Cleared Tissue LightSheet (CTLS)

The Cleared Tissue LightSheet (CTLS) microscope is an advanced imaging system designed for whole organ imaging. It utilizes dual-side illumination and incorporates a fully automated macro zoom microscope with high numerical aperture (NA) objectives (1.0x/0.25NA, 1.5x/0.37NA, and 2.3x/0.57NA), a spatial light modulator (SLM), and a back-thinned sCMOS camera to optimize the lightsheet for high-resolution imaging. The system also features an Infinity Beam technology, reducing shadows caused by opaque structures in the specimen. With the use of a back-thinned sCMOS camera, CTLS can image entire organs at high-resolution with low photobleaching, allowing for imaging of one cubic centimeter volumes in less than an hour. Additionally, there is a CTLS-XL version with a larger chamber, ideal for imaging entire mice or large organs up to 20mm in width and 60mm in length. The XL version uses a 0.5x imaging objective with a 114mm working distance for fast imaging of large samples. CTLS and CTLS-XL represent cutting-edge tools for cleared tissue imaging of whole animals, large organs, and smaller specimens.

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