New research published by Prof. Gil Ast

Gene architecture directs splicing outcome in separate nuclear spatial regions

Tammer L, Hameiri O, Keydar I, Roy VR, Ashkenazy-Titelman A, Custódio N, Sason I, Shayevitch R, Rodríguez-Vaello V, Rino J, Lev Maor G, Leader Y, Khair D, Aiden EL, Elkon R, Irimia M, Sharan R, Shav-Tal Y, Carmo-Fonseca M, Ast G.

Published in Molecular Cell

• Differences in subnuclear regions determines alternative splicing
• Exon-intron GC content differs in these subnuclear regions
• Most compelling, this research creates a link between 3D genome organization and splicing

https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)00106-X