Dror Chorev, Ph.D.: The importance of being in the membrane

You are cordially invited to a special seminar of the Department of Human molecular Genetics and Biochemistry Sackler Faculty of Medicine

By: Dror Chorev, Ph.D.

"The importance of being in the membrane"

Abstract:

Within cell membranes are numerous proteins and protein complexes that are responsible for the execution of a multitude of functions essential to maintain life. To study these membrane proteins, they are typically extracted and removed from their native lipid environment by detergents and polymers. In this talk, I will present a recent break-through, in which we have been able to eject and analyse membrane proteins and their associated small molecules directly from vesicles derived from their membrane of origin, inside a mass spectrometer, with no recourse to any chemical additives. From bacterial membrane protein insertases to respiratory complexes and G-protein coupled receptors, this approach has revealed new insights into the structure and function of membrane proteins, emphasizing the importance of the native membrane to the proteins that reside within it.

The Seminar will take place on

Monday, November 15th, 2021 at 13:15 PM,

At Sackler Faculty of Medicine Building, Room 100