Ivo Spiegel-State-dependent modulation of sensory processing and plasticity in cortical circuits

05 May 2021, 13:00 
 
Ivo Spiegel-State-dependent modulation of sensory processing and plasticity in cortical circuits

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You are cordially invited to a seminar of the Dept. of Physiology and Pharmacology Sackler Faculty of Medicine

 

Ivo Spiegel

 

Weizmann Institute, Neurobiology

 

State-dependent modulation of sensory processing and plasticity in cortical circuits

 

The seminar will take place on Zoom

 

Wednesday, May 5, 2021 | 13:00

 

Here is the zoom link:

 

https://us02web.zoom.us/j/83358431895?pwd=MTVvZnNUUEMxMkxERXp4Z3YyMmcxZz09

 

 

Abstract: 

 

The brain’s ability to process and learn from sensory information is modulated by an animal’s behavioral state but the underlying cellular mechanisms are not well understood. In the cortex, layer 1 (L1) is a key site for integrating sensory-driven and behavioral state-dependent inputs from distal areas of the brain but it remains unclear how different types of neurons in L1 – most of them subtypes of GABAergic interneurons (INs) – control information processing and plasticity in lower cortical layers. In my talk I will discuss our recent experiments in which we analyzed the role of genetically-defined L1 INs in the state-dependent control over sensory processing in cortical circuits. I will discuss the results of these studies and propose an inhibition-/disinhibition-based cellular mechanism to explain how the state-dependent activation of L1 INs adapts the stimulus-evoked responses of principal excitatory neuron across all cortical layers to an animal's behavioral demands and how this may enable state-dependent learning.

 

 

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