Ariel Lonescu- The Interplay between Local Protein Synthesis and Axon/NMJ Maintenance and Degeneration in ALS

You are cordially invited to a seminar of the Dept. of Physiology and Pharmacology Sackler Faculty of Medicine

Ariel Lonescu

TAU, Perlson Lab

The Interplay between local protein synthesis and axon/NMJ maintenance and degeneration in ALS

The seminar will take place on Zoom

Wednesday, May 19, 2021 | 13:00

Here is the zoom link

https://us02web.zoom.us/j/88494416001?pwd=cnRuemd5NTVYbGlkNHJDODUrTVV5QT09

Abstract

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurological disease characterized by muscle atrophy and motor neuron death. In spite of some progress, there is currently no effective treatment available for ALS. However, before such a treatment can be developed, a more thorough understanding of ALS pathogenesis is required. One of the mechanisms suggested as an initiator of ALS pathology is an alteration in the process of local protein synthesis. In my seminar I will show that local synthesis is necessary for maintaining axons and neuromuscular junctions, and describe a novel mechanism that can regulate it