Prof. Eran Perlson

Prof. Eran Perlson is an Associate Professor with the long-term research goal to understand the molecular mechanisms of neurodegeneration during diseases like ALS. His scientific work has earned him many distinguished grants, awards, and honors, and he is the author of numerous high-profile scientific publications and invited speaker to lead international meetings.

Neuron cell death and synapse disruption occur during aging and neurodegenerative diseases like Amyotrophic Lateral Sclerosis )ALS(. The goal of the Perlson lab is to elucidate the molecular mechanisms of motor neuron degeneration in ALS. The lab study mechanisms of axon and neuromuscular junction degeneration and regeneration. The Perlson lab combines advanced microscopy, transgenic mice models, human iPSC, and a unique Lab-on-a-Chip platform that mimics the motor unit. This platform enables the growth of neurons and muscle on a silicon chip and provides a powerful tool for studying new neuromuscular junction biology in health and disease.

Current efforts are focused on • Local protein synthesis in axons and NMJs • Mitochondrial maintenance at the NMJs • Phase separation at axon/NMJ • Neurotropic signaling