mechanisms in different

cancer types, a more in-depth and comprehensive approach is needed.

Recent advancements in mass spectrometry enable large-scale quantification of protein levels and

post-translational modifications (PTMs) that can help bridge the gap in our understanding of the

phenotypic outcomes in cancer.

In this presentation, I will delve into how proteomic changes can unveil novel proteomic-centric

subtypes, prioritize driver mutations correlated with copy number alterations and protein

abundance, and demonstrate how PTMs contribute to the identification and characterization of

functional patterns across various cancer types, which may remain elusive at the genomic and

transcriptomic levels.

Finally, I will briefly discuss what I would like to see as the future of proteogenomics in cancer.

The seminar will take place on Wednesday, January 31, 2024 at 10:30

The Faculty of Medicine Building, Room 200