Full Grants

Identification of Novel Genetic Risk Factors of Parkinson' Disease and of Disease Risk in GBA1 Carriers using Data-Intensive Genomic Analyses

• Prof. Ran Elkon | Department of Human Molecular Genetics and Biochemstry, Gray Faculty of Medical and Health Sciences
   
• Prof. Roy Alcalay | Sagol School of Neuroscience, Tel Aviv University; Laboratory of Biomarkers and Genomics of Neurodegeneration, Tel Aviv Sourasky Medical Center 
   
• Dr. Orly Goldstein | Laboratory of Biomarkers and Genomics of Neurodegeneration, Tel Aviv Sourasky Medical Center

In this study, we aim to leverage on cutting-edge and GBA1-PD (Tel Aviv Medical center) and large databases in the PD research community (AMP-PD, GP-2) to further expand our understanding of PD genetics. Explore >>

Engineering EVs for Efficient Loading and Targeted Delivery of Antibodies Against Alpha-Synuclein

• Prof. Daniel Offen | Dept. Human Molecular Genetics and Biochemistry, Gray Faculty of Medical and Health Sciences, Tel Aviv University; Rabin Medical Center

This project aims to develop a novel Multiple System Atrophy (MSA) treatment using MSC-derived extracellular vesicles to deliver antibodies against alpha-synuclein, neutralizing pathogenic aggregates. Explore >>

Identification of Candidate Imaging Markers for Parkinson's Disease in Heathy "At Risk" Subjects that Converted to Disease: A Retrospective Analysis

• Prof. Avner Thaler | Sagol School of Neuroscience, Gray Faculty of Medical and Health Sciences; Laboratory for Early Markers of Neurodegeneration (LEMON), Tel Aviv Sourasky Medical Center
   
• Dr. Amgad Droby | Sagol Shool of Neuroscience

Over the past ten years, we followed up 70 participants and found that 10 developed clinical PD. We now aim to follow up with the remaining 30 participants and retrospectively analyze their scans to identify potential imaging markers associated with PD. Explore >>

Understanding the Progression of Sleep Related Disorders in the Prodromal Phase of Parkinson's Disease (PD)

• Prof. Anat Mirelman | Sagol School of Neuroscience, Gray Faculty of Medical and Health Sciences; Laboratory for Early Markers of Neurodegeneration (LEMON), Tel Aviv Sourasky Medical Center
   
• Prof. Yael Hanein |  School of Electrical Engineering, Faculty of Engineering

We aim to identify sleep metrics that can predict PD progression. Our goal is to improve early detection and personalized care for PD, by providing sensitive validated measures that reflect a major aspect of daily living.

This study combines the expertise of Prof. Anat Mirelman, an expert in neurodegeneration, and technology developer Prof. Yael Hanein to advance research and treatment in Parkinson's Disease. Explore >>

The Pathogenic Mechanisms of GBA1-Associated Parkinson's and their Mitigation by Small Molecule Inhibitors

• Prof. Miguel Weil | George S. Wise Faculty of Life Sciences, Department of Cell Research and Immunology
   
• Prof. Daniel Segal | Emeritus,  George S. Wise Faculty of Life Sciences, Department Molecular Microbiology and Biotechnology; Tel Aviv University

In the present proposal we aim at identifying the cellular processes that go awry in GBA1-associated PD, and examine how the small molecules ameliorate them. Explore >>