Dr. Daniel Bar
Molecular Biology of Aging
Advances in biomedical science have cured multiple diseases and greatly improved healthspan and lifespan. However, aging is the strongest risk factor for most causes of death in the western world, and thus these advances have resulted in a relatively small increase in maximal lifespan. Without a systematic approach to understand and treat the aging process, it is unlikely that the phenomenal improvement in healthspan and lifespan seen over the last 100 years will continue. In light of these views, we aim to contribute to the understanding of the aging process and its modulation.
In our lab, we aim to develop new methods and use them to answer questions related to aging. Recently, members of the lab have developed a novel approach to determine the local protein environment near targets of interest in human samples. We are using this method to explore the composition of the nuclear envelope directly from different human tissues. This method can accurately quantify nuclear envelope composition, and monitor how that changes with age in mouse and human tissues. Our lab is using this unique method to comprehensively explore how the proteome of specific subcellular structures changes with age. In parallel, we use proximity-labeling method to unravel disease mechanisms. Another ongoing project in our lab is the development of an alternative method to ChIP-seq for mapping DNA protein binding sites. We are already able to detect protein binding event on long single molecules and now developing and implementing this method, leveraging it to answer open questions about the biology of aging."