Understanding the Progression of Sleep Related Disorders in the Prodromal Phase of Parkinson's Disease (PD)

Sleep disorders, especially REM sleep behavior disorder (RBD), are common in Parkinson's Disease (PD) and often signal neurodegeneration years before other symptoms appear.

This study aims to track changes in sleep patterns over time in people with early-stage PD and those at risk.

Using a wearable sleep monitoring system, we will monitor 120 participants, including healthy individuals, those at risk for PD, people with RBD, and early-stage PD patients.

Follow-up assessment will occur within three years from baseline to track sleep changes and their link to disease progression. By analyzing their sleep data, we aim to identify sleep metrics that can predict PD progression.

Our goal is to improve early detection and personalized care for PD, by providing sensitive validated measures that reflect a major aspect of daily living.

This study combines the expertise of Prof. Anat Mirelman, an expert in neurodegeneration, and technology developer Prof. Yael Hanein to advance research and treatment in Parkinson's Disease.