Deciphering ubiquitin-dependent cell-fate decisions during human development - one disease mutation at a time
You are cordially invited to a joint seminar of the Department of Cell & Developmental Biology, Sackler Faculty of Medicine and the BioMed@TAU Disorders of the Mind and Brain Research Hub
Achim Werner, Ph.D.
Stem Cell Biochemistry Unit
National Institute of Dental and Craniofacial Research (NIDCR)
Bethesda MD, USA
Deciphering ubiquitin-dependent cell-fate decisions during human development - one disease mutation at a time
Mammalian development relies on the precise execution of highly coordinated cell-fate decisions by stem cells, which can undergo self-renewal, reversibly exit into a quiescent state, or terminally commit to a cell differentiation program. To orchestrate these decisions, stem cells make frequent use of ubiquitylation, an essential post-translational modification that alters the stability, activity, localization, or interaction landscape of target proteins. My lab combines human genetics, pluripotent stem cell culture, proteomic, and biochemical approaches to determine the molecular underpinnings of ubiquitin-dependent cell-fate choices involved in neural crest and neuronal differentiation. I will present our latest findings on how variants in specific components of the ubiquitin conjugation and deconjugation machinery result in congenital disorders affecting central nervous system and craniofacial development and how we can leverage these mutations to uncover novel regulatory principles of early embryonic differentiation events.
April 26, 2022 02:30 PM
Join Zoom Meeting
https://tau-ac-il.zoom.us/j/85427785428
Meeting ID: 854 2778 5428
Hosts: Avraham Ashkenazi and Boaz Barak
