How GIN (GABAergic interneurons) & TONIC activity of cholinergic interneurons (CINs) affects striatal function
You are cordially invited to a seminar of the Department of Cell & Developmental Biology, Sackler Faculty of Medicine and the BioMed@TAU Disorders of the Mind and Brain Research Hub
Professor Joshua A. Goldberg
Department of Medical Neurobiology
Institute of Medical Research Israel-Canada
The Faculty of Medicine
The Hebrew University of Jerusalem
How GIN (GABAergic interneurons) & TONIC activity of cholinergic interneurons (CINs) affects striatal function
While the main function of the striatum is carried out by their two populations of spiny projection neurons (SPNs), there is a growing appreciation of how the striatal microcircuitry - that is composed of various classes of interneurons - modulates SPNs excitability and discharge.
In my talk I will describe two of our recent studies about how CINs impact striatal processing. In the first part, I will demonstrate that CINs can control the precise spike timing of SPNs via their tonic activation of nicotinic acetylcholine receptors on GINs. In the second part, I will propose that their dendritic nonlinearities (that we interrogate optogenetically) help them process their two excitatory afferent inputs differentially
Sunday April 3, 2022 @ 13:15
Room 927, Faculty of Medicine Building
Host: Avraham Ashkenazi, PhD
ashkenaziavi@tauex.tau.ac.il https://www.ashkenazilab.com
Refreshments will be served from 13:00
