Ayala Tovy: The multifaceted role of DNMT3A in human health and disease
You are cordially invited to a special seminar of the Department of Human molecular Genetics and Biochemistry Sackler Faculty of Medicine
By: Ayala Tovy, Ph.D.
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Texas, USA
Title: The mutlifaceted role of DNMT3A in human health and disease
Abstract:
The DNA methyltransferase DNMT3A is mostly known as the blood system tumor suppressor, since somatic mutations in DNMT3A are frequently found in hematological malignancies. However, heterozygous germline DNMT3A mutations lead to Tatton-Brown-Rahman Syndrome (TBRS), a disorder characterized by overgrowth, developmental delay, and obesity. How DNMT3A drives its tumor suppressor role in the blood compartment, and whether this role is linked to its role in TBRS is unknown. My talk will address those questions and describe how a rare disease can be used as a model to address questions relevant to us all.
The Seminar will take place on Thursday, December 10th, 2020 at 16:00
Zoom link:
https://us02web.zoom.us/j/85044513682
Meeting ID: 850 4451 3682
