Identification of Candidate Imaging Markers for Parkinson's Disease in Heathy "At Risk" Subjects that Converted to Disease: A Retrospective Analysis

Parkinson's disease (PD) is a neurodegenerative condition with a long prodromal period and genetic risk factors. Currently, it is difficult to predict who will develop PD and when.

Mutations in the LRRK2 and GBA1 genes are significant risk factors, but most carriers do not develop the disease. Structural and functional MRI scans are non-invasive and radiation-free, making them useful for monitoring at-risk individuals.

Previously, we collected MRI data from 100 individuals with LRRK2 and GBA1 mutations. Over the past ten years, we followed up 70 participants and found that 10 developed clinical PD.

We now aim to follow up with the remaining 30 participants and retrospectively analyze their scans to identify potential imaging markers associated with PD.